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公开(公告)号：EP3383838A1
公开(公告)日：2018-10-10
申请号：EP16802033.7
申请日：2016-11-26
发明人： MORANDI, Bill , FANG, Xianjie , YU, Peng
IPC分类号： C07C253/30 , C07C255/03 , C07C255/07 , C07C255/19 , C07C255/31 , C07C255/33 , C07C255/34 , C07C255/37 , C07C255/46 , C07C255/47 , C07D209/76 , C07D209/86 , C07F7/08 , B01J31/14 , B01J31/24
CPC分类号： C07D209/76 , B01J31/143 , B01J31/24 , B01J2231/54 , B01J2531/847 , C07C253/30 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D209/86 , C07C255/33 , C07C255/46 , C07C255/47 , C07C255/37 , C07C255/35 , C07C255/03 , C07C255/31 , C07C255/19 , C07C255/07 , C07C255/34
摘要： The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation.
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公开(公告)号：EP2918576B1
公开(公告)日：2018-10-10
申请号：EP13854059.6
申请日：2013-11-08
IPC分类号： C07C253/30 , B01J25/00 , B01J31/24 , C07C209/26 , C07C209/48 , C07C211/19 , C07C255/47 , C07C263/10 , C07C265/14 , C07B61/00
CPC分类号： C07C255/47 , B01J31/24 , C07C211/19 , C07C211/38 , C07C265/14 , C07C2602/40 , C07C2602/42
摘要： A preparation method of an aldehyde compound of the present invention includes a step of reacting a compound represented by the following general formula (a1) with hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, and in the step, the amount of acrylonitrile included in the compound represented by the general formula (a1) is equal to or less than 200-fold by mole with respect to 1 mole of the metal belonging to Groups 8 to 10.
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公开(公告)号：EP2918577B1
公开(公告)日：2018-07-25
申请号：EP13853532.3
申请日：2013-11-08
IPC分类号： C07C253/34 , B01J25/00 , B01J31/24 , C07C209/26 , C07C209/48 , C07C211/19 , C07C253/30 , C07C255/47 , C07C263/10 , C07C265/14 , C07B61/00
CPC分类号： C07C263/10 , B01J31/24 , C07B63/00 , C07C209/26 , C07C211/19 , C07C253/30 , C07C253/34 , C07C255/47 , C07C265/14 , C07C2602/42
摘要： The purification method of an aldehyde compound of the present invention includes a step of neutralizing a reaction solution containing an aldehyde compound by adding water and a base compound to the reaction solution, and a step of distilling the neutralized reaction solution, in which the reaction solution is obtained by reacting a compound represented by the following Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, the phosphorus compound is represented by Formula (R 1 O) 3 P, and the base compound is at least one kind selected from among carbonate and hydrogen carbonate of metals of group I on the periodic table and carbonate and hydrogen carbonate of metals of group II on the periodic table.
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4.发明公开
公开(公告)号：EP3176151A1
公开(公告)日：2017-06-07
申请号：EP15197353.4
申请日：2015-12-01
发明人： FANG, Xianjie , MORANDI, Bill , PENG, Yu
IPC分类号： C07C253/30 , C07C255/03 , C07C255/07 , C07C255/19 , C07C255/31 , C07C255/33 , C07C255/34 , C07C255/37 , C07C255/46 , C07C255/47 , C07D209/76 , C07D209/86 , C07F7/08 , B01J31/14 , B01J31/24
CPC分类号： C07D209/76 , B01J31/143 , B01J31/24 , C07C253/30 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D209/86 , C07C255/33 , C07C255/46 , C07C255/47 , C07C255/37 , C07C255/35 , C07C255/03 , C07C255/31 , C07C255/19 , C07C255/07 , C07C255/34
摘要： The present invention refers to processes for catalytic reversible alkene-nitrile interconversion through controllable HCN-free transfer hydrocyanation.
摘要翻译： 本发明涉及通过可控的无HCN转移氢氰化反应的催化可逆烯烃 - 腈相互转化的方法。
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5.发明授权ANTIOXIDANT INFLAMMATION MODULATORS: C-17 HOMOLOGATED OLEANOLIC ACID DERIVATIVES 有权抗氧化剂炎症调节剂：C-17同源的烯醇酸衍生物
公开(公告)号：EP2271658B1
公开(公告)日：2016-11-09
申请号：EP09732769.6
申请日：2009-04-20
IPC分类号： C07D317/28 , C07D257/04 , C07D261/08 , C07D493/08 , C07D209/48 , C07D303/36 , C07C255/47
CPC分类号： C07C255/47 , C07C53/18 , C07D209/48 , C07D257/04 , C07D261/08 , C07D303/36 , C07D317/28 , C07D493/08 , C07F9/09 , C07J63/008
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公开(公告)号：EP3080072A1
公开(公告)日：2016-10-19
申请号：EP14869147.0
申请日：2014-12-10
发明人： BUNKER, Kevin Duane
IPC分类号： C07C211/41
CPC分类号： C07C331/06 , B01J27/128 , B01J31/04 , B01J31/2217 , B01J31/28 , B01J2231/482 , B01J2531/007 , B01J2531/845 , C07C17/013 , C07C17/10 , C07C23/24 , C07C29/50 , C07C35/24 , C07C201/00 , C07C207/02 , C07C209/42 , C07C211/38 , C07C247/14 , C07C249/12 , C07C251/42 , C07C251/48 , C07C253/30 , C07C255/47 , C07C255/62 , C07C255/64 , C07C263/16 , C07C265/10 , C07C2602/38
摘要： Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.
摘要翻译： 本文公开的是通式（I）的化合物，以及使用第Ⅶ族或第Ⅸ族过渡金属化合物合成取代的双环[1.1.1]戊烷的方法。
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公开(公告)号：EP2918575A4
公开(公告)日：2016-07-13
申请号：EP13853896
申请日：2013-11-08
申请人： MITSUI CHEMICALS INC
IPC分类号： C07C253/30 , B01J25/00 , B01J31/24 , C07B61/00 , C07C209/26 , C07C209/48 , C07C211/19 , C07C255/47 , C07C263/10 , C07C265/14
CPC分类号： C07C255/47 , B01J23/75 , B01J25/00 , B01J31/185 , B01J31/2234 , B01J31/24 , B01J2231/321 , B01J2531/821 , B01J2531/822 , B01J2531/842 , B01J2531/845 , C07C209/26 , C07C209/48 , C07C211/19 , C07C211/38 , C07C253/30 , C07C263/10 , C07C265/14 , C07C2602/20 , C07C2602/40
摘要： A preparation method of an aldehyde compound of the present invention includes a step of reacting the compound represented by the following general formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound including 0.01 ppmmol to 10 ppmmol of a metal belonging to Groups 8 to 10 with respect to 1 mole of the compound and a phosphorus compound, and the amount of a chlorine portion in the reaction system in the step is equal to or less than 1.5 parts by weight with respect to 1 part by weight of the metal belonging to Groups 8 to 10.
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公开(公告)号：EP2635550B1
公开(公告)日：2016-01-27
申请号：EP11776193.2
申请日：2011-10-28
发明人： ANGERMANN, Alfred , LEHR, Stefan , BOJACK, Guido , FISCHER, Reiner , HÄUSER-HAHN, Isolde , HEINEMANN, Ines , GATZWEILER, Elmar , ROSINGER, Christopher, Hugh , VOERSTE, Arnd , FEUCHT, Dieter
IPC分类号： C07C69/007 , C07C69/013 , C07C69/24 , C07C69/30 , C07C69/757 , C07C69/96 , A01N35/02 , A01N35/10 , A01N37/08 , A01N37/34 , A01N43/22 , A01N43/26 , A01N43/32 , A01P13/00 , C07C49/747 , C07C49/753 , C07C49/757 , C07C62/38 , C07C251/38 , C07C251/40 , C07C251/52
CPC分类号： C07C69/24 , A01N35/02 , A01N35/10 , A01N37/08 , A01N37/34 , A01N43/26 , A01N43/30 , A01N43/32 , A01N43/36 , A01N43/80 , A01N43/84 , A01N43/86 , A01N47/18 , C07C45/513 , C07C49/67 , C07C49/753 , C07C49/757 , C07C67/14 , C07C67/29 , C07C67/313 , C07C68/02 , C07C69/007 , C07C69/013 , C07C69/157 , C07C69/30 , C07C69/738 , C07C69/757 , C07C69/96 , C07C233/58 , C07C251/40 , C07C251/42 , C07C251/52 , C07C255/40 , C07C255/47 , C07C271/10 , C07C271/28 , C07C317/24 , C07C323/22 , C07C327/28 , C07C331/06 , C07C331/10 , C07C333/08 , C07C2602/22 , C07D207/46 , C07D263/46 , C07D263/58 , C07D277/34 , C07D295/192 , C07D307/18 , C07D309/12 , C07D317/12 , C07D319/06 , C07D321/06 , C07D327/06 , C07D339/06 , C07D339/08 , C07F9/65515
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公开(公告)号：EP2822930B1
公开(公告)日：2016-01-20
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28 , A61K31/506 , C07C255/47 , C07C313/06 , C07D405/06 , C07C229/50 , C07C331/14
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
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10.发明公开HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF 有权HEXAHYDROPENTALENODERIVATE，方法和使用中医药
公开(公告)号：EP2865666A1
公开(公告)日：2015-04-29
申请号：EP13809973.4
申请日：2013-06-25
发明人： GU, Zheng , QIU, Guanpeng , WU, Wuyong , KANG, Panpan , ZHANG, Zongyuan , CHEN, Gang , LAN, Chengsheng , WEI, Yonggang , WEN, Jiaping , ZHU, Guozhi , LU, Yonghua , WANG, Heran , WANG, Yincai , YUAN, Mingyun , YE, Kangzhi , SU, Guizhuan , TANG, PengCho
IPC分类号： C07D207/16 , C07D209/52 , C07D405/12 , A61K31/40 , A61K31/403 , A61K31/4025 , C07C213/02 , C07C217/52 , C07C215/44 , C07C255/47 , C07C253/30 , C07C219/24 , C07C211/41 , C07C209/62 , A61P3/10 , A61P9/10 , A61P25/00 , A61P13/12 , A61P5/50 , A61P3/04 , A61P3/06
CPC分类号： C07D207/16 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K45/06 , C07C213/02 , C07C217/52 , C07C249/08 , C07C253/30 , C07C255/47 , C07C2601/02 , C07C2602/22 , C07C2603/94 , C07D209/52 , C07D405/12 , C07C251/34 , A61K2300/00
摘要： The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.
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