Abstract:
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Abstract:
A pyridine compound having a SF 5 group on position-3 and position-4 of a pyridine ring is provided. Pentafluorosulfanyl pyridine represented by formula (d):
wherein a SF 5 group binds to either one of position-3 or position-4 of a pyridine ring, and R 2 binds to the other one of position-3 or position-4; and R 1 , R 2 , R 3 , and R 4 are independently a hydrogen atom, a halogen atom, a substituted or non-substituted alkyl group having 1 to 18 carbon atoms, a substituted or non-substituted aryl group having 6 to 30 carbon atoms, a nitro group, a cyano group, a substituted or non-substituted alkanesulfonyl group having 1 to 18 carbon atoms, a substituted or non-substituted arenesulfonyl group having 6 to 30 carbon atoms, a substituted or non-substituted alkoxy group having 1 to 18 carbon atoms, a substituted or non-substituted aryloxy group having 6 to 30 carbon atoms, an acyloxy group having 1 to 18 carbon atoms, a substituted or non-substituted alkanesulfonyloxy group having 1 to 18 carbon atoms, a substituted or non-substituted arenesulfonyloxy group having 6 to 30 carbon atoms, a substituted or non-substituted alkoxycarbonyl group having 2 to 18 carbon atoms, a substituted or non-substituted aryloxycarbonyl group having 7 to 30 carbon atoms, a substituted carbamoyl group having 2 to 18 carbon atoms, a substituted amino group having 1 to 18 carbon atoms, an amino group, an azide group, a substituted or non-substituted aralkyloxy group having 7 to 30 carbon atoms, a substituted or non-substituted aralkylsulfide group having 7 to 30 carbon atoms, or a SF 5 group.
Abstract:
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
Abstract:
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
Abstract:
The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
Abstract:
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Abstract:
The present invention relates to use of inhibitors of Notch signaling pathway selected from the group consisting of 6-4[-(tertbutyl)-phenoxy] pyridine-3-amine (13), Cyclopiazinic acid and Lasatocid in treating and/or preventing cancers.
Abstract:
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.