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公开(公告)号：EP2666786A1
公开(公告)日：2013-11-27
申请号：EP12003960.7
申请日：2012-05-21
申请人： PAION Deutschland GmbH , Inserm
IPC分类号： C07K16/28
CPC分类号： C07K16/286 , A61K2039/505
摘要： A binding protein for the treatment of intracranial hemorrhage, wherein the binding protein is capable of binding to the N-terminal domain of the NMDA receptor subunit NR1 (ATD NR1) thereby preventing the t-PA induced proteolysis of the NR1 subunit.
摘要翻译： 用于治疗颅内出血的结合蛋白，其中结合蛋白能够结合NMDA受体亚基NR1（ATD NR1）的N末端结构域，从而防止t-PA诱导NR1亚基的蛋白水解。
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公开(公告)号：EP2440237A1
公开(公告)日：2012-04-18
申请号：EP09776712.3
申请日：2009-06-12
CPC分类号： C12Q1/56 , A61K38/366 , C07K14/7455 , C12Q2521/537 , G01N33/86
摘要： The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
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3.发明授权Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen 有权Nicht-neurotoxische纤溶酶原Aktivierende Faktoren zur Behandlung vonSchlaganfällen
公开(公告)号：EP1308166B1
公开(公告)日：2009-08-26
申请号：EP01130006.8
申请日：2001-12-17
CPC分类号： C12N9/6459 , A61K31/7068 , A61K38/49 , A61K45/06 , C12Y304/21068 , C12Y304/21069
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4.发明公开Novel strategies for increasing the reperfusion in obstructed blood vessel 审中-公开Neuartige Strategien zurErhöhungder Reperfusion in einem verstopftenBlutgefäß
公开(公告)号：EP2014296A1
公开(公告)日：2009-01-14
申请号：EP07013480.4
申请日：2007-07-10
CPC分类号： C07K14/7455 , A61K38/366
摘要： Use of thrombomodulin for the manufacture of a medicament for stimulating the reperfusion of an ischemic tissue or organ within a patient in the need thereof, in particular a stroke patient.
摘要翻译： 血栓调节蛋白用于制造药物的用途，所述药物用于刺激患者需要的缺血组织或器官的再灌注，特别是中风患者。
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5.发明公开
公开(公告)号：EP1897554A1
公开(公告)日：2008-03-12
申请号：EP06017750.8
申请日：2006-08-25
发明人： Thiex, Ruth , Rohde, Veith , Petersen, Karl-Uwe
CPC分类号： A61K38/49
摘要： Use of a plasminogen activator for the manufacture of a medicament for the treatment of hemorrhagic stroke, wherein the plasminogen activator does not substantially activate the NMDA type glutamate receptor within the patient.
摘要翻译： 纤溶酶原激活剂为出血性中风治疗的药物中的用途，worin所述纤溶酶原激活剂基本上不使用激活患者内的NMDA型谷氨酸受体。
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6.发明公开
公开(公告)号：EP1863910A1
公开(公告)日：2007-12-12
申请号：EP05787488.5
申请日：2005-09-06
发明人： PAN, Junliang , WU, Qingyu , SCHÜTTLER, Achim
CPC分类号： C12N9/6456 , A61K38/00 , A61K47/6849 , C07K2319/33
摘要： This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen activator DSPAalphal, or analogs, fragments, derivatives, or variants thereof, which are useful as thrombolytic agents. Pharmaceutical compositions containing these fusion proteins, methods of using these fusion proteins as thrombolytic agents, and processes for synthesizing these fusion proteins are also described herein.
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公开(公告)号：EP2579890A1
公开(公告)日：2013-04-17
申请号：EP10805599.7
申请日：2010-12-15
IPC分类号： A61K38/36 , C12Q1/00 , A61P7/04 , C07K14/745
CPC分类号： C07K14/7455 , A61K38/00 , G01N33/573
摘要： The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
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8.发明授权
公开(公告)号：EP1997510B1
公开(公告)日：2012-02-29
申请号：EP08012976.0
申请日：2002-10-31
CPC分类号： C12N9/6459 , A61K31/7068 , A61K38/49 , A61K45/06 , C12Y304/21068 , C12Y304/21069
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公开(公告)号：EP2211898A2
公开(公告)日：2010-08-04
申请号：EP08838897.0
申请日：2008-10-20
CPC分类号： A61K38/482 , A61K38/49
摘要： A method for treating a stroke patient with thrombolysis, whereas prior treatment the patient is diagnosed in particular for exhibiting cerebral tissue at risk, a cerebral artery occlusion and/or an absolute 'mismatch volume'.
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公开(公告)号：EP2050462A1
公开(公告)日：2009-04-22
申请号：EP07020401.1
申请日：2007-10-18
CPC分类号： A61K38/49
摘要： A method for treating a stroke patient with thrombolysis, whereas prior treatment the patient is diagnosed for exhibiting cerebral tissue at risk and a cerebral artery occlusion.
摘要翻译： 用于治疗溶栓的中风患者的方法，而在之前的治疗中，诊断患者显示出有风险的脑组织和大脑动脉闭塞。
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