公开(公告)号：EP1957515A2

公开(公告)日：2008-08-20

申请号：EP06829357.0

申请日：2006-11-27

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： MÜLLER, Gerd ,  KOSEMUND, Dirk ,  WYRWA, Ralf

IPC分类号： C07J41/00 ,  A61K31/565 ,  A61P5/28 ,  A61P5/32 ,  A61P15/00 ,  A61P19/10

CPC分类号： C07J41/0033

摘要： The invention relates to a prodrugs of 9α-substituted estratrienes of general formula (I), wherein the Z group is linked to a steroid, (I). The invention also relates to a methods for the production thereof, pharmaceutical compositions which contain said compounds, and to the use thereof. Said inventive compounds of general formula (I) do not bond with the oestrogen receptor alpha and/ or beta but they bond with carboanhydrases and inhibitors of said enzymes.

公开(公告)号：EP2200962A1

公开(公告)日：2010-06-30

申请号：EP08837938.3

申请日：2008-10-10

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： WYRWA, Ralf ,  PETERS, Olaf ,  BOHLMANN, Rolf ,  DROESCHER, Peter ,  PRELLE, Katja ,  FRITZEMEIER, Karl-Heinrich ,  MUHN, Hans-Peter

IPC分类号： C07C39/14 ,  C07C39/23 ,  C07C39/42 ,  A61K31/05 ,  A61K31/055 ,  A61P5/30 ,  A61P15/00

CPC分类号： C07C39/23 ,  C07C39/17 ,  C07C43/23 ,  C07D333/16

摘要： The present invention describes non-steroidal compounds of the general Formula (I) in which A is Formula (II) in which X1 means one or more groups on the phenyl rinq and represents independently of one another a halogen, OH, (C1-C4)aIkyl, (C1-C4)alkyl-O, (C3-C6)cycloalkyl-O, (C1-C14)acyl-O, (C1C4)alkenyl, (C1-C4)alkynyl, perfluoro(C1C4)alkyl radical, -CHO or CN, and X2 means one or more groups on the phenyl ring and represents independently of one another an H, halogen, OH, (C1C4)alkyl, (C1C4)alkyl-O, (C1-C4)Jalkenyl, (C1-C4)alkynyl, perfluoro- (C1C4)alkyl radical, -CHO or CN, as Estrogens.

公开(公告)号：EP1957513A2

公开(公告)日：2008-08-20

申请号：EP06829354.7

申请日：2006-11-27

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： WYRWA, Ralf ,  NUBBEMEYER, Reinhard ,  GANZER, Ursula

IPC分类号： C07J41/00 ,  A61K31/565 ,  A61P5/26 ,  A61P5/30

CPC分类号： C07J41/0072 ,  C07J41/0038

摘要： The invention relates to the sulfamoyl sulfonate prodrugs of general formula (I), to a method for producing them, to pharmaceutical compositions containing the same and to their use for producing orally available drugs. The compounds according to the invention bind to carboanhydrases and inhibit these enzymes.

摘要翻译： 本发明涉及通式（I）的氨磺酰基磺酸盐前药，它们的制备方法，含有其的药物组合物及其用于生产口服药物的用途。 根据本发明的化合物结合碳水化合物酶并抑制这些酶。

公开(公告)号：EP1957514A1

公开(公告)日：2008-08-20

申请号：EP06829356.2

申请日：2006-11-27

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： PETERS, Olaf ,  REDDERSEN, Gudrun ,  WYRWA, Ralf ,  HILLISCH, Alexander ,  ELGER, Walter ,  PRELLE, Katja ,  DROESCHER, Peter

IPC分类号： C07J41/00 ,  A61K31/565 ,  A61P5/30

CPC分类号： C07J41/0072

摘要： The invention relates to prodrugs of 8-β-substituted estratrienes of general formula (I) in which the Z group is bonded to the steroid, method for production thereof, pharmaceutical compositions comprising said compounds and use thereof. Said compounds of general formula (I) do not bind to α- and/or β- estrogen receptors, but to carboanhydrases and inhibit said enzymes.