发明申请
- 专利标题： DOWNREGULATION OF CIRCULATING GHRELIN AND THERAPEUTIC APPLICATIONS THEREOF
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申请号： PCT/US2022/075391申请日： 2022-08-24
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公开(公告)号： WO2023028518A2公开(公告)日： 2023-03-02
- 发明人: ZHAN, Chang-Guo , ZHENG, Fang
- 申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 申请人地址： 201 Gillis Building
- 专利权人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人地址： 201 Gillis Building
- 代理机构： DECKER, Mandy Wilson et al.
- 优先权： US63/236,532 2021-08-24
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61P3/04 ; A61P25/30 ; C12N9/18 ; A61K38/48
摘要：
Compositions and methods for converting ghrelin to desacyl-ghrelin include a butyrylcholinesterase (BChE) polypeptide variant. The presently-disclosed subject matter includes compositions and methods for use in directly downregulating ghrelin. In particular, certain embodiments relate to compositions and methods for hydrolyzing/deacylating ghrelin to desacyl-ghrelin and applications thereof in the treatment of disorders involving ghrelin.
IPC分类:
