公开(公告)号：WO2018026810A1

公开(公告)日：2018-02-08

申请号：PCT/US2017/044893

申请日：2017-08-01

Applicant: VANDERBILT UNIVERSITY

Inventor： KANG, Jing-Qiong

IPC: C07D487/22

Abstract: Treatment of conditions with celastrol are disclosed herein. In particular, methods of administration of celastrol for the treatment of neurological and non-neurological disorders, including epilepsy are provided.

Abstract translation: 本文公开了用雷公藤红素处理条件。 具体而言，提供了用于治疗神经性和非神经性病症（包括癫痫症）的雷公藤红素的施用方法。

公开(公告)号：WO2014168950A1

公开(公告)日：2014-10-16

申请号：PCT/US2014/033337

申请日：2014-04-08

Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： LAWRENCE, David L. ,  SHELL, Thomas

IPC: A61K31/714 ,  A61K39/395 ,  A61K48/00

CPC classification number: A61K41/0042 ,  A61K31/165 ,  A61K31/519 ,  A61K31/573 ,  A61K31/69 ,  A61K31/7076 ,  A61K35/18 ,  A61K47/48092 ,  A61K47/549 ,  A61K2035/124 ,  C07F15/065

Abstract: The presently-disclosed subject matter provides photo-responsive compounds and methods of use thereof. The photo-responsive compounds comprise a photolabile molecule and a fluorophore appended to the photolabile molecule. The presently- disclosed subject matter further relates to a drug delivery system that uses red blood cells to deliver photo-responsive compounds for the treatment of disease.

Abstract translation: 目前公开的主题提供光敏化合物及其使用方法。 光敏化合物包括光不稳定分子和附着于光不稳定分子的荧光团。 目前公开的主题还涉及使用红细胞递送用于治疗疾病的光敏化合物的药物递送系统。

公开(公告)号：WO2014164805A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/023525

申请日：2014-03-11

Applicant: UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： RUBENSTEIN, David ,  RUNAGER, Kasper

IPC: C12N15/113 ,  A61K48/00

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y204/01186 ,  C12Y204/01255

Abstract: The presently disclosed subject matter provides compounds, compositions, and methods for targeting UDP-N-acetylglucosamine polypeptide β-N-acetylglucosaminyl transferase (OGT). Further, the presently disclosed subject matter provides compounds, compositions, and methods for promoting wound healing.

Abstract translation: 目前公开的主题提供了用于靶向UDP-N-乙酰葡糖胺多肽＆bgr-N-乙酰葡糖胺基转移酶（OGT）的化合物，组合物和方法。 此外，本发明公开的主题提供了用于促进伤口愈合的化合物，组合物和方法。

公开(公告)号：WO2014160336A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/026340

申请日：2014-03-13

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： AMBATI, Jayakrishna

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00

CPC classification number: C07K16/2893 ,  A61K39/3955 ,  A61K39/39566 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/06 ,  C07K16/1027 ,  C07K16/22 ,  C07K16/241 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/76

Abstract: A method of suppressing angiogenesis involves administering to a subject an isolated Fc fragment of an IgG1 antibody, or an IgG1 antibody.

Abstract translation: 抑制血管发生的方法包括向受试者施用IgG1抗体或IgG1抗体的分离的Fc片段。

公开(公告)号：WO2013063439A1

公开(公告)日：2013-05-02

申请号：PCT/US2012/062181

申请日：2012-10-26

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： HAO, Hongying ,  MCMASTERS, Kelly M. ,  XIAO, Deyi

IPC: C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6886 ,  C12N2310/141 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The presently disclosed subject matter provides methods of characterizing a melanoma in a subject by measuring amounts of one or more RNAs, miRNAs, and/or polypeptides present in cancer-derived microvesicles isolated from a biological sample from the subject.

Abstract translation: 目前公开的主题提供了通过测量从受试者的生物样品分离的癌衍生的微泡中存在的一种或多种RNA，miRNA和/或多肽的量来表征受试者中的黑素瘤的方法。

公开(公告)号：WO2013043719A1

公开(公告)日：2013-03-28

申请号：PCT/US2012/056110

申请日：2012-09-19

Applicant: VANDERBILT UNIVERSITY

Inventor： DAVIES, Sean S. ,  CHEN, Zhongyi ,  GUO, Lilu ,  ZHANG, Yongqin

IPC: A61K31/16 ,  A61K31/164 ,  A61K31/685 ,  A61K9/133 ,  A61K9/20 ,  A61P3/04 ,  A61P3/00

CPC classification number: A61K35/74 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/496 ,  A61K31/7036 ,  A61K31/7048 ,  A61K35/744 ,  A61K35/745 ,  A61K36/064 ,  A61K38/14 ,  A61K38/45 ,  A61K38/465 ,  A61K45/06 ,  Y02A50/473 ,  A61K2300/00

Abstract: A method for treating obesity, insulin sensitivity, and related conditions involves administering to the subject a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE). A composition includes a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE); and an ingestible vehicle in which the bacterium is provided.

Abstract translation: 治疗肥胖症，胰岛素敏感性和相关病症的方法涉及向受试者施用过表达N-酰基 - 磷脂酰乙醇胺（NAPE）和/或N-酰基乙醇胺（NAE）的细菌。 组合物包括用于过表达N-酰基 - 磷脂酰乙醇胺（NAPE）和/或N-酰基乙醇胺（NAE）的细菌; 和其中提供细菌的可摄取的载体。

公开(公告)号：WO2023043821A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/043503

申请日：2022-09-14

Applicant: HOWARD HUGHES MEDICAL INSTITUTE

Inventor： STERN, David, L. ,  HAN, Clair

IPC: C07K14/435 ,  C12N5/04 ,  C12N15/64 ,  C12N15/82

Abstract: A method of identifying a bicycle gene involves determining for a candidate gene a series of gene structure-based predictor variables, and applying a bicycle gene classifier including the predictor variables to determine whether the candidate gene is identified as a bicycle gene. The gene structure-based predictor variables can be selected from the following: (i) total gene length (base pair, bp); (ii) total length (bp) of coding exons; (iii) first coding exon length (bp); (iv) last coding exon length (bp); (v) number of internal exons in phase 0; (vi) number of internal exons in phase 1; (vii) number of internal exons in phase 2; and (viii) mean internal exon length (bp).

公开(公告)号：WO2022187648A1

公开(公告)日：2022-09-09

申请号：PCT/US2022/018941

申请日：2022-03-04

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： MERTENS, Randall Tyler ,  AWUAH, Samuel Gorman

IPC: C07F1/00 ,  C07F9/54 ,  A61K31/28 ,  A61N5/10 ,  A61P35/00

Abstract: The presently-disclosed subject matter tri-coordinate Au(I) complexes, and methods of using tri-coordinate Au(I) complexes for selectively disrupting mitochondrial structure of target cancer cells.

公开(公告)号：WO2021146327A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/013293

申请日：2021-01-13

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： GORDON, Scott

IPC: A61P1/16 ,  C07K14/47 ,  C12N15/113

Abstract: Methods of treating hepatic steatosis involve administering to a subject a DENND5B inhibitor, thereby reducing the expression of and/or activity of DENND5B in liver of the subject. The DENND5B inhibitor can include antisense oligonucleotide (ASO), CRISPR interference (CRISPRi), miRNA, siRNA, locked nucleic acid (LNA) nucleotides, or a combination thereof.

公开(公告)号：WO2021102279A1

公开(公告)日：2021-05-27

申请号：PCT/US2020/061537

申请日：2020-11-20

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： YANG, Chengfeng ,  WANG, Zhishan ,  LI, Yunfei

IPC: A61K49/04 ,  A61L24/00 ,  A61L24/06

Abstract: Treatments for cancer include miriplatin assembled into an ultrasmall dot (uPtD) and/or lomitapide or a pharmaceutically-acceptable salt thereof. The uPtD and/or lomitapide can be encapsulated in a nanoparticle for administration to a subject. Some embodiments further include paclitaxel or a pharmaceutically-acceptable salt thereof.