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公开(公告)号：EP2406399B1
公开(公告)日：2018-02-14
申请号：EP10751262.6
申请日：2010-03-09
申请人： Bioatla, LLC
CPC分类号： C12N15/102 , A61K38/00 , C07K7/06 , C07K14/3153 , C07K14/47 , C07K14/575 , C07K14/57545 , C07K14/57563 , C12N9/16 , C12N9/50 , C12N9/6435 , C12N9/6459 , C12N9/6462 , C12N15/1058 , C12Y302/01035 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073 , C12Y304/23015 , C12Y304/24029 , G01N33/54306 , G01N33/573 , G01N33/6845 , G01N33/6854 , Y02A50/473
摘要： A method of generating conditionally active biologic antibodies from parent antibodies, in particular therapeutic antibodies, which are more active at an aberrant physiological condition than at a normal physiological condition and which may reversibly or irreversibly inactivated at the wild type normal physiological condition. For example, evolved antibodies are may be less active or inactive at normal body temperature or pH, than at other aberrant body temperatures or at an aberrant pH.
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公开(公告)号：EP2928480A4
公开(公告)日：2016-07-06
申请号：EP13859652
申请日：2013-12-05
申请人： NAT JEWISH HEALTH
发明人： WHITE CARL W , VERESS LIVIA A
CPC分类号： C12N9/6459 , A61K9/0078 , A61K38/482 , A61K38/49 , C12N9/6462 , C12Y304/21068 , C12Y304/21073
摘要： The present invention is directed to methods of treatment of airway obstruction associated with fibrin-containing cast formation by administering a fibrinolytic agent.
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公开(公告)号：EP2279753B1
公开(公告)日：2015-09-16
申请号：EP10012536.8
申请日：2002-10-09
申请人： Novo Nordisk A/S
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodelling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group of peptide.
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公开(公告)号：EP2279754B1
公开(公告)日：2014-08-13
申请号：EP10012938.6
申请日：2002-10-09
申请人： ratiopharm GmbH
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodelling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group of peptide.
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公开(公告)号：EP2305313B1
公开(公告)日：2014-03-26
申请号：EP10012797.6
申请日：2002-10-09
申请人： ratiopharm GmbH
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/2445 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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公开(公告)号：EP2298354B1
公开(公告)日：2014-03-19
申请号：EP10012796.8
申请日：2002-10-09
申请人： ratiopharm GmbH
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/2445 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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7.发明公开
公开(公告)号：EP2600891A4
公开(公告)日：2014-01-01
申请号：EP11814173
申请日：2011-08-05
发明人： MAHESHWARI NEERAJ , SAHNI GIRISH
CPC分类号： C12N9/48 , A61K38/00 , A61K38/166 , A61K38/1709 , C07K14/3153 , C07K14/7455 , C07K2319/00 , C12N9/52 , C12N9/6459 , C12Y304/21069
摘要： The present invention discloses novel hybrid proteins that have both plasminogen activator and anti-thrombotic properties, including clot specific action, that renders these as highly advantageous for the treatment of circulatory disorders involving fibrin clot formation due to underlying tissue damage in the blood vessels leading to myocardial infarction, strokes etc. Also disclosed are new proteins, and methods of obtaining the same, that help to dissolve blood clots by activating plasminogen in a plasmin or thrombin dependent manner and also inhibit both the activity and generation of thrombin through the intrinsic pathway of blood coagulation.
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公开(公告)号：EP2305314A3
公开(公告)日：2011-09-14
申请号：EP10012798.4
申请日：2002-10-09
申请人： BioGeneriX AG
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/2445 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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公开(公告)号：EP2279754A3
公开(公告)日：2011-06-22
申请号：EP10012938.6
申请日：2002-10-09
申请人： BioGeneriX AG
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
摘要翻译： 本发明包括用于重构肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或将修饰基团添加至肽。
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10.发明公开Methods for detecting and clearing cross beta structure comprising proteins with crossbeta structure binding compounds. 审中-公开一种用于容纳具有交叉的β结构结合化合物蛋白质发生交叉的β结构的检测和校正方法。
公开(公告)号：EP2322154A2
公开(公告)日：2011-05-18
申请号：EP10185187.1
申请日：2003-07-08
发明人： Gebbink, Martijn Frans Ben Gerard , Bouma, Barend , Kranenburg, Onno Wouter , Kroon, Louise Maria Johanna
IPC分类号： A61K31/00 , A61K31/7004 , A61K31/195 , A61K31/197 , A61K31/198 , A61K39/395 , A61K38/49 , G01N33/53 , C12N9/72 , A61P9/10 , A61P3/10 , A61P7/04 , A61P35/00 , A61P31/00 , A61P37/00 , A61P25/28 , A61P25/16 , A61M1/36 , A61P7/02 , A61P29/00 , A61P25/08 , G01N33/68 , A61M1/16 , A61M1/14
CPC分类号： A61K31/7004 , A61K31/00 , A61K31/195 , A61K31/197 , A61K31/198 , A61K38/49 , C07K16/18 , C07K2319/23 , C12N9/6459 , C12Y304/21069 , G01N33/6854 , G01N33/6896 , G01N2333/9726 , G01N2800/042 , G01N2800/2821
摘要： The invention relates to the fields of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to crossbeta structure binding compounds coupled to a solid surface.
摘要翻译： 本发明涉及生物化学，分子生物学，结构生物学和医学领域。 更特别地，本发明涉及交叉连接到固体表面上的β结构结合化合物。
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