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1.发明授权Verfahren zu Herstellung von PULVERFÖRMIGEn SOLUBILISATIONSHILFSSTOFFEn FÜR FESTE PHARMAZEUTISCHE DARREICHUNGSFORMEN 有权过程用于制备粉状SOLUBILISATIONSHILFSSTOFFEn的固体药物的药物形式
公开(公告)号：EP1169023B1
公开(公告)日：2004-01-21
申请号：EP00914148.2
申请日：2000-03-17
IPC分类号： A61K9/20
CPC分类号： A61K9/2013 , A61K9/2027
摘要： The invention relates to additives in powder form for use in solid pharmaceutical presentation forms. Said aids contain a pharmaceutically acceptable polymer and a liquid or semi-solid surface-active substance with solubilizing action.
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公开(公告)号：EP1223960A2
公开(公告)日：2002-07-24
申请号：EP00972786.8
申请日：2000-10-17
CPC分类号： A61K9/5138 , A61K9/5084 , A61K9/5146
摘要： The invention relates to solid pharmaceutical galenic forms comprising an agent in the form of a physical mixture of two different preparations with regard to the physical state of the agent.
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3.发明公开PULVERFÖRMIGE SOLUBILISATIONSHILFSSTOFFE FÜR FESTE PHARMAZEUTISCHE DARREICHUNGSFORMEN 有权粉SOLUBILISATIONSHILFSSTOFFE固体药物剂型
公开(公告)号：EP1169023A1
公开(公告)日：2002-01-09
申请号：EP00914148.2
申请日：2000-03-17
IPC分类号： A61K9/20
CPC分类号： A61K9/2013 , A61K9/2027
摘要： The invention relates to additives in powder form for use in solid pharmaceutical presentation forms. Said aids contain a pharmaceutically acceptable polymer and a liquid or semi-solid surface-active substance with solubilizing action.
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4.发明授权VERFAHREN ZUR HERSTELLUNG VON FESTEN CYCLODEXTRINHALTIGEN DOSIERUNGSFORMEN 有权PROCESS FOR SOLID环糊精剂型的制备
公开(公告)号：EP1158962B1
公开(公告)日：2002-12-04
申请号：EP00916925.1
申请日：2000-03-10
CPC分类号： A61K31/192 , A01N25/08 , A01N25/10 , A61K8/0216 , A61K8/738 , A61K8/86 , A61K9/2031 , A61K9/205 , A61K9/2095 , A61K31/565 , A61K2800/56 , A61Q19/00
摘要： The invention relates to a method for producing solid dosage forms containing at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 °C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.
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5.发明公开VERFAHREN ZUR HERSTELLUNG VON FESTEN CYCLODEXTRINHALTIGEN DOSIERUNGSFORMEN 有权PROCESS FOR SOLID环糊精剂型的制备
公开(公告)号：EP1158962A1
公开(公告)日：2001-12-05
申请号：EP00916925.1
申请日：2000-03-10
CPC分类号： A61K31/192 , A01N25/08 , A01N25/10 , A61K8/0216 , A61K8/738 , A61K8/86 , A61K9/2031 , A61K9/205 , A61K9/2095 , A61K31/565 , A61K2800/56 , A61Q19/00
摘要： The invention relates to a method for producing solid dosage forms containing at least one physiologically compatible polymer binding agent, at least one active agent and at least one cyclodextrin as components. According to the method, the components are mixed and plasticised at a temperature below 220 °C, without the addition of a solvent. The plastic mixture obtained is shaped into the dosage form. The invention also relates to the dosage forms obtained by said method.
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公开(公告)号：EP1077676A2
公开(公告)日：2001-02-28
申请号：EP99922158.3
申请日：1999-05-04
发明人： HEGER, Robert , AUWETER, Helmut , PFLÜGER, Peter , BREITENBACH, Jörg , BINDER, Rudolf , ZEIDLER, Jürgen , BERNDL, Gunther
IPC分类号： A61K9/00
CPC分类号： A61K9/5123 , A61K9/0095 , A61K9/1617 , A61K9/1658 , A61K9/5169 , A61K38/13
摘要： The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.
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公开(公告)号：EP0999756A1
公开(公告)日：2000-05-17
申请号：EP98943754.6
申请日：1998-07-21
发明人： BERNDL, Gunther , BREITENBACH, Jörg
摘要： The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm3 for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.
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公开(公告)号：EP0912190A1
公开(公告)日：1999-05-06
申请号：EP97931788.0
申请日：1997-07-07
发明人： BERNDL, Gunther , ROSENBERG, Joerg , SANNER, Axel
CPC分类号： A61K9/2095 , A61K9/1694 , A61K36/16 , A61K36/38 , A61K36/48 , A61K36/61 , A61K2300/00
摘要： The invention concerns solid active substance preparations containing as active substances plant extracts, with the exception of extracts of Gingko biloba, Glycyrrhiza glabra and Eucalyptus globulus. The preparations are obtained by extruding a mixture of at least one plant extract and at least one meltable polymer and subsequent shaping.
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公开(公告)号：EP1284716B1
公开(公告)日：2006-11-02
申请号：EP01957809.5
申请日：2001-05-29
发明人： BERNDL, Gunther , BREITENBACH, Jörg , HEGER, Robert , STADLER, Michael , WILKE, Peter , ROSENBERG, Jörg
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C47/0011 , B29C47/8895
摘要： The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.
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10.发明授权
公开(公告)号：EP1135109B1
公开(公告)日：2003-04-02
申请号：EP99966909.6
申请日：1999-11-30
发明人： BERNDL, Gunther , KOTHRADE, Stephan , KESSLER, Thomas , LANGE, Armin , HOFMANN, Jürgen , REINHOLD, Ulrich
IPC分类号： A61K9/16
CPC分类号： B29C47/42 , A61J3/10 , A61J2200/20 , A61K9/1694 , A61K9/2095 , B29B7/485 , B29C47/0021
摘要： The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).
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