公开(公告)号：EP4405326A1

公开(公告)日：2024-07-31

申请号：EP22793384.3

申请日：2022-09-19

申请人： Covestro Deutschland AG ,  Genomatica, Inc.

发明人： MERKEL, Michael

IPC分类号： C07C209/84 ,  C07C211/12 ,  C07C211/09 ,  C07C263/10 ,  C07C265/14 ,  C12P13/00 ,  C08G18/00

CPC分类号： C07C209/84 ,  C07C263/10 ,  C07C209/00 ,  C07C211/09 ,  C07C211/12 ,  C07C265/14 ,  C12P13/001

公开(公告)号：EP4402276A1

公开(公告)日：2024-07-24

申请号：EP22777346.2

申请日：2022-09-14

申请人： Richter Gedeon Nyrt. ,  Budapesti Müszaki és Gazdaságtudományi Egyetem

发明人： FARKAS, Emese ,  POPPE, László ,  HORNYÁNSZKY, Gábor ,  INCZE, Dániel János ,  ÉLES, János ,  SÁNTA-BELL, Evelin ,  MOLNÁR, Zsófia Klára ,  SZEMES, József ,  SCHNEIDER, Anna ,  CSUKA, Pál

IPC分类号： C12P13/00 ,  C12P17/02 ,  C12P41/00 ,  C07C219/24 ,  C07C223/04 ,  C07C227/34 ,  C07C229/28

CPC分类号： C07C209/88 ,  C07C213/10 ,  C07C227/34 ,  C12P13/001 ,  C12P13/005 ,  C12P17/02 ,  C12P41/006

公开(公告)号：EP1988170B1

公开(公告)日：2019-05-01

申请号：EP07714383.2

申请日：2007-02-16

申请人： TORAY INDUSTRIES, INC.

发明人： SAWAI, Hideki ,  YAMADA, Katsushige ,  MIMITSUKA, Takashi ,  SAWAI, Kenji ,  YONEHARA, Tetsu ,  ITO, Yohito ,  HENMI, Masahiro

IPC分类号： C12P13/04 ,  C12M1/34 ,  C12M1/00 ,  C12P7/06 ,  C12P7/18 ,  C12P7/46 ,  C12P7/50 ,  C12P7/56 ,  C12P13/08 ,  C12P19/30 ,  C12P13/00

CPC分类号： C12P7/06 ,  C12M29/04 ,  C12M29/18 ,  C12M41/40 ,  C12M47/10 ,  C12P7/18 ,  C12P7/46 ,  C12P7/50 ,  C12P7/56 ,  C12P13/001 ,  C12P13/005 ,  C12P13/04 ,  C12P13/08 ,  C12P19/30 ,  Y02E50/17

摘要： The invention provides a method of producing a chemical product through continuous fermentation which includes filtering a culture of a microorganism or cultured cells with a separation membrane to recover a product from a filtrate and simultaneously retaining a nonfiltered fluid in, or refluxing it to, the culture, and adding fermentation materials to the culture, wherein a porous membrane having an average pore size of 0.01 µm or more to less than 1 µm is used as the separation membrane and the filtration is conducted with a transmembrane pressure difference in the range of 0.1 to 20 kPa. According to this method, the fermentation productivity of the chemical product can be largely elevated at high stability and a low cost.

公开(公告)号：EP3118312B1

公开(公告)日：2018-12-26

申请号：EP15761936.2

申请日：2015-03-11

申请人： Ajinomoto Co., Inc.

发明人： OONISHI, Fumito ,  MIHARA, Yasuhiro

IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/88 ,  C12P13/00

CPC分类号： C12N9/88 ,  C12P13/001 ,  C12Q1/6876 ,  C12Y401/01018

摘要： The present invention provides methods and means of producing 1,5-PD efficiently in a manner suitable for an actual production. Specifically, the present invention provides a method of producing 1,5-pentamethylenediamine comprising forming 1,5-pentamethylenediamine from L-lysine and/or a salt thereof by an action of a mutated lysine decarboxylase having mutation(s) of one or more amino acid residues that improve a thermal stability in any amino acid sequence of (a) the amino acid sequence of SEQ ID NO:1, (b) an amino acid sequence comprising one or several amino acid residue substitutions, deletions, insertions or additions in the amino acid sequence of SEQ ID NO:1, or (c) an amino acid sequence having 90% or more identity to the amino acid sequence of SEQ ID NO:1, and having a lysine decarboxylation activity; and the like.

公开(公告)号：EP3406594A1

公开(公告)日：2018-11-28

申请号：EP18163465.0

申请日：2013-12-03

申请人： MERCK SHARP & DOHME CORP.

发明人： Bulger, Paul Gerard ,  Kosjek, Birgit ,  Rivera, Nelo

IPC分类号： C07D211/02

CPC分类号： C12P17/12 ,  C07D211/02 ,  C12N9/1096 ,  C12P13/001 ,  C12Y206/01

摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I :

employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.

公开(公告)号：EP2970097B1

公开(公告)日：2018-10-31

申请号：EP14770640.2

申请日：2014-03-14

申请人： Vistagen Therapeutics, Inc.

发明人： ABELE, Stefan ,  LAUE, Klaus ,  BREITENMOSER, Roland, A.

IPC分类号： C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C233/47 ,  C12P13/04

CPC分类号： C12P13/001 ,  C07C221/00 ,  C07C227/04 ,  C07C229/36 ,  C07C231/12 ,  C12P13/04 ,  C12Y305/01014 ,  C07C225/22 ,  C07C233/47

摘要： Provided are methods for synthesizing compounds, including chiral kynurenine compounds. The methods are suitable for large-scale manufacture and produce the chiral kynurenines compounds in high chemical purity and high chiral purity.

公开(公告)号：EP2650374B1

公开(公告)日：2018-05-30

申请号：EP11846664.8

申请日：2011-12-08

申请人： Toray Industries, Inc.

发明人： SASAKI, Nanami ,  MIMITSUKA, Takashi ,  SAWAI, Hideki ,  SAWAI, Kenji

IPC分类号： C12P13/00 ,  C12N15/09

CPC分类号： C12P13/001 ,  C12Y401/01018

摘要： Disclosed is a novel method for producing cadaverine, which method is capable of producing cadaverine more efficiently and at a higher yield than production methods by the conventional fermentation methods. The method for producing cadaverine includes culturing coryneform bacterium/bacteria having an ability to produce cadaverine and having a resistance to 2,2'-thiobis(ethylamine). Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity, and preferably, the coryneform bacterium/bacteria has/have homoserine auxotrophy and/or a resistance to S-(2-aminoethyl)-L-cysteine.

公开(公告)号：EP2806022B1

公开(公告)日：2018-05-23

申请号：EP13738280.0

申请日：2013-01-21

申请人： Cj Cheiljedang Corporation

发明人： LEE, Kyoung Min ,  KIM, Seon Hye ,  UM, Hye Won ,  KANG, Min Sun ,  CHOI, Su Jin ,  JUNG, Hee Kyoung ,  JHON, Sung Hoo ,  LI, Hongxian ,  GWAK, Won Sik ,  LEE, Chong Ho ,  YANG, Young Lyeol

IPC分类号： C12N1/21 ,  C12N15/60 ,  C12N15/74 ,  C12P13/00

CPC分类号： C12N15/77 ,  C12N15/52 ,  C12P13/001

摘要： The present invention relates to a recombinant microorganism having enhanced ability to produce putrescine at high yield, wherein the activity of NCgl0101 is weakened in a microorganism of genus Corynebacterium that has been modified to produce putrescine, and a method for producing putrescine using the same.

公开(公告)号：EP3224354A4

公开(公告)日：2018-05-16

申请号：EP15864252

申请日：2015-11-24

申请人： CODEXIS INC

发明人： ALVIZO OSCAR ,  MAYO MELISSA ANN ,  MOORE JEFFREY C

IPC分类号： C12N9/08

CPC分类号： C12N9/0028 ,  C07K14/195 ,  C12P13/001

摘要： The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：EP2836592B1

公开(公告)日：2018-05-16

申请号：EP13709422.3

申请日：2013-03-13

申请人： Evonik Degussa GmbH

发明人： SCHAFFER, Steffen ,  FARWICK, Mike ,  ANDREA, Heiko ,  KÖHLER, Tim ,  WOLFF, Daniel ,  TER VELD, Frank ,  POETSCH, Ansgar ,  BOLES, Eckhard ,  SCHORSCH, Christoph

IPC分类号： C12N9/12

CPC分类号： C12P13/02 ,  C12N9/1025 ,  C12N9/1029 ,  C12P13/001