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    POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS
    4.
    发明公开
    POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS 审中-公开
    带双抗凝血酶III结合位点，它们的生产和它们作为抗血栓多糖

    公开(公告)号：EP2697265A1

    公开(公告)日：2014-02-19

    申请号：EP12718395.2

    申请日：2012-04-11

    申请人： SANOFI

    发明人： MOURIER, Pierre ,  VISKOV, Christian

    IPC分类号： C08B37/00 ,  A61K31/727

    CPC分类号： A61K31/727 ,  A61K45/06 ,  B01D15/1878 ,  B01D15/34 ,  B01D15/363 ,  B01D15/3823 ,  C08B37/0075 ,  Y10T436/143333

    摘要： The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I) in which: R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide; R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond. Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analyzing a sample of a heparin derivative.