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公开(公告)号：EP2117596B1
公开(公告)日：2018-01-03
申请号：EP07857604.8
申请日：2007-12-14
申请人： TIMA Foundation
IPC分类号： A23L33/15 , A23L33/175 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/375 , A61K31/455 , A61K31/525 , A61K45/06 , A61P3/10
CPC分类号： A61K31/198 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/375 , A61K31/455 , A61K31/525 , A61K45/06 , A23V2200/328 , A23V2250/0618 , A23V2250/0616 , A23V2250/7044 , A23V2250/7046 , A23V2250/036 , A23V2250/314 , A23V2250/708 , A23V2250/062
摘要： The present invention relates to compositions comprising glutamic acid and/or glutamine, cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, niacin, optionally vitamin C, and/or prodrugs of these substances and/or salts of these substances. The compositions can be used as food supplement and/or medicament for prophylaxis or treatment of several disease conditions, in particular of hyperglycemia and related diseases or disorders. Consequently, the present invention is also directed to pharmaceutical compositions for the use in human and veterinary medicine as well as method of treatments of said diseases.
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公开(公告)号：EP1994052A1
公开(公告)日：2008-11-26
申请号：EP07723200.7
申请日：2007-03-12
申请人： TIMA Foundation
CPC分类号： C07K14/4747
摘要： The present invention relates to a nucleic acid molecule encoding for IEX-1 polypeptide as a medicament. In a further aspect the present invention relates to a nucleic acid molecule encoding for IEX-1 polypeptide for the manufacture of a medicament for the treatment of gliomas.
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3.发明授权COMPOSITION FOR MODERATING ALCOHOL METABOLISM AND FOR REDUCING THE RISK OF ALCOHOL INDUCED DISEASES 有权组成控制酒精代谢和减少与酒精相关的疾病的风险
公开(公告)号：EP1909600B1
公开(公告)日：2012-04-25
申请号：EP06762860.2
申请日：2006-07-27
申请人： TIMA Foundation
IPC分类号： A23L1/303 , A23L1/29 , A23L1/302 , A23L1/305 , A61K45/06 , A61P25/32 , A61P25/02 , A61P1/16 , A61P1/04 , A61P1/18 , A61P35/00
CPC分类号： A61K31/525 , A23L33/15 , A23L33/155 , A23L33/175 , A23L33/30 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/341 , A61K31/375 , A61K31/445 , A61K31/455 , A61K45/06 , A23V2200/322 , A23V2250/7046 , A23V2250/708 , A23V2250/5114 , A23V2250/0618 , A23V2250/0616 , A23V2250/7044 , A23V2250/036 , A23V2250/062 , A61K2300/00 , A23V2250/61 , A23V2250/02
摘要： The present invention is directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively. The composition of matter reduces the risk of neuropathy, neurodegenerative diseases including late-onset Alzheimer´s disease, and cancer, in particular of pancreatic, esophageal, oropharyngolaryngeal, liver, colorectal, lung and/or breast cancer, in particular the drug and/or alcohol induced risk of said diseases. In this respect, the present invention is also directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively, which supports and/or moderates the alcohol degradation process within the human body.
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4.发明公开Composition for moderating Triglyceride and Cholesterol Levels 审中-公开Zusammensetzung zum Ausgleich von甘油三酯和胆固醇
公开(公告)号：EP2057905A1
公开(公告)日：2009-05-13
申请号：EP07120500.9
申请日：2007-11-12
申请人： TIMA Foundation
发明人： Inufusa, Haruhiko
IPC分类号： A23L1/03 , A61K31/122 , A61K31/198 , A61K31/225 , A61K31/375 , A61K31/455 , A61K31/525 , A61P3/06 , A61P15/00 , A61P15/10 , A61P9/10 , A61P43/00
CPC分类号： A61K31/525 , A23L33/10 , A23L33/15 , A23L33/175 , A61K31/122 , A61K31/198 , A61K31/225 , A61K31/375 , A61K31/455 , A61K2300/00
摘要： The present invention relates to the use of a composition comprising vitamin C, glutamic acid and/or glutamine, cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10 and niacin and/or prodrugs of these substances and/or salts of these substances for the manufacture of a food supplement or medicament for prophylaxis and/or treatment of hypertriglyceridemia and hypercholesterolemia and related disease states as well as erectile dysfunction.
摘要翻译： 本发明涉及包含这些物质的这些物质和/或这些物质的盐的维生素C，谷氨酸和/或谷氨酰胺，半胱氨酸，核黄素，琥珀酸，富马酸，辅酶Q10和烟酸和/或前药的组合物的用途， 制造用于预防和/或治疗高甘油三酯血症和高胆固醇血症以及相关疾病状态以及勃起功能障碍的食物补充剂或药物。
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5.发明公开COMPOSITION FOR PROTECTION AGAINST CELL-DAMAGING EFFECTS 有权ZUBEREITUNG ZUM SCHUTZ GEGENZELLSCHÄDIGENDEWIRKUNGEN
公开(公告)号：EP2779842A1
公开(公告)日：2014-09-24
申请号：EP12790523.0
申请日：2012-11-15
申请人： TIMA Foundation
发明人： INUFUSA, Haruhiko
IPC分类号： A23L1/03 , A61K31/122 , A61K31/198 , A61K31/225 , A61K31/375 , A61K31/455 , A61K31/522 , A61P39/06
CPC分类号： A61K31/375 , A23L33/10 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/455 , A61K31/519 , A61K31/525 , A61K31/52 , A61K2300/00 , A23V2200/02 , A23V2250/036 , A23V2250/0616 , A23V2250/0618 , A23V2250/314 , A23V2250/7044 , A23V2250/7046
摘要： The present invention relates to a composition consisting of Vitamin C, L-glutamine, L-cystine or L-cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, and niacin. The present invention relates further to the use of the composition for minimizing the cell-damaging effect of radicals and harmful forms of oxygen, in particular of oxygen radicals or reactive oxygen species. The present invention relates to a composition comprising Vitamin C, L-glutamine, L-cystine or L-cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, and niacin, wherein the composition is administered in a concentration ranging from 10 to 20 mg/kg body weight. The present invention relates further to the composition for use in the treatment and/or prevention of radical and harmful forms of oxygen derived diseases, in particular of oxygen radical or reactive oxygen species derived diseases. The present invention relates further to the composition as a food supplement or dietary supplement.
摘要翻译： 本发明涉及由维生素C，L-谷氨酰胺，L-胱氨酸或L-半胱氨酸，核黄素，琥珀酸，富马酸，辅酶Q10和烟酸组成的组合物。 本发明进一步涉及组合物用于最小化自由基和有害形式的氧，特别是氧自由基或活性氧的细胞破坏作用的用途。 本发明涉及包含维生素C，L-谷氨酰胺，L-胱氨酸或L-半胱氨酸，核黄素，琥珀酸，富马酸，辅酶Q10和烟酸的组合物，其中组合物以10至20的浓度施用 mg / kg体重。 本发明进一步涉及用于治疗和/或预防氧衍生疾病，特别是氧自由基或活性氧衍生疾病的自由基和有害形式的组合物。 本发明进一步涉及作为食物补充剂或膳食补充剂的组合物。
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公开(公告)号：EP2117596A2
公开(公告)日：2009-11-18
申请号：EP07857604.8
申请日：2007-12-14
申请人： TIMA Foundation
CPC分类号： A61K31/198 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/375 , A61K31/455 , A61K31/525 , A61K45/06 , A23V2200/328 , A23V2250/0618 , A23V2250/0616 , A23V2250/7044 , A23V2250/7046 , A23V2250/036 , A23V2250/314 , A23V2250/708 , A23V2250/062
摘要： The present invention relates to compositions comprising glutamic acid and/or glutamine, cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, niacin, optionally vitamin C, and/or prodrugs of these substances and/or salts of these substances. The compositions can be used as food supplement and/or medicament for prophylaxis or treatment of several disease conditions, in particular of hyperglycemia and related diseases or disorders. Consequently, the present invention is also directed to pharmaceutical compositions for the use in human and veterinary medicine as well as method of treatments of said diseases.
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7.发明公开COMPOSITION FOR MODERATING ALCOHOL METABOLISM AND FOR REDUCING THE RISK OF ALCOHOL INDUCED DISEASES 有权组成控制酒精代谢和减少与酒精相关的疾病的风险
公开(公告)号：EP1909600A1
公开(公告)日：2008-04-16
申请号：EP06762860.2
申请日：2006-07-27
申请人： TIMA Foundation
IPC分类号： A23L1/303 , A23L1/29 , A23L1/302 , A23L1/305 , A61K45/06 , A61P25/32 , A61P25/02 , A61P1/16 , A61P1/04 , A61P1/18 , A61P35/00
CPC分类号： A61K31/525 , A23L33/15 , A23L33/155 , A23L33/175 , A23L33/30 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/341 , A61K31/375 , A61K31/445 , A61K31/455 , A61K45/06 , A23V2200/322 , A23V2250/7046 , A23V2250/708 , A23V2250/5114 , A23V2250/0618 , A23V2250/0616 , A23V2250/7044 , A23V2250/036 , A23V2250/062 , A61K2300/00 , A23V2250/61 , A23V2250/02
摘要： The present invention is directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively. The composition of matter reduces the risk of neuropathy, neurodegenerative diseases including late-onset Alzheimer´s disease, and cancer, in particular of pancreatic, esophageal, oropharyngolaryngeal, liver, colorectal, lung and/or breast cancer, in particular the drug and/or alcohol induced risk of said diseases. In this respect, the present invention is also directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively, which supports and/or moderates the alcohol degradation process within the human body.
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公开(公告)号：EP2779842B1
公开(公告)日：2017-09-20
申请号：EP12790523.0
申请日：2012-11-15
申请人： TIMA Foundation
发明人： INUFUSA, Haruhiko
IPC分类号： A61K31/122 , A61K31/198
CPC分类号： A61K31/375 , A23L33/10 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K31/122 , A61K31/194 , A61K31/198 , A61K31/455 , A61K31/519 , A61K31/525 , A61K31/52 , A61K2300/00 , A23V2200/02 , A23V2250/036 , A23V2250/0616 , A23V2250/0618 , A23V2250/314 , A23V2250/7044 , A23V2250/7046
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9.发明公开Composition for protection against cell-damaging effects 审中-公开Zubereitung zum Schutz gegenzellschädigendeWirkungen
公开(公告)号：EP2594141A1
公开(公告)日：2013-05-22
申请号：EP11189191.7
申请日：2011-11-15
申请人： TIMA Foundation
发明人： Inufusa, Haruhiko
IPC分类号： A23L1/03 , A61K31/122 , A61K31/198 , A61K31/225 , A61K31/375 , A61K31/455 , A61K31/522 , A61P39/06
CPC分类号： A23L3/3463 , A61K31/122 , A61K31/198 , A61K31/225 , A61K31/375 , A61K31/455 , A61K31/522 , A61K2300/00
摘要： The present invention relates to the use of a composition comprising Vitamin C, L-glutamine, L-cystine or L-cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10, and niacin for minimizing the cell-damaging effect of radicals and harmful forms of oxygen, in particular of oxygen radicals or reactive oxygen species. The present invention relates further to the composition for use in the treatment and/or prevention of radical and harmful forms of oxygen derived diseases, in particular of oxygen radical or reactive oxygen species derived diseases. The present invention relates further to the composition as a food supplement or dietary supplement.
摘要翻译： 本发明涉及包含维生素C，L-谷氨酰胺，L-胱氨酸或L-半胱氨酸，核黄素，琥珀酸，富马酸，辅酶Q10和烟酸的组合物的用途，用于使自由基的细胞损伤作用最小化和有害 氧的形式，特别是氧自由基或活性氧的形式。 本发明进一步涉及用于治疗和/或预防氧衍生疾病，特别是氧自由基或活性氧衍生疾病的自由基和有害形式的组合物。 本发明进一步涉及作为食物补充剂或膳食补充剂的组合物。
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公开(公告)号：EP1932542A1
公开(公告)日：2008-06-18
申请号：EP06026072.6
申请日：2006-12-15
申请人： TIMA Foundation
CPC分类号： A61K31/198 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K31/191 , A61K31/194 , A61K31/22 , A61K31/375 , A61K31/445 , A61K31/525 , A61K2300/00 , A23V2200/322 , A23V2250/708 , A23V2250/062 , A23V2250/0618 , A23V2250/0616 , A23V2250/036 , A23V2250/314 , A23V2250/7046 , A23V2250/7044 , A23V2200/328
摘要： The present invention relates to a composition comprising Vitamin C, glutamic acid and/or glutamine, cysteine, riboflavin, succinic acid, fumaric acid, coenzyme Q10 and niacin. The composition can be used as food supplement and/or medicament for prophylaxis or treatment of several disease conditions. Consequently, the present invention is also directed to a pharmaceutical composition for the use in human and veterinary medicine.
摘要翻译： 本发明涉及包含维生素C，谷氨酸和/或谷氨酰胺，半胱氨酸，核黄素，琥珀酸，富马酸，辅酶Q10和烟酸的组合物。 该组合物可以用作预防或治疗几种疾病状况的食物补充剂和/或药物。 因此，本发明还涉及用于人和兽医学的药物组合物。
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