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公开(公告)号：EP0577675A1
公开(公告)日：1994-01-12
申请号：EP92907484.0
申请日：1992-03-27
发明人： ALMEN, Torsten , BERG, Arne , CHANG, C. Allen , DROEGE, Michael , DUGSTAD, Harald , FELLMAN, Jere D. , KIM, Sook-Hui , KLAVENESS, Jo , ROCKLAGE, Scott M. , RONGVED, Pal , SEGAL, Brent , WATSON, Alan D.
CPC分类号： C07F11/005 , A61K49/06 , C07F15/025 , Y10S514/836 , Y10S977/903 , Y10S977/928 , Y10S977/929
摘要： Milieux de contraste pour imagerie comportant un complexe polynucléaire tolérable physiologiquement (tel que défini dans la revendication 1). Ledit complexe polynucléaire contient au moins deux, et de préférence trois, atomes augmentant le contraste. Dans les techniques d'imagerie par rayons X ou par ultrasons, on utilise des atomes de métaux lourds pour augmenter le contraste, tandis qu'en imagerie par résonance magnétique les atomes de métaux paramagnétiques servent à augmenter le contraste. Les atomes d'augmentation de contraste préférés sont le molybdène et le tungstène. On peut également utiliser le milieu en thérapeutique.
摘要翻译： 包含生理学可耐受的多核复合物（如权利要求1所定义）的成像造影剂。 多核配合物含有至少两个，优选三个对比增强原子。 在X射线或超声成像技术中，重金属原子用于增加对比度，而在磁共振成像中，顺磁金属原子用于增加对比度。 优选的对比增强原子是钼和钨。 该介质也可以用于治疗。
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公开(公告)号：EP0755269B1
公开(公告)日：2005-12-07
申请号：EP95915940.1
申请日：1995-04-20
发明人： MARGERUM, Larry , CAMPION, Brian , FELLMANN, Jere, Douglas , GARRITY, Martha , VARADARAJAN, John
CPC分类号： A61K49/124 , A61K47/60 , A61K49/085 , A61K49/106 , A61K49/1812 , A61K51/065 , A61K2121/00 , A61K2123/00 , C08G79/00
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公开(公告)号：EP0556240B1
公开(公告)日：1996-07-10
申请号：EP91919479.5
申请日：1991-11-06
IPC分类号： C07D259/00 , A61K49/00
CPC分类号： A61K49/06 , A61K49/0002 , C07D259/00
摘要： The present invention relates to macrocyclic chelating agents, optionally possessing more than one macrocyclic ring but typically characterised by their possession of at least two peptide linkages within the macrocyclic skeleton. These chelating agents may be used for example for the preparation of paramagnetic metal chelates for use as MRI contrast agents.
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公开(公告)号：EP0474642B1
公开(公告)日：1996-06-26
申请号：EP90906169.9
申请日：1990-04-05
CPC分类号： A61K49/143 , A61K47/645 , A61K49/085 , A61K49/12 , A61K49/128 , A61K49/146 , A61K49/16 , A61K51/065 , A61K51/081 , A61K51/088 , C08G69/48
摘要： There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a polyamine backbone molecule, e.g. polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.
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公开(公告)号：EP0625055A1
公开(公告)日：1994-11-23
申请号：EP93904187.0
申请日：1993-02-11
发明人： WATSON, Alan, D. , KLAVENESS, Jo , JAMIESON, Gene, C. , FELLMANN, Jere, Douglas , VOGT, Nils, Blane , COCKBAIN, Julian, R., M.
IPC分类号： G01N23 , A61B5 , A61K9 , A61K31 , A61K33 , A61K41 , A61K45 , A61K47 , A61K49 , A61K51 , G01R33
CPC分类号： A61K51/1268 , A61K41/0057 , A61K41/0095 , A61K49/0084 , A61K49/0438 , A61K49/085 , A61K49/189 , A61K49/228 , A61K2123/00 , B82Y5/00 , Y10S977/927
摘要： Composés comprenant des mailles moléculaires étroites, de préférence incurvées dans un ou deux sens, tels que des fullerènes ou des métallocarbohéchanes et pouvant s'utiliser en tant qu'agents diagnostiques ou thérapeutiques ou en tant que véhicules de ceux-ci, particulièrement des agents de contraste d'imagerie diagnostique.
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公开(公告)号：EP0463644A2
公开(公告)日：1992-01-02
申请号：EP91116072.9
申请日：1987-07-25
发明人： Kraft, Karl F., c/o Salutar Inc. , Quay, Steven Carl, c/o Salutar Inc. , Rocklage, Scott M. , Worah, Dilip M.
CPC分类号： G01R33/5601 , A61K49/06 , C07D259/00 , C07F5/003 , C07F9/3817 , C07F13/005
摘要： The disclosure provides the use of a physiologically compatible chelate complex of a chelating compound and a paramagnetic ion of a lanthanide element having an atomic number in the range 57 to 70 or of a transition metal having an atomic number selected from 21 to 29, 42 and 44 and of a non-paramagnetic organic calcium salt for the preparation of a magnetic resonance imaging contrast medium by admixture of said complex and said organic salt. The admixed calcium serves to enhance the biotolerability of the paramagnetic chelate containing MRI contrast medium.
摘要翻译： 本发明提供螯合化合物和原子序数在57至70范围内的镧系元素的顺磁性离子或具有选自21至29,42的原子序数的过渡金属的生理上相容的螯合络合物和 44和非顺磁性有机钙盐，用于通过所述配合物和所述有机盐的混合来制备磁共振成像造影剂。 混合的钙用于增强含有MRI造影剂的顺磁性螯合物的生物适应性。
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7.发明授权DIAMIDE-DTPA-PARAMAGNETIC CONTRAST AGENTS FOR MR IMAGING, APPARATUS AND METHODS 失效用于磁共振成像的DIAMIDE-DTPA-PARAMAGNETIC对比剂，装置和方法
公开(公告)号：EP0203962B1
公开(公告)日：1991-05-02
申请号：EP85905998.2
申请日：1985-11-12
申请人： SALUTAR, INC.
发明人： QUAY, Steven, G.
CPC分类号： G01R33/5601 , A61K49/06 , Y10S436/806 , Y10T436/24
摘要： Homologs of Diamide-DTPA-Paramagnetic compounds (such as diamido acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by the unpaired electron within the paramagnetic (PM) atom, causes a local reduction in the bulk magnetic field of the MR system. The resulting shortening of the T1 (spin lattice) relaxation time in the local hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The tissue or organ of interest appears on the MR display highlighted in white. Background tissue is displayed as darker or lower intensity greys. A surface highlighted image of the small and large intestine may be obtained by venous injection of the diamide contrast agent. The contrast agent is formed by replacing two carboxylic acids on the DTPA chelator with functional amide groups. The homologs enable the Diamide-DTPA-PM contrast agents to go into solution readily, and promote organ selectivity.
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公开(公告)号：EP0785804B1
公开(公告)日：2004-06-23
申请号：EP95933505.0
申请日：1995-10-09
CPC分类号： A61K49/1812 , A61K51/1234
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公开(公告)号：EP0748229B1
公开(公告)日：2002-09-04
申请号：EP95910609.7
申请日：1995-03-03
IPC分类号： A61K51/00 , A61K49/00 , C08G83/00 , C07D259/00
CPC分类号： A61K49/124 , A61K49/085 , A61K49/12 , A61K51/065 , C07D259/00 , C08G83/00 , Y10S424/16
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公开(公告)号：EP0785804A1
公开(公告)日：1997-07-30
申请号：EP95933505.0
申请日：1995-10-09
CPC分类号： A61K49/1812 , A61K51/1234
摘要： There is provided a liposomal agent comprising liposomes having bound to a membrane thereof a chelated diagnostically or therapeutically effective metal ion, the chelating agent binding said metal ion having a macrocyclic chelant moiety with attached to a single ring atom thereof a lipophilic membrane associating moiety.
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