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    AMORPHOUS PICEATANNOL 3'-O-GLUCOSIDE AND PREPARATION METHOD THEREOF
    5.
    发明公开
    AMORPHOUS PICEATANNOL 3'-O-GLUCOSIDE AND PREPARATION METHOD THEREOF 审中-公开
    无定形Piceathanol 3'-O-葡萄糖苷及其制备方法

    公开(公告)号：EP3287466A1

    公开(公告)日：2018-02-28

    申请号：EP15889768.6

    申请日：2015-12-23

    申请人： KPC Pharmaceuticals, Inc.

    发明人： GONG, Yunqi ,  LI, Ying ,  FANG, Fang

    IPC分类号： C07H15/203 ,  C07H1/06 ,  A61K31/7034 ,  A61P9/00

    摘要： The present invention relates to the field of pharmaceutical chemistry. Disclosed are a new amorphous piceatannol 3'-O-glucoside, preparation method thereof, and pharmaceutical composition containing the same. The amorphous piceatannol 3'-O-glucoside has favorable performances in stability and solubility. The preparation method for the amorphous piceatannol 3'-O-glucoside in the present invention is easy to operate, and the resulting product has a high yield, and is suitable for development of a laboratory and industrial production, thus having a wide application. The amorphous piceatannol 3'-O-glucoside product prepared by the method in the present invention has a stable quality, a favorable solubility, and can be directly used to prepare medicine treating cardiovascular diseases and cerebrovascular diseases.

    摘要翻译： 本发明涉及药物化学领域。 本发明公开了一种新的无定形云杉鞣质3'-O-葡萄糖苷及其制备方法，以及含有该化合物的药物组合物。 无定形piceatannol 3'-O-葡萄糖苷具有良好的稳定性和溶解性。 本发明的无定形云杉萜醇3'-O-葡萄糖苷的制备方法操作简单，产品收率高，适用于实验室和工业生产的开发，具有广泛的应用。 本发明方法制备的无定形山an醇3'-O-葡萄糖苷产品质量稳定，溶解性好，可直接用于制备治疗心血管疾病和脑血管疾病的药物。

    METHOD FOR EXTRACTING STILBENE COMPOUNDS
    9.
    发明公开
    METHOD FOR EXTRACTING STILBENE COMPOUNDS 审中-公开
    提取斯蒂芬化合物的方法

    公开(公告)号：EP3243828A1

    公开(公告)日：2017-11-15

    申请号：EP15876716.0

    申请日：2015-12-30

    申请人： KPC Pharmaceuticals, Inc.

    发明人： GONG, Yunqi ,  CHEN, Jinxin ,  FANG, Fang

    IPC分类号： C07H15/203 ,  C07H1/08 ,  A61K36/708 ,  A61P9/00 ,  A61P25/28 ,  A61K125/00

    CPC分类号： A61K36/708 ,  A61K2236/00

    摘要： A method for extracting stilbene compounds comprises the following steps: grinding a medicinal material rich in stilbene compounds such as rheum officinale; extracting the medicinal material with a herbal flash extractor for one to four times, 5-20 minutes each time; filtering and combining filtrate and concentrating the filtrate to dryness; the proportion of the medicinal material to a solvent being 1 g: 10 ml-1 g:15 ml.

    摘要翻译： 提取二苯乙烯化合物的方法包括以下步骤：研磨富含s类化合物如大黄的药物材料; 用草药闪蒸提取器提取药材1至4次，每次5-20分钟; 过滤并合并滤液并将滤液浓缩至干燥; 药物与溶剂的比例为1g:10ml-1g:15ml。