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公开(公告)号：EP4298124A1
公开(公告)日：2024-01-03
申请号：EP22708900.0
申请日：2022-02-24
发明人： OBENDORF, Maik Stefan Wilhelm , SACHER, Frank , MÜLLER, Jörg , LESCHE, Ralf , VOTSMEIER, Christian , MÄRSCH, Stephan , TEBBE, Jan , ELLINGER, Philipp , SMITH, Patrick Michael , FITTING, Jenny , FILARSKY, Katharina , GEHRMANN, Mathias , KARLSTETTER, Marcus , WEBER, Ernst , TRAUTWEIN, Mark
IPC分类号： C07K16/24 , A61P15/00 , A61K39/395 , C07K16/28
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公开(公告)号：EP4298123A2
公开(公告)日：2024-01-03
申请号：EP22707724.5
申请日：2022-02-24
发明人： OBENDORF, Maik Stefan Wilhelm , SACHER, Frank , MÜLLER, Jörg , LESCHE, Ralf , VOTSMEIER, Christian , MÄRSCH, Stephan , TEBBE, Jan , ELLINGER, Philipp , SMITH, Patrick Michael , FITTING, Jenny , FILARSKY, Katharina , GEHRMANN, Mathias , KARLSTETTER, Marcus , WEBER, Ernst , TRAUTWEIN, Mark
IPC分类号： C07K16/24 , A61P15/00 , A61K39/395
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公开(公告)号：EP1283989A2
公开(公告)日：2003-02-19
申请号：EP01945050.1
申请日：2001-04-26
发明人： VÖLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/6893 , G01N33/6887 , G01N2333/47 , G01N2333/78 , G01N2333/8146 , G01N2333/96486 , G01N2800/085
摘要： The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
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公开(公告)号：EP1283989B1
公开(公告)日：2007-07-11
申请号：EP01945050.1
申请日：2001-04-26
发明人： VÖLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef
IPC分类号： G01N33/68 , G01N33/573
CPC分类号： G01N33/6893 , G01N33/6887 , G01N2333/47 , G01N2333/78 , G01N2333/8146 , G01N2333/96486 , G01N2800/085
摘要： The present invention concerns a method for diagnosing liver fibrosis wherein two or more diagnostic markers are measured and the measurements are correlated by a mathematic algorithm characterized in that the diagnostic markers are selected from the group N-terminal procollagen III propeptide (PIIINP), Collagen IV, Collagen VI, Tenascin, Laminin, Hyaluronan, MMP-2, TIMP-1 and MMP-9/TIMP-1 complex. The algorithm can be used to predict the histological score of a liver biopsy.
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