公开(公告)号：EP1942948A2

公开(公告)日：2008-07-16

申请号：EP06837005.5

申请日：2006-11-03

申请人： Alnylam Pharmaceuticals Inc.

发明人： SAH, Dinah, Wen-Yee ,  FRANK-KAMENETSKY, Maria ,  GEICK, Anke ,  HADWIGER, Philipp ,  ROEHL, Ingo ,  TAN, Pamela ,  VORNLOCHER, Hans-Peter

IPC分类号： A61K48/00 ,  C07J17/00 ,  C07H21/02 ,  C12N5/10 ,  C12N5/08 ,  C07F9/6533

CPC分类号： C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3515 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell

公开(公告)号：EP1941059A2

公开(公告)日：2008-07-09

申请号：EP06827135.2

申请日：2006-10-27

申请人： Alnylam Pharmaceuticals Inc.

发明人： SAH, Dinah Wen-Yee ,  HADWIGER, Philipp ,  ROEHL, Ingo ,  BRAMLAGE, Birgit ,  TAN, Pamela ,  VORNLOCHER, Hans-Peter ,  BUMCROT, David

IPC分类号： C12Q1/68 ,  A01N43/04 ,  C07H21/04 ,  A61K31/07

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.

公开(公告)号：EP1765847A2

公开(公告)日：2007-03-28

申请号：EP05780090.6

申请日：2005-05-27

申请人： Alnylam Pharmaceuticals Inc.

发明人： VORNLOCHER, Hans-Peter ,  HADWIGER, Philipp ,  ZIMMERMANN, Tracy, Stage ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil G. ,  ROEHL, Ingo ,  AKINC, Akin

IPC分类号： C07H21/04 ,  A01N43/04

CPC分类号： C07H21/02 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/3231 ,  C12N2310/53 ,  C12N2320/51 ,  C12N2310/3521 ,  C12N2310/3525 ,  C12N2310/3527

摘要： This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.