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    SELF-EXPANDABLE BIODEGRADABLE STENT MADE OF CLAD RADIOPAQUE FIBERS COVERED WITH BIODEGRADABLE ELASTIC FOIL AND THERAPEUTIC AGENT AND METHOD OF PREPARATION THEREOF
    2.
    发明公开
    SELF-EXPANDABLE BIODEGRADABLE STENT MADE OF CLAD RADIOPAQUE FIBERS COVERED WITH BIODEGRADABLE ELASTIC FOIL AND THERAPEUTIC AGENT AND METHOD OF PREPARATION THEREOF 审中-公开
    根据上述制造可生物降解的柔性薄膜涂层纤维补救办法和可生物降解过程自膨式支架OFF X SEAL

    公开(公告)号：EP2747800A1

    公开(公告)日：2014-07-02

    申请号：EP11785279.8

    申请日：2011-08-26

    申请人： Ella-CS, s.r.o.

    发明人： RECMAN, Lukas ,  SEDMIKOVA, Barbora

    IPC分类号： A61L31/10 ,  A61L31/18

    CPC分类号： A61L31/10 ,  A61L31/148 ,  A61L31/18

    摘要： Self-expanding biodegradable stent comprising a base structure consisting of interlaced biodegradable fibres, characterized in that the core polymeric fibre containing an x-ray opaque filler is covered with an additional polymer, or the polymeric core fibre is provided with a uniformly dispersed x-ray opaque matter, or the polymeric core fibre is coated with a polymer in which an x-ray opaque matter is uniformly dispersed, the interlaced fibres forming the complete basic structure of the stent being also coated with a dispersion of a an x-ray opaque filler and with a polymer, said coatings forming a biodegradable foil provided on the basic structure of the stent and encapsulating an active substance, said active substance being selected from the group of substances including medicaments; proteins, enzymes/genes; stem cells or radioactive substances used for the Ideal treatment of tumors. 2. Method of manufacturing a self-expanding biodegradable stent having a base structure consisting of interlaced biodegradable fibres, characterized sn that it comprises the steps of covering the core polymeric fibre containing an x-ray opaque filler with an additional polymer, or providing the polymeric core fibre with a uniformly dispersed x-ray opaque matter, or coating the polymeric core fibre with a polymer in which an x-ray opaque matter is uniformly dispersed, followed by the step of coating the interlaced fibres forming the complete basic structure of the stent with a dispersion of a an x-ray opaque filler and with a polymer in order to provide a biodegradable foil on the basic structure of the stent, in which foil an active substance is encapsulated, in which step the stent provided with an x-ray opaque filler undergoes heat treatment and then it is coated with a biodegradable elastic foil made of x-ray opaque fibres containing a first medicament and after having been prepared in this manner the stent is subjected to heat treatment for the second time and recoated with a further, thinner biodegradable foil containing a second, different medicament.

    SELF-EXPANDABLE DOUBLE PLASTIC STENT
    3.
    发明公开
    SELF-EXPANDABLE DOUBLE PLASTIC STENT 审中-公开
    SELBSTAUSDEHNENDER DOPPELKUNSTSTOFFSTENT

    公开(公告)号：EP2747704A1

    公开(公告)日：2014-07-02

    申请号：EP11785280.6

    申请日：2011-08-26

    申请人： Ella-CS, s.r.o.

    发明人： VOLENEC, Karel ,  KUBENA, Petr

    IPC分类号： A61F2/04 ,  A61F2/86

    CPC分类号： A61F2/86 ,  A61F2/848 ,  A61F2002/044 ,  A61F2002/8483 ,  A61F2220/005 ,  A61F2250/0032 ,  A61F2250/0098

    摘要： A self - expanding non - degradable dual plastic stent being conical in shape is provided with an anti -migration segment (4) and with extracting wires at its proximal end and with an anti-reflux valve (6) at its distal end. The stent is made of two different non - degradable fibres, namely of the PEEK-based carrying fibre (2) and the radiopaque fibre (3), and coated with a silicone foil, the carrying fibre (2) forming the principal skeleton of the stent (1) and the radiopaque fibre (3) enhancing the visibility of the same, the carrying fibre (2) being made of a plastic material selected from the group including PEEK, PEAK, PEK, PEKK, PEKKEK and the other fibre being made of PU+W. The stent (1) is further provided with a pull -tie (5). A method of manufacturing said non - degradable dual conical plastic stent is described, wherein initially the stent is knitted from the first fibre by means of a braiding machine so that it assumes a tubular/ slightly conical shape having the proximal end atraumatic and the distal end traumatic, then the skeleton of the stent is placed oh a mandrel and the other, 1 radiopaque fibre is enlaced into it, both the fibres being laid side by side, afterwards the mandrel with the stent attached to it is removed from the braiding machine and placed into a thermal device where the shape of the stent is thermally fixated by being subjected to a temperature between 120 °C and 250 °C, preferably between 140 °C and 200 °C, during a time interval from 10 to 120 minutes, preferably from 20 to 40 minutes, and finally the stent is provided with the anti -migration segment at its proximal end, said segment comprising one or more fibres forming a ripple at the proximal end of the stent, said ripple adjoining the skeleton of the stent from outside.

    摘要翻译： 形成锥形的自扩张不可降解的双层塑料支架设置有防移动部分（4），并且在其近端具有拔出线并且在其远端具有防回流阀（6）。 支架由两种不同的不可降解纤维制成，即基于PEEK的携带纤维（2）和不透射线纤维（3），并涂有硅胶箔，载体纤维（2）形成主骨架 支架（1）和不透射线纤维（3）增强其可视性，载体纤维（2）由选自包括PEEK，PEAK，PEK，PEKK，PEKKEK和另一种纤维的组合的塑料材料制成 的PU + W。 支架（1）还具有拉头（5）。 描述了制造所述不可降解的双锥形塑料支架的方法，其中最初通过编织机从第一纤维编织支架，使得其呈现出具有近端无创伤和远端的管状/稍微圆锥形的形状 外伤后，将支架的骨架放置在心轴上，将另一个不透射线的纤维放入其中，两个纤维并排放置，然后将支架附着于其上的心轴从编织机中取出， 放置在热装置中，其中支架的形状通过在10至120分钟的时间间隔内经受120℃至250℃，优选140℃至200℃的温度而被热固定，优选地 20至40分钟，最后支架在其近端处设有防移植部分，所述部分包括一根或多根纤维，在支架近端形成纹波，所述纹波 从外部邻接支架的骨架。

    Biodegradable stent
    4.
    发明公开
    Biodegradable stent 审中-公开
    Biologisch abbaubarer支架

    公开(公告)号：EP2283794A1

    公开(公告)日：2011-02-16

    申请号：EP09466026.3

    申请日：2009-12-16

    申请人： Ella-CS, s.r.o.

    发明人： Petr, Kubena Petr ,  Semiková, Barbora

    IPC分类号： A61F2/90

    CPC分类号： A61F2/90 ,  A61F2210/0004 ,  A61F2250/0039

    摘要： The surface of the biodegradable stent is made as complex fine mesh in shape of rounded ( 2.1 ) rings ( 2 ) and the stent is tubular or conical. Favourably the stent will be made of degradable polymer thread and can be covered externally by the biodegradable covering.

    摘要翻译： 可生物降解支架的表面制成圆形（2.1）环（2）形状的复杂细网，支架为管状或圆锥形。 有利地，支架将由可降解的聚合物线制成，并且可以由可生物降解的覆盖物外部覆盖。