- 专利标题： BENZO[H]QUINAZOLINE-4-AMINE DERIVATIVES FOR THE TREATMENT OF CANCER
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申请号： PCT/EP2022/079738申请日： 2022-10-25
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公开(公告)号： WO2023072913A1公开(公告)日： 2023-05-04
- 发明人: WEILER, Sven , GAUCHER, Bérangère , RICHALET, Florian , RADIMERSKI, Thomas , ALOIA, Andrea
- 申请人： TWENTYEIGHT-SEVEN, INC.
- 申请人地址： 490 Arsenal Way
- 专利权人： TWENTYEIGHT-SEVEN, INC.
- 当前专利权人： TWENTYEIGHT-SEVEN, INC.
- 当前专利权人地址： 490 Arsenal Way
- 优先权： EP21204520.7 2021-10-25
- 主分类号： C07D239/70
- IPC分类号： C07D239/70 ; C07D401/04 ; C07D403/04 ; C07D405/12 ; C07D498/02 ; A61K31/506 ; A61K31/537 ; A61K31/5377 ; A61K31/538 ; A61P35/00
摘要：
The invention provides compounds of formula (I) (I)and pharmaceutically acceptable salts thereof; whereinRa and Rb are both -CH3 or Ra and Rb together form a -CH2-CH2-CH2- or a -CH2-CH2-CH2-CH2-bridging moiety;A is -CH2- or -C(=O)-;T is -N(R11)-, -N(R11)-C(=O)-, -N(R11)-S(O2)-, -O-, -C(R12)(R13)-, -C=C(R12)2, -S-, -S(O)-, -S(O2)-, -S(O2)-N(R14)- or -C(=O)-N(R14)-;and wherein R1, R2, R11, R12, R13 and R14 are as defined in the claims, as well as methods of using the compounds for the treatment of neoplastic diseases such as cancer.
