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公开(公告)号：EP4244225A1
公开(公告)日：2023-09-20
申请号：EP21830607.4
申请日：2021-11-09
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , MORTIER, Jeremie Xavier G. , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P35/02
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公开(公告)号：EP3700904A1
公开(公告)日：2020-09-02
申请号：EP18795421.9
申请日：2018-10-23
申请人： Bayer AG , BAYER PHARMA AKTIENGESELLSCHAFT , The Broad Institute, Inc. , Dana-Farber Cancer Institute Inc. et Al.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , KNUT, Eis , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , PETERSEN, Kirstin , MÖNNING, Ursula , EBERSPÄCHER, Uwe , MOOSMAYER, Dieter , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61P35/00 , A61K31/444 , A61K31/5377 , A61K31/4545
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公开(公告)号：EP3959211A1
公开(公告)日：2022-03-02
申请号：EP20721196.2
申请日：2020-04-22
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/4545 , A61P35/00
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公开(公告)号：EP4126861A1
公开(公告)日：2023-02-08
申请号：EP21715855.9
申请日：2021-03-25
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , MORTIER, Jeremie Xavier G. , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K31/341 , A61K31/337 , A61K31/357 , A61K31/351 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04
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公开(公告)号：EP3959212A1
公开(公告)日：2022-03-02
申请号：EP20721506.2
申请日：2020-04-22
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , GRADL, Stefan, Nikolaus , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61K31/4545 , A61P35/00
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公开(公告)号：EP3958865A1
公开(公告)日：2022-03-02
申请号：EP20721193.9
申请日：2020-04-22
发明人： SIEGEL, Franziska , KORR, Daniel , SCHRÖDER, Jens , SIEGEL, Stephan , GREULICH, Heidi , KAPLAN, Bethany , MEYERSON, Matthew
IPC分类号： A61K31/444 , A61K31/4545 , A61K31/5377 , A61K45/06 , A61P35/00 , G01N33/50 , C07D471/04
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公开(公告)号：EP3601253A1
公开(公告)日：2020-02-05
申请号：EP18712899.6
申请日：2018-03-22
发明人： LÜCKING, Ulrich , HOG, Daniel , CHRIST, Clara , SACK, Ulrike , SIEGEL, Franziska , LIENAU, Philip , WERBECK, Nicolas
IPC分类号： C07D401/12 , C07D239/30 , C07D498/04 , A61K31/519 , A61P9/00 , A61P35/00
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公开(公告)号：EP3601236A1
公开(公告)日：2020-02-05
申请号：EP18712892.1
申请日：2018-03-22
发明人： LÜCKING, Ulrich , HOG, Daniel , CHRIST, Clara , SACK, Ulrike , SIEGEL, Franziska , LIENAU, Philip , WERBECK, Nicolas
IPC分类号： C07D239/30 , C07D498/08 , C07D498/18 , C07D213/61 , A61K31/519 , A61P35/00 , A61P9/00
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9.发明公开3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开作为WNT信号通路抑制剂的3-氨基甲酰基苯基-4-甲酰胺和异鼠李素衍生物
公开(公告)号：EP3259263A1
公开(公告)日：2017-12-27
申请号：EP16704456.9
申请日：2016-02-16
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William j. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D401/14 , C07D213/73 , C07D213/75 , C07D401/12 , A61K31/435 , A61P35/00 , C07C15/04
CPC分类号： A61K31/435 , C07C237/44 , C07D213/73 , C07D213/75 , C07D401/12 , C07D401/14
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.
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公开(公告)号：EP3292107A1
公开(公告)日：2018-03-14
申请号：EP16721762.9
申请日：2016-05-02
发明人： EIS, Knut , ACKERSTAFF, Jens , WAGNER, Sarah , BUCHGRABER, Philipp , SÜLZLE, Detlev , HOLTON, Simon , BENDER, Eckhard , LI, Volkhart , LIU, Ningshu , SIEGEL, Franziska , LIENAU, Philip , BAIRLEIN, Michaela , VON NUSSBAUM, Franz , HERBERT,Simon , KOPPITZ, Marcus
IPC分类号： C07D233/54 , C07D263/34 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/14 , A61K31/38 , A61K31/4164 , A61K31/421 , A61K31/5025 , A61P35/00
CPC分类号： C07D233/90 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/554 , A61K45/06 , A61P35/00 , A61P35/04 , C07D233/54 , C07D263/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
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