公开(公告)号：EP3881323A1

公开(公告)日：2021-09-22

申请号：EP19885524.9

申请日：2019-11-12

申请人： Myriad Genetics, Inc.

发明人： ZHARKIKH, Andrey ,  TIMMS, Kirsten ,  PERRY, Michael ,  GUTIN, Alexander

IPC分类号： G16B20/00 ,  G16B20/20 ,  G16B30/00 ,  G16B40/00

公开(公告)号：EP3693475A1

公开(公告)日：2020-08-12

申请号：EP19216740.1

申请日：2014-04-04

申请人： Myriad Genetics, Inc.

发明人： ABKEVICH, Victor ,  TIMMS, Kirsten ,  GUTIN, Alexander

IPC分类号： C12Q1/6886 ,  G16B20/00 ,  G01N33/15

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell ( e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells ( e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：EP3693473A1

公开(公告)日：2020-08-12

申请号：EP19216734.4

申请日：2012-06-15

申请人： Myriad Genetics, Inc.

发明人： GUTIN, Alexander ,  TIMMS, Kirsten ,  LANCHBURY, Jerry

IPC分类号： C12Q1/6827 ,  C12N15/11 ,  C12Q1/6858

摘要： Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided.

公开(公告)号：EP2981624B1

公开(公告)日：2019-12-18

申请号：EP14779403.6

申请日：2014-04-04

申请人： Myriad Genetics, Inc.

发明人： ABKEVICH, Victor ,  TIMMS, Kirsten ,  GUTIN, Alexander

IPC分类号： C12Q1/6886

公开(公告)号：EP2721181B1

公开(公告)日：2019-12-18

申请号：EP12801070.9

申请日：2012-06-15

申请人： Myriad Genetics, Inc.

发明人： GUTIN, Alexander ,  TIMMS, Kirsten ,  LANCHBURY, Jerry

IPC分类号： C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6883 ,  C12Q1/6874 ,  G16B30/00

公开(公告)号：EP3400312A1

公开(公告)日：2018-11-14

申请号：EP17736421.3

申请日：2017-01-06

申请人： Myriad Genetics, Inc. ,  Flake, Darl ,  Gutin, Alexander ,  Adams, Douglas

发明人： FLAKE, Darl ,  GUTIN, Alexander ,  ADAMS, Douglas

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Panels of biomarkers, methods and systems are disclosed for determining gene expression, and diagnosing and treating melanoma.

公开(公告)号：EP3230472A4

公开(公告)日：2018-06-13

申请号：EP15866475

申请日：2015-12-08

申请人： MYRIAD GENETICS INC ,  TESARO INC

发明人： WILCOXEN KEITH ,  LANCHBURY JERRY ,  GUTIN ALEXANDER ,  TIMMS KIRSTEN ,  ABKEVICH VICTOR ,  WANG YAN

IPC分类号： C12Q1/68 ,  A61K31/416 ,  G06F19/22

CPC分类号： C12Q1/6886 ,  A61K31/454 ,  C12Q2600/106 ,  C12Q2600/158

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature to predict response to niraparib. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature to predict response to niraparib are provided.

公开(公告)号：EP3327148A1

公开(公告)日：2018-05-30

申请号：EP17194403.6

申请日：2011-06-17

申请人： Myriad Genetics, Inc.

发明人： ABKEVICH, Victor ,  GUTIN, Alexander ,  TIMMS, Kirsten ,  LANCHBURY, Jerry

IPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12N15/11 ,  C12N5/09 ,  G06F19/18

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/18 ,  C12Q2537/16

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：EP2958999A4

公开(公告)日：2016-10-19

申请号：EP14754889

申请日：2014-02-21

申请人： MYRIAD GENETICS INC ,  WAGNER SUSANNE ,  STONE STEVEN ,  GUTIN ALEXANDER ,  REID JULIA

发明人： WAGNER SUSANNE ,  STONE STEVEN ,  GUTIN ALEXANDER ,  REID JULIA

IPC分类号： C12N15/11 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

公开(公告)号：EP3012329A1

公开(公告)日：2016-04-27

申请号：EP15189527.3

申请日：2011-06-17

申请人： Myriad Genetics, Inc. ,  Abkevich, Victor ,  Gutin, Alexander ,  Timms, Kirsten ,  Lanchbury, Jerry

发明人： ABKEVICH, Victor ,  GUTIN, Alexander ,  TIMMS, Kirsten ,  LANCHBURY, Jerry

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N5/09 ,  G06F19/18

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/18 ,  C12Q2537/16

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

摘要翻译： 本文件提供了评估样品（例如癌细胞）中存在杂合性（LOH）特征丧失的方法和材料。 例如，提供了用于确定细胞（例如癌细胞）是否含有LOH特征的方法和材料。 还提供了用于鉴定具有同源性定向修复（HDR）缺陷的细胞（例如癌细胞）的材料和方法以及用于鉴定可能对特定癌症治疗方案作出反应的癌症患者的材料和方法。