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公开(公告)号：EP3071567A1
公开(公告)日：2016-09-28
申请号：EP14799475.0
申请日：2014-11-18
发明人： BUR, Daniel , GRISOSTOMI, Corinna , NAYLER, Oliver , REMEN, Lubos , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D471/04 , C07D471/14 , C07D498/12 , C07D513/14 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P19/10 , A61P35/00 , A61P1/00 , A61P3/10 , A61P9/12 , A61P25/00
CPC分类号： C07D471/14 , C07D471/04 , C07D498/12 , C07D513/14
摘要： The present invention relates to compounds of the formula (I), wherein R
1a , R
1b , R
2 , R
3 , and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.摘要翻译： 其中R1a，R1b，R2，R3和X如本说明书所述，其制备方法，其药学上可接受的盐及其作为药物的用途，含有一种或多种式（I）化合物的药物组合物， 制备式（I）化合物的方法，特别是其作为TPH调节剂的用途。
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公开(公告)号：EP1824851A2
公开(公告)日：2007-08-29
申请号：EP05824541.6
申请日：2005-12-08
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry , WEBER, Hans-Peter , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995 , A61P13/12
CPC分类号： C07D471/08
摘要： The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I) or (I’) and especially their use as inhibitors of renin.
摘要翻译： 本发明涉及一种新的3,9-二氮杂双环[3.3.1]壬烯衍生物及其对映异构体及其在制备药物组合物中作为活性成分的用途。 本发明还涉及相关方面，包括制备化合物的方法，含有至少一种式（I）或（I'）化合物的药物组合物，特别是它们作为肾素抑制剂的用途。
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公开(公告)号：EP1622564A2
公开(公告)日：2006-02-08
申请号：EP04729414.5
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC分类号： A61K6/00
CPC分类号： C07D471/10
摘要： The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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4.发明公开NOVEL 3,4-DISUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES 有权3,4-DISUBSTITUIERTE 1,2,3,4-四氢吡啶衍生物
公开(公告)号：EP1620403A1
公开(公告)日：2006-02-01
申请号：EP04729420.2
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D211/78 , A61K31/451
CPC分类号： C07D211/78
摘要： The invention relates to novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1519920A1
公开(公告)日：2005-04-06
申请号：EP03722566.1
申请日：2003-04-29
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D211/78 , C07D405/12 , A61K31/451 , A61P9/00
CPC分类号： C07D405/12 , C07D211/78
摘要： The invention relates to novel tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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6.发明授权TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE 有权三环咪唑化合物作为TRYPTOPHAN HYDROXYLASE的抑制剂
公开(公告)号：EP3071567B1
公开(公告)日：2017-09-06
申请号：EP14799475.0
申请日：2014-11-18
发明人： BUR, Daniel , GRISOSTOMI, Corinna , NAYLER, Oliver , REMEN, Lubos , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D471/04 , C07D471/14 , C07D498/12 , C07D513/14 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P19/10 , A61P35/00 , A61P1/00 , A61P3/10 , A61P9/12 , A61P25/00
CPC分类号： C07D471/14 , C07D471/04 , C07D498/12 , C07D513/14
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公开(公告)号：EP3071578A1
公开(公告)日：2016-09-28
申请号：EP14799473.5
申请日：2014-11-18
发明人： BUR, Daniel , GRISOSTOMI, Corinna , NAYLER, Oliver , REMEN, Lubos , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D513/14 , A61K31/437 , A61P11/06
CPC分类号： C07D513/14
摘要： wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
摘要翻译： 其中R，R 1a，R 1b，R 2，R 3和X如本说明书所述，其制备方法，其药学上可接受的盐及其作为药物的用途，含有一种或多种式（I）化合物的药物组合物， ，用于制备式（I）化合物的方法，特别是其用作TPH调节剂。
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8.发明授权7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES 有权7-芳基 - 3,9-二氮杂双环[3.3.1]壬-6-烯衍生物及其AS肾素抑制剂用于治疗高血压的治疗，心血管疾病和肾病
公开(公告)号：EP1501830B1
公开(公告)日：2011-10-05
申请号：EP03727287.9
申请日：2003-04-08
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WEBER, Hans-Peter , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995
CPC分类号： C07D471/08 , A61K31/4995 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
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公开(公告)号：EP1981847A1
公开(公告)日：2008-10-22
申请号：EP07705752.9
申请日：2007-01-31
发明人： BEZENCON, Olivier , BUR, Daniel , CORMINBOEUF, Olivier , DUBE, Daniel , GRISOSTOMI, Corinna , MACDONALD, Dwight , MCKAY, Dan , POWELL, David , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , SCHEIGETZ, John , THERIEN, Michel , WELLER, Thomas
IPC分类号： C07D211/70 , C07D451/02 , C07D471/08 , A61K31/439 , A61K31/4418 , A61P9/00 , C07D401/14 , C07D413/10 , C07D413/14 , C07D211/34
CPC分类号： C07D211/78 , C07D211/34 , C07D211/70 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08
摘要： The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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10.发明公开DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS 审中-公开DIAZABICYCLONONENDERIVATE及其作为肾素抑制剂
公开(公告)号：EP1692133A1
公开(公告)日：2006-08-23
申请号：EP04819638.0
申请日：2004-11-30
发明人： BEZENCON, Olivier , RICHARD-BILDSTEIN, Sylvia , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , SIFFERLEN, Thierry
IPC分类号： C07D471/08 , A61K31/4995 , A61P9/12 , C07D241/00 , C07D221/00
CPC分类号： C07D471/08
摘要： The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I), wherein Z is 0 or 1, one of m, n is 0 and the other is 1, and their use as inhibitors of renin.
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