利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.015 秒)

    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY
    3.
    发明公开
    CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY 审中-公开
    卟啉类光敏剂与甘油基聚合物共轭用于光动力疗法

    公开(公告)号：EP3210626A1

    公开(公告)日：2017-08-30

    申请号：EP17158001.2

    申请日：2017-02-24

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： STAEGEMANN, Michael ,  HAAG, Rainer ,  WIEHE, Arno ,  GRÄFE, Susanna ,  GITTER, Burkhard ,  ALBRECHT, Volker

    IPC分类号： A61K41/00 ,  C07D403/14 ,  A61P35/00

    CPC分类号： C07D487/22 ,  A61K41/0071 ,  A61K47/60 ,  C07D403/14 ,  C08G65/48

    摘要： Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. In addition, conjugates are provided in which these photosensitizers are attached to water-soluble polymers via cleavable linkers that can be cleaved in the body under specific conditions. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

    摘要翻译： 可用作诊断和治疗应用的光敏剂的生物活性化合物，特别是用于癌症的PDT，感染和其他过度增殖性疾病，非肿瘤性适应症如关节炎，炎性疾病，病毒或细菌感染的荧光诊断和PDT治疗， 提供皮肤病，眼科或泌尿系统疾病以及提供获得药物质量的方法。 此外，提供了这样的缀合物，其中这些光敏剂经由可在特定条件下在体内裂解的可切割连接物连接至水溶性聚合物。 另一个实施方案包括将所需的四吡咯光敏剂配制成药物制剂以注射到体内，避免不希望的效应，例如四吡咯系统的溶解度问题或延迟的药代动力学。

    APPLICATION OF METAL COMPLEXES IN ANTI-TUMOR AND ANTI-BACTERIAL THERAPY
    6.
    发明公开
    APPLICATION OF METAL COMPLEXES IN ANTI-TUMOR AND ANTI-BACTERIAL THERAPY 审中-公开

    公开(公告)号：EP3521295A1

    公开(公告)日：2019-08-07

    申请号：EP19155178.7

    申请日：2019-02-02

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： GUTSCHE, Claudia Simone ,  WIEHE, Arno ,  HOHLFELD, Benjamin Florian ,  GITTER, Burkhard ,  ALBRECHT, Volker

    IPC分类号： C07F15/04 ,  A61P35/00 ,  A61K31/28 ,  A61K31/295 ,  A61K31/315 ,  C07F15/00 ,  C07F15/02 ,  C07F1/08 ,  C07F3/06 ,  C07F5/00 ,  G01N33/574

    摘要： The present invention provides biologically active compounds and methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Preferred embodiments of the present invention consist of methods to synthesize metal or half-metal complex structures incorporating one or more substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) units. These dipyrromethenes (dipyrrins) can carry a variety of different substituents in the 4-position enabling a fine tuning of their biological or amphiphilic/hydrophilic properties. Another object of the present invention is to provide amphiphilic compounds with a higher membrane affinity and increased efficacy.

    NOVEL METHOD AND APPLICATION OF UNSYMMETRICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PDT
    7.
    发明公开
    NOVEL METHOD AND APPLICATION OF UNSYMMETRICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PDT 审中-公开

    公开(公告)号：EP3459955A1

    公开(公告)日：2019-03-27

    申请号：EP18202127.9

    申请日：2009-09-17

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： WIEHE, Arno ,  AICHER, Daniel ,  STARK, Christian, B. W. ,  GRÄFE, Susanna

    IPC分类号： C07D487/22 ,  C07H15/26 ,  A61K31/40 ,  A61K31/409 ,  A61P35/00

    摘要： Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In another embodiment a method to reductively cleave the osmate(VI)ester avoiding the use of gaseous H 2 S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

    NOVEL METHOD AND APPLICATION OF UNSYMMETRICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PDT
    10.
    发明授权
    NOVEL METHOD AND APPLICATION OF UNSYMMETRICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PDT 有权

    公开(公告)号：EP2350058B1

    公开(公告)日：2018-10-24

    申请号：EP09815180.6

    申请日：2009-09-17

    申请人： biolitec Unternehmensbeteiligungs II AG

    发明人： WIEHE, Arno ,  AICHER, Daniel ,  STARK, Christian, B., W. ,  GRÄFE, Susanna

    IPC分类号： C07D487/22 ,  C07H15/26 ,  A61K31/40 ,  A61K31/409 ,  A61P35/00

    CPC分类号： C07D487/22 ,  C07H15/26

    摘要： Biologically active compounds are provided that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In another embodiment a method to reductively cleave the osmate(VI)ester avoiding the use of gaseous H2S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.