公开(公告)号：WO2013067281A1

公开(公告)日：2013-05-10

申请号：PCT/US2012/063205

申请日：2012-11-02

Applicant: BATTELLE MEMORIAL INSTITUTE ,  PETREL, Trevor ,  BARTLING, Craig ,  FURCI, Lena M. ,  HOWLAND, Carrie

Inventor： PETREL, Trevor ,  BARTLING, Craig ,  FURCI, Lena M. ,  HOWLAND, Carrie

IPC: A61K9/14

CPC classification number: A61K9/16 ,  A61K9/1682 ,  A61K9/1688 ,  A61K38/443 ,  B01F3/0853 ,  B01F3/0861 ,  B01F5/0057 ,  B01F5/0606 ,  B01F13/08 ,  B01F2215/0032 ,  B01J2/06 ,  C07K1/1136 ,  C12Y101/03004

Abstract: Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.

Abstract translation: 公开了在环境条件下生产生物活性，富含蛋白质的微粒的方法和装置。 将蛋白质溶液雾化并收集在正在混合的脱水溶剂中。 所得蛋白质微粒保留高比活性，而不需要大量的稳定赋形剂。

公开(公告)号：WO2023069985A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/078354

申请日：2022-10-19

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： TABBAA, Omar P. ,  BARTLING, Craig M. ,  FOWLE, Brett R. ,  FULLERTON, Patrick ,  GEMLER, Bryan ,  HOWLAND, Carrie ,  HUK, Danielle J. ,  SHANK, Zachary R.

IPC: G16B30/10 ,  G16B50/30 ,  G16B99/00

Abstract: Technologies for identifying genetic engineering proteins, organisms, and context signatures include a computing device that may be in communication with multiple client devices. The technologies include receiving a query sequence for a biological specimen, determining an alignment of the query sequence for regions of interest, and determining whether a match exists upstream or downstream from the region of interest in a predetermined database of genetic engineering context signatures. The search range may be predetermined based on each context signature. The technologies further include determining an alignment of the query sequence against a predetermined database of sequences indicative of genetic engineering, and determining whether a similarity score of the alignment exceeds a predetermined threshold. The database may include a genetic engineering protein database or a genetic engineering organism database. Other embodiments are described and claimed.