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    PROCESS FOR THE HYDROLYSIS OF CELLULOSE MEDIATED BY TERNARY COMPLEXES OF CELLULOSE, CLOSTRIDIUM THERMOCELLUM CELLS, AND CELLULASE EXPRESSED BY THESE CELLS
    8.
    发明公开
    PROCESS FOR THE HYDROLYSIS OF CELLULOSE MEDIATED BY TERNARY COMPLEXES OF CELLULOSE, CLOSTRIDIUM THERMOCELLUM CELLS, AND CELLULASE EXPRESSED BY THESE CELLS 审中-公开
    方法三重纤维素复合体，热纤梭菌细胞和这些细胞表达的纤维素酶SWITCHED纤维素水解

    公开(公告)号：EP2013355A2

    公开(公告)日：2009-01-14

    申请号：EP07811862.7

    申请日：2007-05-01

    申请人： The Trustees of Dartmouth College ,  Lynd, Lee R.

    发明人： LYND, Lee R. ,  ZHANG, Yi-heng Percival ,  LU, Yanpin

    IPC分类号： C12P19/14

    CPC分类号： C12P19/14

    摘要： Methods of utilizing reduced cellulase loads to hydrolyze cellulosic substrates are disclosed. The methods include determining an amount of purified cellulase necessary to substantially hydrolyze a quantity of cellulosic substrate in a period of time; reducing the amount of purified cellulase by a factor of between 2 and 5 to determine a reduced cellulase load; and introducing to the cellulosic substrate either (1 ) a microorganism expressing cell-bound cellulase in a concentration equal to the reduced cellulase load or (2) a fermentation agent that has been engineered to express cell-bound cellulase in a concentration equal to the reduced cellulase load under suitable conditions and for said period of time sufficient to allow substantial hydrolysis of the cellulosic substrate.

    Methods for inducing T cell tolerance to a tissue or organ graft
    9.
    发明公开
    Methods for inducing T cell tolerance to a tissue or organ graft 失效
    Verfahren zur Anregung von T-Zelltoleranz zu einem Gewebe- oder Organtransplantat

    公开(公告)号：EP1530973A2

    公开(公告)日：2005-05-18

    申请号：EP05075209.6

    申请日：1995-04-25

    申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： A61K39/00

    CPC分类号： A61K39/001 ,  A61K35/17 ,  A61K35/39 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/2875 ,  C07K2317/73 ,  Y10S514/885 ,  A61K2300/00

    摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.

    摘要翻译： 公开了在移植受体中诱导T细胞对组织或器官移植物的耐受性的方法。 所述方法涉及对受试者施用：1）同种异体细胞，其表达供体抗原，并且在细胞表面上具有配体，所述配体与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用; 和2）抑制配体与受体相互作用的受体拮抗剂。 在优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。 优选的gp39拮抗剂是抗gp39抗体。 同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。 本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。 还公开了一种用于治疗糖尿病的方法，包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。