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    MODIFIED TRANSGLUTAMINASE
    1.
    发明公开
    MODIFIED TRANSGLUTAMINASE 审中-实审

    公开(公告)号：EP4414454A1

    公开(公告)日：2024-08-14

    申请号：EP22878632.3

    申请日：2022-10-07

    申请人： Amano Enzyme Inc.

    发明人： YOSHIDA, Kazunori ,  UEDA, Kenta

    IPC分类号： C12N15/54 ,  A23L33/175 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/63

    CPC分类号： A23L33/175 ,  C12N5/10 ,  C12N9/10 ,  C12N15/63 ,  C12N15/74 ,  C12N15/80 ,  C12N15/81

    摘要： The purpose of the present invention is to provide a modified transglutaminase that has improved reactivity in a heating temperature range. A transglutaminase, which includes a polypeptide having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 by: substitution of the combination of the three amino acid residues at the 249 to 251 positions by a combination of three predetermined amino acid residues; substitution of the combination of the three amino acid residues at the 243 to 245 positions by a combination of three predetermined amino acid residues; and/or substitution of the amino acid residue at the 2 position by a predetermined amino acid, has improved reactivity in a heating temperature range compared to the polypeptide having the amino acid sequence represented by SEQ ID NO: 1.