公开(公告)号：EP4442700A1

公开(公告)日：2024-10-09

申请号：EP22900581.4

申请日：2022-12-01

Applicant: Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Inventor： HE, Hua ,  CHEN, Hao ,  ZHANG, Feiran ,  XU, Jiajia ,  ZHANG, Qiang ,  CAO, Xiaoli

IPC: C07K14/605 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38 ,  A61K47/18 ,  A61P3/10 ,  A61P3/04

CPC classification number: A61K38/26 ,  A61K47/26 ,  A61K47/38 ,  A61K47/18 ,  A61P3/04 ,  A61P3/10 ,  C07K14/605

Abstract: Provided are a pharmaceutical composition of GLP-1 and GIP receptor dual agonist and the use thereof. The pharmaceutical composition has good dissolution characteristics and stability.

公开(公告)号：EP4247334B1

公开(公告)日：2024-10-09

申请号：EP21815631.3

申请日：2021-11-17

IPC: A61K9/00 ,  A61K31/19 ,  A61K31/715 ,  A61K45/06 ,  A61P15/02 ,  A61P31/04 ,  A61P31/10

CPC classification number: A61K31/715 ,  A61K31/19 ,  A61P15/02 ,  A61P31/04 ,  A61P31/10 ,  A61K45/06 ,  A61K9/0034 ,  A61K9/06 ,  A61K47/38

公开(公告)号：EP4397659A3

公开(公告)日：2024-10-02

申请号：EP24171823.8

申请日：2015-04-24

Applicant: Chugai Seiyaku Kabushiki Kaisha

Inventor： TOMIMATSU, Takashi ,  OKAZAKI, Kensuke ,  OGAWA, Yumi ,  YAMAMURA, Takahiro

IPC: A61K31/5377 ,  A61K9/16 ,  A61K9/48 ,  A61K47/04 ,  A61K47/20 ,  A61K47/36 ,  A61K47/38 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D401/04

CPC classification number: A61K47/20 ,  A61K47/36 ,  A61K47/38 ,  A61K9/16 ,  A61K9/48 ,  A61K31/5377 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P43/00 ,  C07D401/04

Abstract: An improved solubility of a pharmaceutical composition or formulation containing a large amount of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile or a salt thereof can be achieved by forming granules of the compound or salt thereof and allowing the granules to be present together with a disintegrating agent.

公开(公告)号：EP4424302A1

公开(公告)日：2024-09-04

申请号：EP22903257.8

申请日：2022-11-29

Applicant: Chengdu Ruimu Biopharmaceuticals Co., Ltd.

Inventor： DONG, Qing ,  XUE, Lubing ,  TANG, Xin

IPC: A61K9/10 ,  A61K31/404 ,  A61K31/44 ,  A61K45/00 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/44 ,  A61P9/10 ,  A61P27/02 ,  A61P27/06

CPC classification number: A61P3/10 ,  A61K47/44 ,  A61K47/10 ,  A61K31/404 ,  A61K9/10 ,  A61P9/10 ,  A61K47/34 ,  A61K45/00 ,  A61K31/44 ,  A61K9/08 ,  A61P27/10 ,  A61K47/36 ,  A61K47/38 ,  A61P27/02 ,  A61P27/06

Abstract: An ophthalmic preparation of a tyrosine kinase inhibitor suitable for eye drop administration is prepared from the following active ingredients and adjuvants in parts by weight: active ingredient: 0.5-1.5 parts of tyrosine kinase inhibitor, wherein the content of the active ingredient in the ophthalmic preparation is 0.1-1 mg/mL; and pharmaceutically acceptable adjuvants: 200-300 parts of the surfactant, 0.5-7.0 parts of the tackifier, 10-800 parts of the solubilizer, with the balance being solvent. The ophthalmic preparation can effectively deliver the active ingredient to the fundus oculi to treat fundus angiogenesis diseases, with high absorption and utilization rate, small particle size and good stability, which are suitable for preparing sterile preparation by means of microporous filter membrane sterilization method and/or high-temperature sterilization method.

公开(公告)号：EP4415821A1

公开(公告)日：2024-08-21

申请号：EP22880543.8

申请日：2022-10-14

Applicant: TRIGONE PHARMA LTD.

Inventor： GORDON, Avigdor ,  MALCHI, Nadav ,  NASSER, Taher ,  TOUITOU, Dan

IPC: A61P13/00 ,  A61K47/10 ,  A61K47/32

CPC classification number: A61K47/10 ,  A61K47/32 ,  A61P13/00 ,  A61K9/0034 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/42 ,  A61K47/38 ,  A61K47/36 ,  A61K47/34 ,  A61K9/06

公开(公告)号：EP4408393A1

公开(公告)日：2024-08-07

申请号：EP22798287.3

申请日：2022-09-30

Applicant: Nutrition & Biosciences USA 1, LLC ,  Danisco Nutrition and Biosciences India Private Limited

Inventor： LOHADE, Atul Ashok Kumar ,  MULEY, Vinay ,  KHOT, Shrikant

IPC: A61K9/00 ,  A61K47/36 ,  A61K47/38 ,  A61K9/06 ,  A61K47/34

CPC classification number: A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61K47/38 ,  A61K47/34

公开(公告)号：EP4408183A1

公开(公告)日：2024-08-07

申请号：EP22790046.1

申请日：2022-09-29

Applicant: Nicoventures Trading Limited

Inventor： TANG, Kai ,  ALDERMAN, Steven Lee ,  POOLE, Thomas H. ,  ZAWADZKI, Michael

IPC: A23G4/00 ,  A24B15/16 ,  A61K9/00

CPC classification number: A24B15/16 ,  A61K9/0056 ,  A24B13/00 ,  A24B15/30 ,  A61K47/12 ,  A61K47/20 ,  A61K47/38 ,  A61K47/36 ,  A61K47/26 ,  A61K47/22 ,  A61K47/10 ,  A23G4/12 ,  A23G3/364

公开(公告)号：EP4406532A1

公开(公告)日：2024-07-31

申请号：EP24154169.7

申请日：2024-01-26

Applicant: Instituto Politécnico da Guarda

Inventor： Borges, Paula ,  Castro, Carla ,  Loureiro, Jorge ,  Miguel, Sónia ,  Jacinto, Telma ,  Moreira, André ,  Filipe, Hugo ,  Silva, Luís ,  Ribeiro, Maximiano ,  Saraiva, Sofia

IPC: A61K9/06 ,  A61K36/05 ,  A61K47/10 ,  A61K47/12 ,  A61K47/36 ,  A61K47/38 ,  A61P43/00 ,  A61K9/50

CPC classification number: A61K36/05 ,  A61K9/06 ,  A61K47/36 ,  A61K47/10 ,  A61K47/12 ,  A61P43/00 ,  A61K47/38 ,  A61K9/5036

Abstract: The present invention relates to a gel formulation for oral administration comprising microalgae biomass from Chlorella sorokiniana, Chlorella vulgaris or Tetradesmus obliquus, free or encapsulated in particles, suitable to adsorb different drugs in the gastrointestinal tract. It is also disclosed a process to obtain the gel formulation. The gel formulation is suitable for the treatment of drug intoxication in humans or animals, therefore finding application in pharmaceutical, medical and veterinary technical fields.

公开(公告)号：EP4404912A1

公开(公告)日：2024-07-31

申请号：EP22758432.3

申请日：2022-07-26

Applicant: Ferring B.V.

Inventor： VLASENKO, Iuliia Vasilyevna ,  MERKULOVA, Mariya Andreyevna

IPC: A61K9/00 ,  A61K38/04 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/38 ,  A61P25/00

CPC classification number: A61K38/04 ,  A61K9/0043 ,  A61K47/10 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/38 ,  A61K47/183 ,  A61K47/186 ,  A61P25/00

公开(公告)号：EP4403202A1

公开(公告)日：2024-07-24

申请号：EP22870036.5

申请日：2022-09-15

Applicant: Cosmed Pharmaceutical Co., Ltd.

Inventor： QUAN, Ying-shu ,  YAMASHITA, Hirofumi ,  KAJIYAMA, Kenji ,  LI, Ying-zhe ,  KAMIYAMA, Fumio

IPC: A61M37/00

CPC classification number: A61K9/70 ,  A61K47/32 ,  A61M37/00 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61L31/12 ,  A61L31/04 ,  A61L31/06 ,  A61L31/16

Abstract: To provide a practical microneedle preparation through finding an appropriate application condition regarding a geometric shape and a position on a needle of an applied material in a coated type microneedle. A microneedle array having a needle length of 350 um or more and 1,500 um or less and a diameter of a needle tip section apex of 15 um or more and 100 um or less, having a drug-applied portion, and comprising a non-biosoluble substance, preferably a non-biosoluble polymer, as a base, wherein no drug is applied to the needle tip section apex. It is preferable that the upper end of the drug-applied portion is a position 30 um or more lower than the needle tip section apex. The maximum diameter of the drug-applied portion is preferably 300 um or less.