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1.发明公开
公开(公告)号：EP1677775A2
公开(公告)日：2006-07-12
申请号：EP04810055.6
申请日：2004-10-27
IPC分类号： A61K31/095 , A61K31/198 , A61P17/00
CPC分类号： A61K31/198 , A61K31/095 , A61K41/00 , A61K2300/00
摘要： Methods of preventing or reducing mucositis in patients who have been exposed to toxic levels of radiation or who are undergoing treatment with platinum-containing anti-tumor compounds are provided. The methods comprise administering an effective amount of a protective agent comprising methionine or a methionine-like moiety to said patient prior to, simultaneously with, or subsequently to exposure to radiation or administration of a platinum-containing anti-tumor compound. Combinations of these time periods can also be employed.
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2.发明授权
公开(公告)号：EP1677775B1
公开(公告)日：2011-12-07
申请号：EP04810055.6
申请日：2004-10-27
IPC分类号： A61K31/095 , A61K31/198 , A61P17/00
CPC分类号： A61K31/198 , A61K31/095 , A61K41/00 , A61K2300/00
摘要： Methods of preventing or reducing mucositis in patients who have been exposed to toxic levels of radiation or who are undergoing treatment with platinum-containing anti-tumor compounds are provided. The methods comprise administering an effective amount of a protective agent comprising methionine or a methionine-like moiety to said patient prior to, simultaneously with, or subsequently to exposure to radiation or administration of a platinum-containing anti-tumor compound. Combinations of these time periods can also be employed.
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公开(公告)号：EP3170189A1
公开(公告)日：2017-05-24
申请号：EP15822160.6
申请日：2015-07-17
申请人： Board of Supervisors, Louisiana State University and Agricultural College , THE BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
发明人： STADLER, Shane , ALI, Naushad , SAMANTA, Tapas
CPC分类号： C22C30/00 , C22C19/005 , C22C22/00 , H01F1/015
摘要： A multicaloric alloy material combines two isostructural compounds, the first compound being MnNiSi and the second compound being either MnFeGe or CoFeGe, each such compound having extremely different magnetic and thermo-structural properties. The resulting alloy material (MnNiSi)1-x(MnFeGe)x or (MnNiSi)1-x(CoFeGe)x possesses extraordinary magnetocaloric and/or barocaloric properties with an acute sensitivity to applied pressure and no appreciable magnetic hysteresis losses.
摘要翻译： 多元合金材料结合了两种同构化合物，第一种化合物是MnNiSi，第二种化合物是MnFeGe或CoFeGe，每种这种化合物具有极其不同的磁性和热结构性质。 所得到的合金材料（MnNiSi）1-x（MnFeGe）x或（MnNiSi）1-x（CoFeGe）x具有特别的磁热和/或钙热性质，对施加的压力具有急性敏感性并且没有明显的磁滞损耗。
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公开(公告)号：EP0131043A1
公开(公告)日：1985-01-16
申请号：EP84900583.0
申请日：1983-12-29
CPC分类号： C07H21/00
摘要： Dans un procédé de phosphite transversal pour la préparation de polynucléotides, on fait réagir un nucléocide à résine réactive 5' avec un réactif de phosphore bifonctionnel (III) pour produire un intermédiaire de nucléosidophosphore de résine monofonctionnelle (III). Cet intermédiaire est condensé avec un nucléoside bloqué 5' par le réactif 3' pour produire un dinucléosidophosphite. Ce dernier est débloqué 5' et le cycle de réaction avec l'intermédiaire bifonctionnel et de condensation avec le nucléoside à réactif 3' bloqué 5' est répété pour construire une chaîne correspondant aux polynucléotides désirés. Le phosphite est converti en phosphate par oxydation pour produire le polynucléotide. Des structures et des procédés améliorés de liaison de la chaîne nucléotide sur la résine, et des techniques améliorées permettant de détacher le nucléotide final de la résine sont également décrits.
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公开(公告)号：EP2358372A1
公开(公告)日：2011-08-24
申请号：EP09825565.6
申请日：2009-11-09
发明人： MO, Yin-yuan
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： A61K31/7088
摘要： Novel small expressed microRNA molecules associated with physiological regulatory mechanisms and particularly in developmental control are provided herein. More particularly, the present invention relates to microRNA molecules that suppress cancerous cell growth and other cancer-related disorders by suppressing tumor promoting factors such as, for example, Ubc9. Further, it is contemplated that the use of the microRNA molecules hereof will improve the diagnoses, prevention and/or treatment and also the identification and development of pharmaceuticals that are effective in connection with cancer cell growth.
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6.发明公开INTERMETALLIC BONDED DIAMOND COMPOSITE COMPOSITION AND METHODS OF FORMING ARTICLES FROM SAME 审中-公开金属间结合剂金刚石复合体组合物方法的形成制品的THEREOF
公开(公告)号：EP1874972A2
公开(公告)日：2008-01-09
申请号：EP06748700.9
申请日：2006-03-24
CPC分类号： B22F3/12 , B22F3/10 , B22F2005/002 , B22F2009/043 , B22F2998/10 , C22C26/00 , C22C32/0084 , C22C2026/006 , B22F9/04 , B22F3/02
摘要： An intermetallic bonded diamond composite composition and methods of processing such a composition are provided by the present invention. The intermetallic bonded diamond composite composition preferably comprises a nickel aluminide (Ni3AI) binder and diamond particles dispersed within the nickel aluminide (Ni3AI) binder. Additionally, the composite composition has a processing temperature of at least about 1 ,200° C and is processed such that the diamond particles remain intact and are not converted to graphite or vaporized by the high-temperature process. Methods of forming the composite composition are also provided that generally comprise the steps of milling, pressing, and sintering the high-temperature intermetallic binder and diamond particles.
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公开(公告)号：EP1171119A1
公开(公告)日：2002-01-16
申请号：EP00926136.3
申请日：2000-04-20
CPC分类号： A61K31/7048 , A61K31/352 , A61K38/168 , Y10S514/893 , A61K31/35 , A61K31/70 , A61K2300/00
摘要： The present invention provides a method of treating or preventing certain medical conditions with isoflavones. More specifically, the invention provides a method of treating or preventing one or more of the following medical conditions: hepatic steatosis, steatohepatitis, insulin resistance, impaired glucose tolerance, syndrome X, abnormal platelet function, or abnormal vascular reactivity, with compositions containing isoflavones.
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