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1.发明公开BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 有权生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：EP2606139A2
公开(公告)日：2013-06-26
申请号：EP11818555.2
申请日：2011-08-08
申请人： Codexis, Inc. , Cabirol, Fabien L. , Gohel, Anupam , Collier, Steven J. , Liang, Jack , Mock, Marissa , Mundorff, Emily , Novick, Scott , Limanto, John , Smith, Derek , Beutner, Gregory , Klapars, Artis , Ashley, Eric , Strotman, Hallena , Truppo, Matthew , Hughes, Gregory , Grau, Brendan , Janey, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
CPC分类号： C12P13/001 , C12N9/1096
摘要： The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
摘要翻译： 本公开提供了能够以至少2:1非对映异构体将底物2-（3,4-二甲氧基苯乙氧基）环己酮转化成反式非对映异构体产物（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的转氨酶多肽 相对于顺式非对映异构体（1R，2S）-2-（3,4-二甲氧基苯乙氧基）环己胺的比例。 本公开还提供了用于制备（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺及其类似物的方法中制备和使用转氨酶多肽的多核苷酸，载体，宿主细胞和方法， 进一步用于制备作为离子通道阻断剂的氨基环己基醚化合物（3R）-1 - [（1R，2R）-2- [2-（3,4-二甲氧基苯基）乙氧基]环己基]吡咯烷-3-醇。
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2.发明授权BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 有权生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯氧基）环己胺合成方法
公开(公告)号：EP2606139B1
公开(公告)日：2015-07-15
申请号：EP11818555.2
申请日：2011-08-08
申请人： Codexis, Inc. , Cabirol, Fabien L. , Gohel, Anupam , Collier, Steven J. , Liang, Jack , Mock, Marissa , Mundorff, Emily , Novick, Scott , Limanto, John , Smith, Derek , Beutner, Gregory , Klapars, Artis , Ashley, Eric , Strotman, Hallena , Truppo, Matthew , Hughes, Gregory , Grau, Brendan , Janey, Jacob
发明人： CABIROL, Fabien, L. , GOHEL, Anupam , COLLIER, Steven, J. , LIANG, Jack , MOCK, Marissa , MUNDORFF, Emily , NOVICK, Scott , LIMANTO, John , SMITH, Derek , BEUTNER, Gregory , KLAPARS, Artis , ASHLEY, Eric , STROTMAN, Hallena , TRUPPO, Matthew , HUGHES, Gregory , GRAU, Brendan , JANEY, Jacob
CPC分类号： C12P13/001 , C12N9/1096
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3.发明公开BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE 有权生物催化剂和（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺合成方法
公开(公告)号：EP2606139A4
公开(公告)日：2014-03-26
申请号：EP11818555
申请日：2011-08-08
申请人： CODEXIS INC , CABIROL FABIEN L , GOHEL ANUPAM , COLLIER STEVEN J , LIANG JACK , MOCK MARISSA , MUNDORFF EMILY , NOVICK SCOTT , LIMANTO JOHN , SMITH DEREK , BEUTNER GREGORY , KLAPARS ARTIS , ASHLEY ERIC , STROTMAN HALLENA , TRUPPO MATTHEW , HUGHES GREGORY , GRAU BRENDAN , JANEY JACOB
发明人： CABIROL FABIEN L , GOHEL ANUPAM , COLLIER STEVEN J , LIANG JACK , MOCK MARISSA , MUNDORFF EMILY , NOVICK SCOTT , LIMANTO JOHN , SMITH DEREK , BEUTNER GREGORY , KLAPARS ARTIS , ASHLEY ERIC , STROTMAN HALLENA , TRUPPO MATTHEW , HUGHES GREGORY , GRAU BRENDAN , JANEY JACOB
CPC分类号： C12P13/001 , C12N9/1096
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