公开(公告)号：EP2809787B8

公开(公告)日：2018-11-28

申请号：EP13743957.6

申请日：2013-02-01

申请人： Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET) ,  Universidad Nacional del Litoral ,  Inis Biotech LLC ,  Chan, Raquel Lia ,  Cabello, Julieta Virginia ,  Giacomelli, Jorge Ignacio

发明人： CHAN, Raquel Lia ,  CABELLO, Julieta Virginia ,  GIACOMELLI, Jorge Ignacio

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N5/04 ,  C12N15/00

CPC分类号： C12N15/8273 ,  C07K14/415 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

摘要： The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operably associated with the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.

公开(公告)号：EP2809787A1

公开(公告)日：2014-12-10

申请号：EP13743957.6

申请日：2013-02-01

申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) ,  Unl - Universidad Nacional Del Litoral ,  Inis Biotech LLC ,  Chan, Raquel Lia ,  Cabello, Julieta Virginia ,  Giacomelli, Jorge Ignacio

发明人： CHAN, Raquel Lia ,  CABELLO, Julieta Virginia ,  GIACOMELLI, Jorge Ignacio

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N5/04 ,  C12N15/00

CPC分类号： C12N15/8273 ,  C07K14/415 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

摘要： The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operably associated with the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.

公开(公告)号：EP3156068A1

公开(公告)日：2017-04-19

申请号：EP16002285.1

申请日：2011-03-29

申请人： CNRS (Centre National de la Recherche Scientifique) ,  Université Pierre et Marie Curie (Paris 6) ,  Assistance Publique Hôpitaux de Paris ,  CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) ,  Universidad Católica de Córdoba (UCC)

发明人： Klatzmann, David ,  Piaggio, Eliane ,  Lujan, Hugo

IPC分类号： A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  C07K14/11 ,  C07K14/145 ,  C07K14/44 ,  C12N7/00

CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/542 ,  A61K2039/6031 ,  B82Y5/00 ,  C07K14/44 ,  C07K2319/00 ,  C12N7/00 ,  C12N2740/13023 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2810/6072 ,  Y02A50/412 ,  Y02A50/491 ,  Y10S977/773

摘要： The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasite's variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.

摘要翻译： 本发明涉及使用多肽，其包含至少一个CXXC基序，颜色的药物组合物：如贾第虫属寄生虫的可变表面蛋白（VSP）或其片段通过在不受异源所选抗原的免疫应答，：如肿瘤抗原口服或粘膜接种疫苗，以提高 ，微生物抗原或其它抗原。

公开(公告)号：EP2552476B1

公开(公告)日：2016-12-07

申请号：EP11710794.6

申请日：2011-03-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  Université Pierre et Marie Curie (Paris 6) ,  Assistance Publique Hôpitaux De Paris ,  CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) ,  Universidad Católica de Córdoba (UCC)

发明人： KLATZMANN, David ,  PIAGGIO, Eliane ,  LUJAN, Hugo

IPC分类号： A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  C07K14/11 ,  C07K14/14 ,  C07K14/44 ,  C12N7/00

CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/542 ,  A61K2039/6031 ,  B82Y5/00 ,  C07K14/44 ,  C07K2319/00 ,  C12N7/00 ,  C12N2740/13023 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2810/6072 ,  Y02A50/412 ,  Y02A50/491 ,  Y10S977/773

摘要： The invention relates to pharmaceutical compositions using a polypeptide comprising at least one CXXC motif, such as Giardia parasite's variable surface proteins (VSP) or a fragment thereof to raise by oral or mucosal vaccination an immune response against a heterologous selected antigen, such as tumor antigen, microbial antigen or other antigen.

公开(公告)号：EP2802558A1

公开(公告)日：2014-11-19

申请号：EP13709265.6

申请日：2013-01-10

申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) ,  Laboratorios Richmond Sociedad Anónima Comercial Industrial y Financiera

发明人： BURTON, Gerardo ,  DURÁN, Fernando ,  MARTINEZ, Mario ,  ZINI, Elvira ,  MORA MUÑOZ, Veronica

IPC分类号： C07C259/08 ,  C07D213/81 ,  C07C235/34 ,  C07C235/38 ,  C07D295/185 ,  A61K31/165 ,  A61K31/5375 ,  A61K31/4409 ,  A61P31/04

CPC分类号： C07D213/86 ,  C07C51/347 ,  C07C51/60 ,  C07C231/02 ,  C07C235/34 ,  C07C235/38 ,  C07C259/08 ,  C07C2601/14 ,  C07D213/81 ,  C07D295/185

摘要： A compound of the structural formula I, a pharmaceutically acceptable salt, prodrug or derivative thereof, characterized in that R
1 is selected from H, a linear or branched (C1-C5) alkyl group and a COR
4 group; R
2 is selected from H, a linear or branched (C1-C5) alkyl group and a COR
5 group; R
3 is selected from H, a linear or branched (C1-C5) alkyl group, a linear or branched (C1-C5)- O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or an aryl substituted with one or more R
6 groups and an NHCOR
5 group, or the R
2 and R
3 groups together with N may form a substituted or unsubstituted piperidine, morpholine or piperazine group; R
4 is selected from H and a (C1-C5) alkyl group; R
5 is selected from an unsubstituted aryl group or an aryl group substituted with one or more R
6 , linear or branched (C1-C5) alkyl or pyridyne groups and a pyridine group; R
6 is selected from (C1-C5) alkyl groups, halogen and nitro, provided that R
1 , R
2 and R
3 are not H atoms at the same time. The compounds present antibacterial activity. Process for their preparation and pharmaceutical compositions comprising them are also disclosed.

摘要翻译： 药学上可接受的盐，前药或将式I的衍生物的化合物，其中R 1选自H，一（C1-C5）烷基和COR4基团; R 2选自H，一个（C1-C5）烷基和COR5组; R 3选自H，一（C1-C5）烷基，（C1-C5）-O-烷基，一个环烷基（C5-C6）碳原子的芳基，和在芳基（C1-C5） 烷基worin的芳基可以是在unsubstituiertem芳基或与一个或多个R 6基团和至NHCOR5组substituiertem，或R 2和R 3基团与N一起可形成哌啶，吗啉或哌嗪基; R 4选自H和（C1-C5）烷基; R5选自芳基在unsubstituiertem substituiertem选择或与一个或多个R 6，直链或支链的（C1-C5）烷基或pyridyne基和吡啶基; R 6选自（C1-C5）烷基，卤素和硝基。

公开(公告)号：EP2800817A1

公开(公告)日：2014-11-12

申请号：EP13700010.5

申请日：2013-01-04

申请人： Universidad Nacional de Rosario ,  Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET)

发明人： PALATNIK, Javier ,  RODRIGUEZ, Ramiro ,  MECCHIA, Martin ,  DEBERNANDI, Juan Manuel

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C12N15/8261 ,  C07K14/415 ,  C12N15/8202 ,  C12N15/8218 ,  C12N15/8266 ,  C12N15/8273 ,  Y02A40/146

摘要： The present disclosure provides a novel modified gene, rGRF3, or an ortholog thereof, which is shown to be decoupled from control by miR396, particularly in the presence of over-expression of at least one GIF gene, such as GIF1, AtGIF 2, AtGIF 3, Os11g40100, Os12g31350, Os03g52320 or combinations thereof. When present in a plant, the rGRF3 results in a phenotype of increased productivity (e.g. increased yield, increased biomass, increased stress resistance, increased seed production, increased seed yield, increased root growth, increased root elongation speed, delayed leaf senescence or increased drought tolerance and combinations thereof).

摘要翻译： 本公开提供了一种新的修饰基因rGRF3或其直向同源物，其显示与miR396的对照分离，特别是在至少一种GIF基因如GIF1，AtGIF2，AtGIF的过表达存在下 3，Os11g40100，Os12g31350，Os03g52320或其组合。 当存在于植物中时，rGRF3产生增加生产力的表型（例如增加的产量，增加的生物量，增加的胁迫抗性，增加的种子产量，增加的种子产量，增加的根生长，增加的根伸长速度，延迟的叶衰老或增加的干旱 公差及其组合）。

公开(公告)号：EP2809787B1

公开(公告)日：2018-10-17

申请号：EP13743957.6

申请日：2013-02-01

申请人： CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TÉCNICAS (CONICET) ,  Universidad Nacional de Litoral (UNL) ,  Inis Biotech LLC ,  Chan, Raquel Lia ,  Cabello, Julieta Virginia ,  Giacomelli, Jorge Ignacio

发明人： CHAN, Raquel Lia ,  CABELLO, Julieta Virginia ,  GIACOMELLI, Jorge Ignacio

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N5/04 ,  C12N15/00

CPC分类号： C12N15/8273 ,  C07K14/415 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

摘要： The present invention provides isolated HaHB11 polypeptides and nucleic acids encoding the same. Also provided are methods of introducing a nucleic acid encoding HaHB11 polypeptides into a plant cell, plant part or plant, e.g., to increase tolerance to abiotic stress, to delay development and/or prolong the life span of a plant, and/or to increase yield from the plant. The invention also provides nucleic acids comprising HaHB11 promoter sequences and methods for expressing a nucleotide sequence of interest operably associated with the HaHB11 promoters of the invention in a plant cell, plant part, or plant. Also provided are transformed plants, plant tissues, plant cells and plant seed comprising the nucleic acids, expression cassettes and vectors of the invention.