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    25-Hydroxyvitamin D3-1a-hydroxylase and dna encoding the hydroxylase
    3.
    发明公开
    25-Hydroxyvitamin D3-1a-hydroxylase and dna encoding the hydroxylase 失效
    25-羟基维生素D3-1A-羟化酶和dafürkodierende DNS

    公开(公告)号：EP0890643A2

    公开(公告)日：1999-01-13

    申请号：EP98112865.5

    申请日：1998-07-10

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： Anazawa, Hideharu ,  Shimada, Hiroko ,  Sugimoto, Seiji

    IPC分类号： C12N15/53 ,  C12N9/02 ,  C07K16/40 ,  A61K39/395 ,  A61K38/44 ,  C12Q1/68 ,  C12Q1/26

    CPC分类号： C12N9/0071 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00

    摘要： The present invention relates to a polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, being useful for the prevention, diagnosis and therapeutic treatment of adult diseases such as osteoporosis induced by the decrease of active type vitamin D 3 and catalyzing the final stage of vitamin D 3 activation; and the gene encoding the polypeptide.
    In accordance with the present invention, the following can be provided; a polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, DNA encoding the polypeptide, a recombinant DNA prepared by inserting the DNA in a vector, a transformant carrying the recombinant DNA, a method for preparing 25-hydroxyvitamin D 3 -1α-hydroxylase by using the transformant, a method for preparing 1α, 25-dihydroxyvitamin D 3 comprising using the polypeptide having 25-hydroxyvitamin D 3 -1α-hydroxylase activity, and an antibody recognizing the polypeptide.

    摘要翻译： 本发明涉及具有25-羟基维生素D3-1α-羟化酶活性的多肽，可用于预防，诊断和治疗成人疾病如由活性型维生素D3减少引起的骨质疏松症并催化最终阶段 维生素D3激活; 和编码多肽的基因。 根据本发明，可以提供以下内容： 具有25-羟基维生素D3-1α-羟化酶活性的多肽，编码该多肽的DNA，通过将DNA插入载体制备的重组DNA，携带重组DNA的转化体，制备25-羟基维生素D3-1α-羟化维生素D3-1α-羟化酶活性的方法， 通过使用转化体的羟化酶，制备包含使用具有25-羟基维生素D3-1α-羟化酶活性的多肽的1α，25-二羟基维生素D 3的方法和识别该多肽的抗体。

    DEPRESSION REMEDY
    6.
    发明公开
    DEPRESSION REMEDY 失效
    沮丧的补救措施

    公开(公告)号：EP0667349A1

    公开(公告)日：1995-08-16

    申请号：EP94925620.0

    申请日：1994-09-02

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： SUZUKI, Fumio ,  KOIKE, Nobuaki ,  SHIMADA, Junichi ,  KITAMURA, Shigeto ,  ICHIKAWA, Shunji ,  NAKAMURA, Joji ,  SHIOZAKI, Shizuo

    IPC分类号： C07D487/04 ,  A61K31/53

    CPC分类号： C07D487/04 ,  A61K31/53

    摘要： A depression remedy containing a triazine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof as the active ingredient, wherein R 1 represents hydrogen, (un)substituted lower alkyl or (un)substituted lower alkanoyl; R 2 represents hydrogen, (un)substituted lower alkyl, (un)substituted lower alkenyl, (un)substituted cycloalkyl, (un)substituted aryl, (un)substituted aralkyl or (un)substituted heterocycle; R 3 represents (un)substituted heterocycle; X represents a single bond, O, S, S(O), S(O) 2 or NR 4 , wherein R 4 represents hydrogen or (un)substituted lower alkyl or R 2 and NR 4 are combined with each other to form a 4- to 6-membered (un)substituted nitrogeneous saturated heterocyclic group; and A represents N or CR 5 , wherein R 5 represents hydrogen or (un)substituted lower alkyl.

    摘要翻译： （I）表示的三嗪衍生物或其药理学上可接受的盐作为有效成分的抑郁症药物，其中R1表示氢，（未）取代的低级烷基或（未）取代的低级烷酰基; （未）取代的低级链烯基，（未）取代的环烷基，（未）取代的芳基，（未）取代的芳烷基或（未）取代的杂环; R3代表（未）取代的杂环; X表示单键，O，S，S（O），S（O）2或NR 4，其中R 4表示氢或（未）取代的低级烷基或R 2和NR 4彼此结合形成4-6 （未）取代的氮杂饱和杂环基; A代表N或CR5，其中R5代表氢或（未）取代的低级烷基。

    $g(a)-2,8-SIALYLTRANSFERASE
    7.
    发明公开
    $g(a)-2,8-SIALYLTRANSFERASE 失效
    alpha-2,8 SIALYLTRANSFERASE

    公开(公告)号：EP0654529A1

    公开(公告)日：1995-05-24

    申请号：EP94910546.4

    申请日：1994-03-28

    申请人： KYOWA HAKKO KOGYO KABUSHIKI KAISHA

    发明人： SASAKI, Katsutoshi ,  KURATA, Kazumi ,  HANAI, Nobuo ,  NISHI, Tatsunari

    IPC分类号： C12N9/10

    CPC分类号： C12N9/1081

    摘要： A novel α-2,8-sialyltransferase which is expressed by the gene cloned from animal cells; a cDNA coding for the transferase; a method of detecting α-2,8-sialyltransferase using the cDNA and inhibiting the production of the transferase; a recombinant vector containing the cDNA integrated thereinto; a cell containing the vector; and processes for producing the above. The α-2,8-sialyltransferase invented is useful for producing physiologically active sugar chains, such as ganglioside GD3, and modification thereof.

    摘要翻译： 由从动物细胞克隆的基因表达的新型α-2.8唾液酸转移酶; 编码转移酶的cDNA; 使用cDNA检测α-2,3-唾液酸转移酶并抑制转移酶的产生的方法; 包含其中整合的cDNA的重组载体; 含有载体的细胞; 以及制造上述方法。 发明的α-2,3-唾液酸转移酶可用于生产生物活性糖链，例如神经节苷脂GD3及其修饰。