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公开(公告)号：EP3919619A1
公开(公告)日：2021-12-08
申请号：EP21157896.8
申请日：2016-07-15
发明人： JADHAV, Vasant , MAIER, Martin , ZLATEV, Ivan , AKINC, Akin , RAJEEV, Kallanthottathil G. , NAIR, Jayaprakash K. , KANDASAMY, Pachamuthu , MANOHARAN, Muthiah
IPC分类号： C12N15/113
摘要： The present invention relates to a multi-targeted molecule comprising a first double-stranded siRNA molecule and a second double-stranded siRNA molecule, wherein the first siRNA and the second siRNA are covalently linked to each other, and wherein at least one ligand is conjugated with the multi-targeted molecule.
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公开(公告)号：EP3202760B1
公开(公告)日：2019-08-21
申请号：EP17000424.6
申请日：2012-01-11
发明人： RAJEEV, Kallanthottathil G. , MANOHARAN, Muthiah , JAYARAMAN, Muthusamy , MAIER, Martin , JAYAPRAKASH, Narayanannair K. , BUTLER, David
IPC分类号： C07D207/14 , C07D307/12 , C08L71/02 , C12N15/88 , A61K9/127
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公开(公告)号：EP1765847A2
公开(公告)日：2007-03-28
申请号：EP05780090.6
申请日：2005-05-27
发明人： VORNLOCHER, Hans-Peter , HADWIGER, Philipp , ZIMMERMANN, Tracy, Stage , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil G. , ROEHL, Ingo , AKINC, Akin
CPC分类号： C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/53 , C12N2320/51 , C12N2310/3521 , C12N2310/3525 , C12N2310/3527
摘要： This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
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公开(公告)号：EP3983077A1
公开(公告)日：2022-04-20
申请号：EP20826062.0
申请日：2020-06-16
发明人： NAIR, Jayaprakash K. , MAIER, Martin , JADHAV, Vasant , MILSTEIN, Stuart , BROWN, Kirk , RAJEEV, Kallanthottathil G. , MANOHARAN, Muthiah , KEL'IN, Alexander V. , JAYARAMAN, Muthusamy , CHARISSE, Klaus , CASTORENO, Adam , THEILE, Christopher S. , FITZGERALD, Kevin , PARMAR, Rubina G.
IPC分类号： A61P25/28 , C12N15/113
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公开(公告)号：EP2999785B1
公开(公告)日：2018-04-04
申请号：EP14730051.1
申请日：2014-05-22
发明人： SEHGAL, Alfica , CHARISSE, Klaus , BETTENCOURT, Brian , MAIER, Martin , RAJEEV, Kallanthottathil G. , HINKLE, Gregory , MANOHARAN, Muthiah
IPC分类号： C12N15/113 , A61K31/712 , A61K31/713 , A61P1/16 , A61P11/00 , A61P35/00
CPC分类号： C12N15/113 , A61K31/712 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/331 , C12N2310/332 , C12N2310/343 , C12N2310/344 , C12N2310/346 , C12N2310/351 , C12N2320/32 , C12N2320/34 , C12N2320/51 , C12N2330/30 , C12N2310/322 , C12N2310/3533 , C12N2310/3521
摘要： The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.
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公开(公告)号：EP1791567B1
公开(公告)日：2015-07-29
申请号：EP05786618.8
申请日：2005-08-10
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K47/54 , A61K47/543 , A61K47/551 , A61K47/554 , C07F9/06 , C12N15/111 , C12N15/87 , C12N2310/113 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/51
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公开(公告)号：EP3544617A1
公开(公告)日：2019-10-02
申请号：EP17873158.4
申请日：2017-11-22
发明人： THEILE, Christopher , MILSTEIN, Stuart , SCHLEGEL, Mark K. , JANAS, Maja , JADHAV, Vasant R. , FOSTER, Donald , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil G. , JAYARAMAN, Muthusamy , KEL'IN, Alexander V. , MATSUDA, Shigeo , CHARISSE, Klaus , NAIR, Jayaprakash K. , MAIER, Martin A. , SEHGAL, Alfica , BROWN, Christopher
IPC分类号： A61K31/713 , C07H21/00 , C12N15/113
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公开(公告)号：EP3324980A1
公开(公告)日：2018-05-30
申请号：EP16828302.6
申请日：2016-07-15
发明人： JADHAV, Vasant , MAIER, Martin , ZLATEV, Ivan , AKINC, Akin , RAJEEV, Kallanthottathil G. , NAIR, Jayaprakash K. , KANDASAMY, Pachamuthu , MANOHARAN, Muthiah
IPC分类号： A61K31/713 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/113 , A61K47/549 , A61K47/55 , C07H21/00 , C12N15/111 , C12N2310/20 , C12N2310/3519 , C12N2310/51 , C12N2320/31
摘要： The present invention relates, in general to, compounds, compositions and methods useful for modulating gene expression of multiple target nucleic acids by a single chemical entity.
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公开(公告)号：EP3234141A1
公开(公告)日：2017-10-25
申请号：EP15871104.4
申请日：2015-12-17
发明人： JADHAV, Vasant , MARAGANORE, John , MAIER, Martin , RAJEEV, Kallanthottathil G. , MANOHARAN, Muthiah , AKINC, Akin , ZLATEV, Ivan
IPC分类号： C12N15/113
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/113 , C12N2310/315 , C12N2310/3183 , C12N2310/319 , C12N2310/3231 , C12N2310/3341 , C12N2310/346 , C12N2310/351 , C12N2310/322 , C12N2310/3533 , C12N2310/321 , C12N2310/3527 , C12N2310/3525 , C12N2310/3521
摘要： The present invention relates, in general to agents that modulate the pharmacological activity of conjugated siRNAs.
摘要翻译： 本发明一般涉及调节缀合的siRNA的药理学活性的药剂。
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公开(公告)号：EP3802827A1
公开(公告)日：2021-04-14
申请号：EP19803000.9
申请日：2019-05-16
发明人： MATSUDA, Shigeo , SCHLEGEL, Mark K. , JANAS, Maja , JADHAV, Vasant R. , MAIER, Martin , CHARISSE, Klaus , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil G. , NAIR, Jayaprakash K.
IPC分类号： C12N15/113
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