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公开(公告)号：EP4188445A1
公开(公告)日：2023-06-07
申请号：EP21758079.4
申请日：2021-08-02
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公开(公告)号：EP3685783A1
公开(公告)日：2020-07-29
申请号：EP19207282.5
申请日：2009-03-02
发明人： NEUBERGER, Wolfgang
IPC分类号： A61B18/24
摘要： An improved method and device are provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.
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公开(公告)号：EP1701726B1
公开(公告)日：2019-01-23
申请号：EP04782618.5
申请日：2004-08-30
发明人： ALBRECHT, Volker , GITTER, Burkhard
IPC分类号： A61K31/495 , A61K31/50 , A61P31/04
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公开(公告)号：EP3308734A1
公开(公告)日：2018-04-18
申请号：EP17195980.2
申请日：2017-10-11
发明人： KLAMANN, Karl
IPC分类号： A61B18/22 , A61B17/3211 , A61B18/20
CPC分类号： A61B18/22 , A61B17/3211 , A61B2018/2025 , A61B2018/2272
摘要： Optisches Skalpell (1) bestehend aus zumindest einem Lichtleiter (3), mit einem proximalen und einem, vom proximalen Ende (4) abgewendeten, distalen Ende (11), wobei an dessen proximalen Ende (4) zumindest eine erste Lichtquelle angeordnet ist, wobei das distale Ende (11) des Lichtleiters (3) als Skalpellendung (12) ausgebildet ist und die Skalpellendung (12) mit dem zumindest einem Lichtleiter (3) einstückig ausgebildet ist.
摘要翻译： 一种光学手术刀（1）由（3）背向具有近端的至少一个光导的和，从所述近端（4），所述远端（11），在近端（4）的至少一个第一光源设置，其中 光导（3）的远端（11）被设计为手术刀延伸部（12）和所述延伸部手术刀（12）一体地与所述至少一个光导（3）形成。
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公开(公告)号：EP1928466B1
公开(公告)日：2017-11-22
申请号：EP06813236.4
申请日：2006-07-27
IPC分类号： A61K8/49 , A61Q19/06 , A61K31/409 , A61K31/555
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： A photosensitizer mixture and a method of treating cellulites by means of a percutaneous application of the mixture into the area of cellulite buildup followed by light illumination are presented. The photosensitizer can be combined with one or more cellular products including adipose cells and/or collagen that have been previously removed by liposuction. This mixture can also include other compounds such as Lipofundin MCT 10% to improve the photosensitizer's diffusion or to dilute it Varying concentrations are used depending on the area of treatment as well as the stage of the cellulites and whether the cellulites present a depressed area in the skin or an elevated area. The cosmetic treatment method substantially reduces or removes localized lipodystrophies and/or flaccidity and/or cellulite by localized laser, LED or other light irradiation of the area of treatment having a photosensitizer applied therein. The light energy is applied to destroy the "fat" cells by a combination of chemical reactions, primarily, and temperature wherein the cell walls break releasing the cell fluid. The light radiation is generally applied through devices to guide the radiation to the area of treatment. One or more light sources such as laser diodes or LEDs may be coupled into one or more optical fibers to increase the area of coverage as well as increase the amount of radiation in that area of coverage. Optical fibers can be introduced percutaneously or possibly interstitially into the area of treatment. Cell fluid in the area of treatment is removed by a combination of techniques. Quick and lasting cosmetic changes in areas having prior untreatable cellulite fat tissues are achieved while minimizing trauma.
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公开(公告)号：EP3607905A1
公开(公告)日：2020-02-12
申请号：EP19188629.0
申请日：2007-09-12
发明人： NEUBERGER, Wolfgang
摘要： A device/system and a method for the treatment of varicose veins and other vein abnormalities are presented. In one preferred embodiment, the treatment comprises a combination of two wavelengths to effectively occlude abnormal veins. The wavelengths are chosen as the effective absorption peaks of hemoglobin and water, which are seen at these wavelengths, approximately 980 nm and 1460 nm respectively. The vein is targeted with these wavelengths to obtain maximum and effective absorption. The Near Infra Red laser radiations are delivered to blood, collagen and water in the vessel which results in occlusion and shrinkage of the vein. In this technique an optical fiber is inserted into the vein and laser sources are used to irradiate the vein. A control mechanism allows delivery of constant power density based on feedback about speed of fiber withdrawal and local structural vein parameters. This technique is an effective treatment for vein disorders as the treated vein is targeted with dual wavelengths of energy or alternatively with a wavelength having highly controlled vein-wall damage character. The treatment conditions are based on feedback from different control parameters that are monitored and preliminary predetermined structural parameters of the treatment site. The device involves a side firing optical fiber which can also irradiate nearly uniform circumferentially from said fiber's distal end. Alternatively, in another preferred embodiment 1460+60 nm laser energy is employed, which with its high absorption in the vein wall, creates little thermal stress outside the vein, and is very effective in initiating the damage reaction response, shrinkage in the vein wall. An example is using, e.g., a 1470±20 nm wavelength. Laser vein treatments administered using 1460 ± 60 nm have the benefits of high vein closure rates and extremely favorable post-operative results, i.e., little, if any, post-operative pain/discomfort, brusing or inflammatory reactions, due to their very high absorption in small volumes of the collagen/water in vein walls.
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公开(公告)号：EP2974687B1
公开(公告)日：2019-11-06
申请号：EP15181794.7
申请日：2009-03-02
发明人： NEUBERGER, Wolfgang
IPC分类号： A61B18/24
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公开(公告)号：EP2704796B1
公开(公告)日：2018-03-07
申请号：EP12779807.2
申请日：2012-05-04
CPC分类号： A61B18/22 , A61B18/24 , A61B2018/00559 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00982 , A61B2018/2255 , A61B2090/378 , A61B2218/001
摘要： Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.
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公开(公告)号：EP2870159B1
公开(公告)日：2017-06-28
申请号：EP11810524.6
申请日：2011-08-12
IPC分类号： C07D487/22 , A61K31/409 , A61P35/00 , A61P17/00
CPC分类号： A61K31/409 , C07D487/22
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公开(公告)号：EP2981225A4
公开(公告)日：2017-03-01
申请号：EP14779782
申请日：2014-04-01
发明人： NEUBERGER WOLFGANG
CPC分类号： A61B18/22 , A61B2018/00547 , A61B2018/00577 , A61B2018/00785 , A61B2018/00904 , A61B2018/2035 , A61B2018/2255 , A61B2018/2272 , A61B2018/2288
摘要： Improved device and method for safe, accurate, efficient surgical procedures are disclosed. A preferred device is a waveguide assembly for delivering electromagnetic radiation to a tissue comprising a waveguide with a multi-facetted tip and a cap over the 5 multi-facetted tip. Preferably the waveguide is an optical fiber. The cap is a protective, reinforced cap fused to the optical fiber's tip as an integral part of it and comprises an axially-extending portion oriented at a predetermined angle relative to the elongated axis of the optical fiber. A method of manufacturing special waveguide caps is provided. The optical fiber assembly delivers high power electromagnetic radiation in lateral direction 10 with respect to the elongated axis of the optical fiber, determined by the multiple-facetted tip, the slant angles of the optical fiber's core, and the orientation of the cap's axially-extending portion. A method for removing unwanted tissue like in benign prostatic hyperplasia treatments is also provided.
摘要翻译： 公开了用于安全，准确，有效的外科手术的改进的装置和方法。 优选的装置是用于将电磁辐射传送到包括波导的组织的波导组件，所述波导具有多面刻面和覆盖在5个多面尖端上的盖。 优选地，波导是光纤。 盖是作为其光纤的尖端熔合的保护性增强的盖，作为其整体部分，并且包括相对于光纤的细长轴线以预定角度定向的轴向延伸部分。 提供制造特殊波导盖的方法。 光纤组件相对于光纤的细长轴线在横向方向10上传递高功率电磁辐射，由多面尖端确定，光纤芯的倾斜角度以及盖的轴向延伸方向 一部分。 还提供了用于去除良性前列腺增生治疗中的不想要的组织的方法。
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