公开(公告)号：EP2217610A1

公开(公告)日：2010-08-18

申请号：EP08851633.1

申请日：2008-11-21

申请人： Achaogen, Inc.

发明人： AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

IPC分类号： C07H15/222 ,  A61K31/7036 ,  A61P31/04

CPC分类号： C07H15/224 ,  A61K31/7036 ,  C07H15/222 ,  C07H15/236 ,  Y02A50/473

摘要： Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

摘要翻译： 公开了具有抗菌活性的结构（I）的化合物，包括其立体异构体，药学上可接受的盐和前药，其中Q1，Q2，Q3，R8和R9如本文所定义。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。

公开(公告)号：EP3150617A1

公开(公告)日：2017-04-05

申请号：EP16195678.4

申请日：2008-11-21

申请人： Achaogen, Inc.

发明人： AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

IPC分类号： C07H15/222 ,  A61K31/7036 ,  A61P31/04

摘要： Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

摘要翻译： 公开了具有抗菌活性的结构（I）的化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q 1，Q 2，Q 3，R 8和R 9如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：EP2250171A2

公开(公告)日：2010-11-17

申请号：EP09743117.5

申请日：2009-02-12

申请人： Achaogen, Inc.

发明人： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James ,  LINSELL, Martin, S ,  GOLDBLUM, Adam, Aaron ,  GRIFFIN, John, H. ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D.

IPC分类号： C07D471/14 ,  C07D498/14 ,  C07D513/14 ,  A61K31/554 ,  A61P31/04

CPC分类号： C07D471/14 ,  C07D498/14 ,  C07D513/14

摘要： Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：EP2205600A1

公开(公告)日：2010-07-14

申请号：EP08842987.3

申请日：2008-10-24

申请人： Achaogen, Inc.

发明人： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst

IPC分类号： C07D471/04 ,  A61K31/4353 ,  A61P31/04

CPC分类号： C07D471/04

摘要： Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

公开(公告)号：EP2217610B1

公开(公告)日：2016-11-02

申请号：EP08851633.1

申请日：2008-11-21

申请人： Achaogen, Inc.

发明人： AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

IPC分类号： C07H15/222 ,  A61K31/7036 ,  A61P31/04

CPC分类号： C07H15/224 ,  A61K31/7036 ,  C07H15/222 ,  C07H15/236 ,  Y02A50/473

摘要： Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.