Technologies for identifying genetic engineering proteins, organisms, and context signatures include a computing device that may be in communication with multiple client devices. The technologies include receiving a query sequence for a biological specimen, determining an alignment of the query sequence for regions of interest, and determining whether a match exists upstream or downstream from the region of interest in a predetermined database of genetic engineering context signatures. The search range may be predetermined based on each context signature. The technologies further include determining an alignment of the query sequence against a predetermined database of sequences indicative of genetic engineering, and determining whether a similarity score of the alignment exceeds a predetermined threshold. The database may include a genetic engineering protein database or a genetic engineering organism database. Other embodiments are described and claimed.