公开(公告)号：EP2238079A2

公开(公告)日：2010-10-13

申请号：EP08866242.4

申请日：2008-12-19

申请人： Aethlon Medical, Inc.

发明人： TULLIS, Richard ,  HANDLEY, Harold, H. ,  DUFFIN, Paul

IPC分类号： C02F1/44 ,  A61K39/42

CPC分类号： A61M1/3486

摘要： An extracorporeal fluid treatment apparatus includes a separator comprising a cartridge surrounding a porous separation membrane. The membrane separates a main flow path of a cellular component of the blood from a plasma flow path. An affinity medium is disposed within the plasma flow path to bind contaminants such as viral pathogens or toxins contained within the plasma. A pump pumps the plasma through the affinity medium at an assisted flow rate preferably between 10% and 40% of the whole blood flow rate. The assisted flow rate is selected to reduce a T90% of the apparatus by at least 50% as compared to a T90% of the apparatus without the plasma pump. A method of treating blood containing contaminants includes supplying infected blood to a separator and pumping the plasma component through an affinity medium at an assisted flow rate to increase contaminant clearance.

公开(公告)号：EP4416508A1

公开(公告)日：2024-08-21

申请号：EP22881946.2

申请日：2022-10-10

申请人： Aethlon Medical, Inc.

发明人： FISHER, JR., Charles J. ,  CAMPION, Rosalia De Necochea ,  LAROSA, Steven P. ,  MARLEAU, Annette ,  JACOBS, Michael

IPC分类号： G01N33/543 ,  B01D15/38 ,  B01D61/02 ,  G01N33/569 ,  A61M1/34 ,  A61M1/36 ,  G01N33/53 ,  G01N33/566

CPC分类号： A61M1/3679 ,  A61M1/3486 ,  A61M2202/20620130101 ,  B01D63/02 ,  B01D61/145 ,  B01D15/3823 ,  G01N33/56983 ,  G01N2333/16520130101 ,  G01N2333/0520130101 ,  G01N2800/5220130101

公开(公告)号：EP3517151A1

公开(公告)日：2019-07-31

申请号：EP19161598.8

申请日：2007-03-09

申请人： Aethlon Medical, Inc.

发明人： ICHIM, Thomas ,  TULLIS, Richard H.

IPC分类号： A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  B01D15/00

摘要： The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.

公开(公告)号：EP1624785A2

公开(公告)日：2006-02-15

申请号：EP04703672.8

申请日：2004-01-20

申请人： Aethlon Medical, Inc.

发明人： TULLIS, Richard, H.

IPC分类号： A61B1/00

CPC分类号： A61M1/3486 ,  A61L2/02 ,  A61L2/022 ,  A61M1/3472

摘要： The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.

公开(公告)号：EP3517151B1

公开(公告)日：2021-04-21

申请号：EP19161598.8

申请日：2007-03-09

发明人： ICHIM, Thomas ,  TULLIS, Richard H.

IPC分类号： A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  B01D15/00

公开(公告)号：EP2318031A2

公开(公告)日：2011-05-11

申请号：EP09759338.8

申请日：2009-06-03

申请人： Aethlon Medical Inc

发明人： TULLIS, Richard, H. ,  HANDLEY, Harold, H., Jr. ,  DUFFIN, R., Paul ,  JOYCE, James, A.

IPC分类号： A61K38/16 ,  A61P31/12 ,  A61P31/18 ,  A61K38/21

CPC分类号： A61K38/21 ,  A61K38/13 ,  A61M1/3472 ,  A61M1/3479 ,  A61M2202/206 ,  Y02A50/385 ,  Y02A50/393

摘要： Embodiments of the present invention relate to enhanced antiviral therapy methods, devices, and kits for treating viral infections. The disclosed enhanced antiviral therapy methods, devices, and kits enhance the efficacy of an antiviral therapy by administering a lectin affinity hemodialysis treatment to an individual suffering from viral infection in combination with the antiviral therapy.

公开(公告)号：EP1624785A4

公开(公告)日：2007-10-17

申请号：EP04703672

申请日：2004-01-20

申请人： AETHLON MEDICAL INC

发明人： TULLIS RICHARD H

IPC分类号： A61L2/02 ,  A61B20060101 ,  A61B1/00 ,  A61M1/14 ,  A61M1/34 ,  A61M1/38 ,  A61M37/00

CPC分类号： A61M1/3486 ,  A61L2/02 ,  A61L2/022 ,  A61M1/3472

摘要： The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.

公开(公告)号：EP1993600A4

公开(公告)日：2014-02-19

申请号：EP07752778

申请日：2007-03-09

申请人： AETHLON MEDICAL INC

发明人： ICHIM THOMAS ,  TULLIS RICHARD H

IPC分类号： A61M1/36 ,  B01D15/00 ,  B01J20/28 ,  B01J20/32

CPC分类号： A61M1/362 ,  A61M1/16 ,  A61M1/3496 ,  A61M1/3679 ,  B01D15/00 ,  B01J20/28014 ,  B01J20/3242

摘要： The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.

公开(公告)号：EP2318031A4

公开(公告)日：2012-09-12

申请号：EP09759338

申请日：2009-06-03

申请人： AETHLON MEDICAL INC

发明人： TULLIS RICHARD H ,  HANDLEY HAROLD H JR ,  DUFFIN R PAUL ,  JOYCE JAMES A

IPC分类号： A61K38/16 ,  A61K38/13 ,  A61K38/21 ,  A61M1/34 ,  A61P31/12 ,  A61P31/18

CPC分类号： A61K38/21 ,  A61K38/13 ,  A61M1/3472 ,  A61M1/3479 ,  A61M2202/206

摘要： Embodiments of the present invention relate to enhanced antiviral therapy methods, devices, and kits for treating viral infections. The disclosed enhanced antiviral therapy methods, devices, and kits enhance the efficacy of an antiviral therapy by administering a lectin affinity hemodialysis treatment to an individual suffering from viral infection in combination with the antiviral therapy.

公开(公告)号：EP2344233A1

公开(公告)日：2011-07-20

申请号：EP09815068.3

申请日：2009-09-15

申请人： Aethlon Medical, Inc.

发明人： TULLIS, Richard, H. ,  HANDLEY, Harold, H. ,  JOYCE, James, A. ,  DUFFIN, Paul

IPC分类号： A61M37/00 ,  A61K39/29

CPC分类号： C12N7/00 ,  A61M1/3679 ,  A61M2202/206 ,  C12N2770/24251

摘要： The present technology relates to methods and systems for the removal of pathogens and fragments thereof in hemodialysis patients. In particular, methods and systems are described where lectins can be used to remove the Hepatitis C virus and fragments thereof in hemodialysis patients, and to provide a sustained reduction in viral load.