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1.发明公开1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基 - 取代的杂环衍生物及其前列腺素D2受体的调节剂
公开(公告)号：EP2590944A1
公开(公告)日：2013-05-15
申请号：EP11752340.7
申请日：2011-07-04
发明人： AISSAOUI, Hamed , BOSS, Christoph , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , RISCH, Philippe , SIEGRIST, Romain , FRETZ, Heinz
IPC分类号： C07D209/44 , C07D217/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , A61K31/4035 , A61K31/472
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： 302 Abstract The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), O Y R 5 R 6 N R 2 R 3 R 4 X Z R 1 R 7 R 7 R 10 n (I) 5 wherein X, Y, Z, n, R 1, R 2, R 3, R 4, R 5, R 6, R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. 10
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公开(公告)号：EP2318367A1
公开(公告)日：2011-05-11
申请号：EP09738535.5
申请日：2009-04-29
发明人： AISSAOUI, Hamed , BOSS, Christoph , KOBERSTEIN, Ralf , SIEGRIST, Romain , SIFFERLEN, Thierry , TRACHSEL, Daniel
IPC分类号： C07D211/56 , C07D401/12 , C07D417/14 , C07D471/04 , C07D493/04 , A61K31/4523 , A61P25/00
CPC分类号： C07D211/56 , C07D401/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
摘要： The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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3.发明授权HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权国际化合物衍生物的衍生物维生素ALS PROSTAGLANDIN-D2-REZEPTORMODULATOREN
公开(公告)号：EP2794563B1
公开(公告)日：2017-02-22
申请号：EP12823031.5
申请日：2012-12-20
IPC分类号： C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D417/06 , A61K31/47
CPC分类号： C07D417/06 , C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06
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4.发明授权3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权3-（杂芳基 - 氨基）-1,2,3,4-四氢-9H-咔唑衍生物及其前列腺素D2受体调节剂
公开(公告)号：EP2558447B1
公开(公告)日：2014-09-17
申请号：EP11715042.5
申请日：2011-03-21
发明人： AISSAOUI, Hamed , FRETZ, Heinz , HAZEMANN, Julien , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC分类号： C07D209/88 , A61K31/403 , A61P11/06
CPC分类号： C07D209/88
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公开(公告)号：EP2318367B1
公开(公告)日：2013-03-20
申请号：EP09738535.5
申请日：2009-04-29
发明人： AISSAOUI, Hamed , BOSS, Christoph , KOBERSTEIN, Ralf , SIEGRIST, Romain , SIFFERLEN, Thierry , TRACHSEL, Daniel
IPC分类号： C07D211/56 , C07D401/12 , C07D417/14 , C07D471/04 , C07D493/04 , A61K31/4523 , A61P25/00
CPC分类号： C07D211/56 , C07D401/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
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公开(公告)号：EP2521715A1
公开(公告)日：2012-11-14
申请号：EP11702702.9
申请日：2011-01-04
IPC分类号： C07D213/56 , C07D213/64 , C07D295/185 , A61K31/495 , A61K31/496 , A61P33/02 , A61P33/06
CPC分类号： C07D213/56 , C07D213/64 , C07D295/185
摘要： The invention relates to piperazine derivatives of Formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
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7.发明公开NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS 有权新的恶唑烷酮衍生物及其作为食欲素受体拮抗剂的应用
公开(公告)号：EP2430004A2
公开(公告)日：2012-03-21
申请号：EP10721852.1
申请日：2010-05-11
发明人： AISSAOUI, Hamed , BOSS, Christoph , BROTSCHI, Christine , GUDE, Markus , SIEGRIST, Romain , SIFFERLEN, Thierry , WILLIAMS, Jodi T.
IPC分类号： C07D263/18 , A61K31/42 , A61K31/422 , C07D263/56 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
CPC分类号： C07D263/18 , C07D263/56 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R
3 and R
4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.-
公开(公告)号：EP2307417A2
公开(公告)日：2011-04-13
申请号：EP09769759.3
申请日：2009-06-24
IPC分类号： C07D487/04 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/04
摘要： The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5- a]pyrazine derivatives of formula (I) wherein R
1 , R
2 , R
3 , and R
4 are as described n the description, to salts, especially pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments; especially as orexin receptor antagonists.摘要翻译： 本发明涉及式（I）的5,6,7,8-四氢 - 咪唑并[1,5-a]吡嗪衍生物，其中R 1，R 2，R 3和R 4如描述中所述， 盐，特别是其药学上可接受的盐，以及这些化合物作为药物的用途; 特别是作为食欲素受体拮抗剂。
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9.发明公开PYRAZOLE COMPOUNDS AND THEIR USE AS T-TYPE CALCIUM CHANNEL BLOCKERS 审中-公开PYRAZOLVERBINDUNGEN UND DEREN VERWENDUNG ALS T-TYP-CALCIUMKANALBLOCKER
公开(公告)号：EP3152199A1
公开(公告)日：2017-04-12
申请号：EP15728640.2
申请日：2015-06-02
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/40 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61K31/415 , A61K31/4155 , A61K31/4439 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P35/00
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04
摘要： wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
摘要翻译： 其中X，Y，R 1，R 2，（R 4）n和（R 5）m如说明书中所定义，以及这些化合物的药学上可接受的盐。 这些化合物可用作钙T通道阻滞剂。
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10.发明公开1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 审中-公开1-苯基 - 取代的杂环基 - 衍生物及其前列腺素D2受体调节剂
公开(公告)号：EP2885307A1
公开(公告)日：2015-06-24
申请号：EP13762258.5
申请日：2013-07-04
IPC分类号： C07D513/04 , A61K31/4353 , A61P11/00 , A61P17/00 , A61P37/00
CPC分类号： C07D513/04
摘要： The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein Y, Z, R
1 , R
2 , R
3 and R
4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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