-
公开(公告)号：EP2841919B1
公开(公告)日：2018-11-21
申请号：EP13719520.2
申请日：2013-04-25
发明人： KURTZ, Georg , LOPEZ-CALLE, Eloisa
CPC分类号： G01N33/54393 , G01D18/00 , G01N21/274 , G01N21/63 , G01N21/78 , G01N21/82 , G01N33/52 , G01N33/54313 , G01N33/54346 , G01N33/573 , G01N33/6827 , G01N33/92 , G01N2021/825 , G06F19/18 , G16H50/30 , Y02A90/26
摘要： The present invention relates to a method for determining the amount of the specific analyte of a sample which may show interferences by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte of a sample to be determined, the measurement results are deposited in a data management system of the instrument platform. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample to be determined. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte of a sample to be determined is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. Finally, the amount of the specific analyte of a sample to be determined is quantified by comparison with the selected calibration curve for the chosen wavelengths.
-
公开(公告)号：EP2831272B8
公开(公告)日：2018-11-21
申请号：EP13715106.4
申请日：2013-03-27
IPC分类号： C12Q1/6883 , C12N15/10
CPC分类号： G06F19/18 , C12N15/1072 , C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5044 , G06F19/20
摘要： A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent. The system also includes a programmable computer with computer-readable instructions that allow the computer to accessing the instances and a hyperpigmentation-relevant gene expression signature stored on the computer readable medium, comparing the hyperpigmentation-relevant gene expression signature to the plurality of the instances, and/or assigning a connectivity score to each of the plurality of instances.
-
公开(公告)号：EP2183693B2
公开(公告)日：2018-11-14
申请号：EP08776043.5
申请日：2008-07-23
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6888 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , G01N2800/387 , G06F19/18 , G06F19/22 , Y02A90/26 , C12Q2521/331 , C12Q2537/16
摘要： Embodiments of this invention provide methods, systems and apparatus for determining whether a cancer exists from a biological sample. Nucleic acid molecules of the biological sample are randomly sequenced and respective amounts of a clinically relevant chromosome and background chromosomes are determined from the results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a cancer exists.
-
公开(公告)号：EP3374907A1
公开(公告)日：2018-09-19
申请号：EP16864761.8
申请日：2016-10-25
申请人： Dow Agrosciences LLC
CPC分类号： C12Q1/6876 , C12Q1/6895 , C12Q2600/154 , C12Q2600/158 , G06F19/18 , G06F19/20
摘要： The present invention is based on the use of the H3K9me2 methylation levels in plant genomes to predict transgene silencing, transgene stability, and/or transgene expression level. Provided are methods and/or systems for generating whole-genome H3K9me2 maps and its use with an assigned threshold value for predicting gene silencing. The methods and/or systems provided herein can be used in high-throughput setting for screening large number of transformed event in a relatively short period of time as compared to existing technologies.
-
公开(公告)号：EP3374903A1
公开(公告)日：2018-09-19
申请号：EP16865208.9
申请日：2016-11-14
申请人： Williams, Samuel
发明人： Williams, Samuel
摘要： The disclosure described herein can be used for very rapid real-time acquisition of short DNA reads that can be used for time-sensitive aneuploidy detection in prenatal and IVF care as well as sequencing of small DNA fragments and amplicons in the field or clinic. This ability can expand the utility of nanopore-based sequencing methods for clinical and research applications.
-
公开(公告)号：EP2977466B1
公开(公告)日：2018-09-19
申请号：EP15175962.8
申请日：2015-07-08
申请人： Yourgene Bioscience
发明人： Chan, Chia-Han
CPC分类号： G06F19/22 , C12Q1/6827 , C12Q2600/112 , G06F19/18 , C12Q2535/122
摘要： A method for detecting a chromosomal aneuploidy relating to a target nucleic acid region includes the following steps. A reference database is obtained. At least one normalizing factor is determined based on the reference database. A cutoff value is determined based on the reference database. A biological sample under test is sequenced by the sequencing platform to obtain a number of target reads of the biological sample under test. The target reads of the biological sample under test originate from the target nucleic acid region. The number of the target reads of the biological sample under test is normalized by the normalizing factor and then is compared with the cutoff value. Whether the chromosomal aneuploidy relating to the target nucleic acid region is present in the fetus is determined based on the comparison.
-
公开(公告)号：EP3373012A1
公开(公告)日：2018-09-12
申请号：EP17305242.4
申请日：2017-03-07
发明人： POYNARD, Thierry
CPC分类号： G01N33/6893 , G01N2800/085 , G06F19/18 , G06F19/24
摘要： The present invention relates to new methods for assessing prognosis of recovery of DILI in a patient, combining measurement of serum markers through a logistic function that doesn't include bilirubin and AST markers.
-
公开(公告)号：EP3372690A1
公开(公告)日：2018-09-12
申请号：EP16861627.4
申请日：2016-11-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/68 , C12Q1/6809 , C12Q1/6811 , C12Q1/686 , C12Q1/6883 , G06F19/18 , G06F19/22 , G16H50/20
摘要： Provided is a method of detecting a chromosome abnormality in an embryo by using blastocyst culture. The method comprises: detecting embryonic circulating cell-free DNA in early embryonic in-vitro culture, i.e., blastocyst culture, performing uniform whole genome amplification on trace DNA, and then using a method, such as next generation sequencing, to perform analysis on the amplified DNA product, so as to determine a chromosome condition of an embryo, namely, whether aneuploidy or partial aneuploidy of chormosomes occurs.
-
公开(公告)号：EP3369023A1
公开(公告)日：2018-09-05
申请号：EP16788669.6
申请日：2016-10-27
CPC分类号： G06F19/706 , G06F19/16 , G06F19/18
摘要： A method of designing a D-polypeptide that binds with an L-target protein can include: identifying a polypeptide target having L-chirality; determining hotspot amino acids of a polypeptide ligand having L-chirality that have binding interactions with the L-target protein; determining transformations of side chains of the hotspot amino acids that retain the binding interactions with the target; generating inversed hotspot amino acids with chirality opposite to the one of the target; identifying a polypeptide having inverse chirality from the target protein, on which a combination of inversed hotspot amino-acid can be grafted without significantly changing their interactions with the target. The designed ligands can be processed and converted to D-ligands that bind with the L-target protein.
-
公开(公告)号：EP2944957B1
公开(公告)日：2018-08-22
申请号：EP15163430.0
申请日：2004-12-15
发明人： Ostrander, Elaine , Kruglyak, Leonid , Parker, Heidi G. , Kim, Lisa V. , Stephens, Matthew , Malek, Tiffany B. , Sutter, Nathan B. , Carlson, Scott
IPC分类号： C12Q1/6888 , G06F19/18
CPC分类号： C12Q1/6888 , C12Q2600/156 , G06F19/18
摘要： In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
-
-
-
-
-
-
-
-
-
搜索结果
2070 条记录 (耗时 0.022 秒)
