公开(公告)号：EP1385556A1

公开(公告)日：2004-02-04

申请号：EP02725889.6

申请日：2002-04-30

申请人： University of Missouri System at Columbia ,  Hoffman, Timothy J. ,  Volkert, Wynn A. ,  Sieckman, Gary ,  Higginbotham, Chrys-Ann ,  Li, Ning

发明人： HOFFMAN, Timothy, J. ,  VOLKERT, Wynn, A. ,  SIECKMAN, Gary ,  HIGGINBOTHAM, Chrys-Ann ,  LI, Ning ,  GALI, Hariprasad ,  SMITH, Charles, J.

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K51/088

摘要： A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

公开(公告)号：EP1385556A4

公开(公告)日：2005-10-19

申请号：EP02725889

申请日：2002-04-30

申请人： UNIV MISSOURI SYSTEM AT COLUMB ,  HOFFMAN TIMOTHY J ,  VOLKERT WYNN A ,  SIECKMAN GARY ,  HIGGINBOTHAM CHRYS ANN ,  LI NING

发明人： HOFFMAN TIMOTHY J ,  VOLKERT WYNN A ,  SIECKMAN GARY ,  HIGGINBOTHAM CHRYS-ANN ,  LI NING ,  GALI HARIPRASAD ,  SMITH CHARLES J

IPC分类号： A61K51/08 ,  A61K51/00 ,  A61M36/14

CPC分类号： A61K51/088