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1.发明公开METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 有权用于生产L-氨基酸USING肠杆菌科细菌
公开(公告)号：EP1853714A1
公开(公告)日：2007-11-14
申请号：EP06703761.4
申请日：2006-01-18
申请人： Ajinomoto Co., Inc.
发明人： PTITSYN, Leonid Romanovich , ALTMAN, Irina, Borisovna , KOTLIAROVA, Veronika Aleksandrovna , KOZLOV, Yury Ivanovich
IPC分类号： C12P13/04
CPC分类号： C12P13/04
摘要： There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of N-acetylglucosamine permease encoded by the nagE gene.
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公开(公告)号：EP2192170A1
公开(公告)日：2010-06-02
申请号：EP08829698.3
申请日：2008-09-03
申请人： Ajinomoto Co., Inc.
发明人： TERASHITA, Masaru , USUDA, Yoshihiro , MATSUI, Kazuhiko , YAMPOLSKAYA, Tatyana Abramovna , STOYNOVA, Natalia Viktorovna , EREMINA, Natalia Sergeevna , ALTMAN, Irina Borisovna , PTITSYN, Leonid Romanovich
CPC分类号： C12P13/06 , C12N9/0008 , C12P13/08 , C12P13/22
摘要： A microorganism which has an ability to produce an L-amino acid selected from the group consisting of L-lysine, L-threonine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine and has been modified so that activity of pyruvate synthase or pyruvate:NADP + oxidoreductase is increased is cultured in a medium such as medium containing ethanol or an aliphatic acid as a carbon source to produce and accumulate the L-amino acid in the medium or cells, and the L-amino acid is collected from the medium or the cells.
摘要翻译： 具有产生选自L-赖氨酸，L-苏氨酸，L-色氨酸，L-苯丙氨酸，L-缬氨酸，L-亮氨酸，L-异亮氨酸和L-丝氨酸的L-氨基酸的能力的微生物 并且已经被修饰以使得丙酮酸合酶或丙酮酸：NADP +氧化还原酶的活性增加的培养基在诸如含有乙醇或脂肪酸作为碳源的培养基中培养并在培养基或细胞中积累L-氨基酸， 并从培养基或细胞收集L-氨基酸。
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公开(公告)号：EP2192170B1
公开(公告)日：2017-02-15
申请号：EP08829698.3
申请日：2008-09-03
申请人： Ajinomoto Co., Inc.
发明人： TERASHITA, Masaru , USUDA, Yoshihiro , MATSUI, Kazuhiko , YAMPOLSKAYA, Tatyana Abramovna , STOYNOVA, Natalia Viktorovna , EREMINA, Natalia Sergeevna , ALTMAN, Irina Borisovna , PTITSYN, Leonid Romanovich
CPC分类号： C12P13/06 , C12N9/0008 , C12P13/08 , C12P13/22
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4.发明授权A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 有权方法用于生产L-氨基酸的使用肠杆菌科细菌
公开(公告)号：EP2046949B1
公开(公告)日：2014-01-15
申请号：EP07768453.8
申请日：2007-07-12
申请人： Ajinomoto Co., Inc.
发明人： PTITSYN, Leonid Romanovich , ALTMAN, Irina Borisovna , KOTLIAROVA, Veronika Aleksandrovna , MOKHOVA, Olga, Nikolaevna , YAMPOLSKAYA, Tatyana Abramovna , KOZLOV, Yury Ivanovich , TERASHITA, Masaru , USUDA, Yoshihiro , MATSUI, Kazuhiko
IPC分类号： C12N9/04
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/10 , C12P13/14 , C12P13/222 , C12P13/227 , C12P13/24 , C12Y101/01002
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5.发明公开A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 有权方法用于生产L-氨基酸的使用肠杆菌科细菌
公开(公告)号：EP2046949A2
公开(公告)日：2009-04-15
申请号：EP07768453.8
申请日：2007-07-12
申请人： Ajinomoto Co., Inc.
发明人： PTITSYN, Leonid Romanovich , ALTMAN, Irina Borisovna , KOTLIAROVA, Veronika Aleksandrovna , MOKHOVA, Olga, Nikolaevna , YAMPOLSKAYA, Tatyana Abramovna , KOZLOV, Yury Ivanovich , TERASHITA, Masaru , USUDA, Yoshihiro , MATSUI, Kazuhiko
IPC分类号： C12N9/04
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/10 , C12P13/14 , C12P13/222 , C12P13/227 , C12P13/24 , C12Y101/01002
摘要： A method for producing an L-amino acid is described, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of a wild-type alcohol dehydrogenase encoded by the adhE gene or a mutant alcohol dehydrogenase which is resistant to aerobic inactivation.
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6.发明授权METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY 有权用于生产L-氨基酸USING肠杆菌科细菌
公开(公告)号：EP1853714B1
公开(公告)日：2008-11-26
申请号：EP06703761.4
申请日：2006-01-18
申请人： Ajinomoto Co., Inc.
发明人： PTITSYN, Leonid Romanovich , ALTMAN, Irina, Borisovna , KOTLIAROVA, Veronika Aleksandrovna , KOZLOV, Yury Ivanovich
IPC分类号： C12P13/04
CPC分类号： C12P13/04
摘要： There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of N-acetylglucosamine permease encoded by the nagE gene.
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