公开(公告)号：WO2023039089A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/042937

申请日：2022-09-08

申请人： TWENTYEIGHT-SEVEN, INC.

发明人： HARVEY, Darren, Martin ,  GHOSH, Shomir

IPC分类号： C07D401/04 ,  C07D471/04 ,  C07D519/00 ,  A61P5/00 ,  A61P7/00 ,  A61P9/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P27/00 ,  A61P31/20 ,  A61P35/00 ,  A61P37/04 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/519

摘要： The invention relates to a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same.

公开(公告)号：WO2023072913A1

公开(公告)日：2023-05-04

申请号：PCT/EP2022/079738

申请日：2022-10-25

申请人： TWENTYEIGHT-SEVEN, INC.

发明人： WEILER, Sven ,  GAUCHER, Bérangère ,  RICHALET, Florian ,  RADIMERSKI, Thomas ,  ALOIA, Andrea

IPC分类号： C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D498/02 ,  A61K31/506 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/538 ,  A61P35/00

摘要： The invention provides compounds of formula (I) (I)and pharmaceutically acceptable salts thereof; whereinRa and Rb are both -CH3 or Ra and Rb together form a -CH2-CH2-CH2- or a -CH2-CH2-CH2-CH2-bridging moiety;A is -CH2- or -C(=O)-;T is -N(R11)-, -N(R11)-C(=O)-, -N(R11)-S(O2)-, -O-, -C(R12)(R13)-, -C=C(R12)2, -S-, -S(O)-, -S(O2)-, -S(O2)-N(R14)- or -C(=O)-N(R14)-;and wherein R1, R2, R11, R12, R13 and R14 are as defined in the claims, as well as methods of using the compounds for the treatment of neoplastic diseases such as cancer.

公开(公告)号：WO2021178420A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/020494

申请日：2021-03-02

申请人： TWENTYEIGHT-SEVEN, INC.

发明人： ERICSSON, Anna M. ,  GHOSH, Shomir ,  HARVEY, Darren Martin

IPC分类号： C07D403/04 ,  C07D403/14 ,  A61K31/4375 ,  A61K31/4709 ,  A61P35/00

摘要： The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.