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公开(公告)号：EP1912970A2
公开(公告)日：2008-04-23
申请号：EP06776768.1
申请日：2006-08-08
发明人： WORTMANN, Lars , CLEVE, Arwed , MUHN, Hans-Peter , LANGER, Gernot , SCHREY, Anna , KÜHNE, Ronald , MENZENBACH, Bernd , KOPPITZ, Marcus , KOSEMUND, Dirk
IPC分类号： C07D401/12 , C07D405/14 , C07D209/14 , C07D405/12 , C07D409/12 , C07D417/14 , C07D403/12 , C07D413/12 , C07D215/52 , C07D405/04 , C07D307/79 , C07D333/32 , C07D215/50 , C07D417/04 , C07D317/60
CPC分类号： C07D413/12 , C07C65/24 , C07D209/14 , C07D213/79 , C07D215/50 , C07D215/52 , C07D235/06 , C07D239/28 , C07D239/74 , C07D277/56 , C07D307/79 , C07D317/60 , C07D333/32 , C07D333/38 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/04 , C07D417/14
摘要： The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译： 本专利申请涉及通式I的酰基色氨酸，其中Q，X，Y，W，R 1，R 2，R 3，R 4，R 5，R 8具有说明书中所述的含义。 本发明化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。
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2.发明公开NEW THIAZOLIDINONES WITHOUT BASIC NITROGEN, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS 审中-公开新型无噻唑烷酮盐基氮，生产与应用，药物活性成分
公开(公告)号：EP1877406A1
公开(公告)日：2008-01-16
申请号：EP06753498.2
申请日：2006-04-24
发明人： PRIEN, Olaf , SCHULZE, Volker , EIS, Knut , WORTMANN, Lars , KOSEMUND, Dirk , SIEMEISTER, Gerhard , EBERSPAECHER, Uwe , GUENTHER, Judith , BRITTAIN, Dominic E., A.
IPC分类号： C07D417/06 , C07D277/34 , A61K31/427 , A61P35/00 , A61P37/00
CPC分类号： C07D277/34 , C07D417/06
摘要： The invention relates to thiazolidinones of general formula (I): as well as to their production and to their use as inhibitors of the polo-like kinase (PIk) for treating various diseases, as well as to intermediate products for the production of the compounds according to the invention.
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3.发明公开THIAZOLIDINONE ALS INHIBITOREN DER POLO LIKE KINASE (PLK) ALS ARZNEIMITTEL 审中-公开噻唑啉AS AS药物POLO样激酶（PLK）的抑制剂
公开(公告)号：EP1844027A1
公开(公告)日：2007-10-17
申请号：EP06706691.0
申请日：2006-02-02
发明人： SCHULZE, Volker , EIS, Knut , WORTMANN, Lars , KOSEMUND, Dirk , PRIEN, Olaf , SIEMEISTER, Gerhard , HESS-STUMPP, Holger , EBERSPAECHER, Uwe , ARNAIZ, Damian O.
IPC分类号： C07D277/14 , C07D417/12 , C07D417/06 , C07D417/14 , A61K31/435 , A61K31/41 , A61P35/00
CPC分类号： C07D277/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to the thiazolidinones of general formula (I), to the production and use thereof as inhibitors of Polo-like kinase (Plk) for use in the treatment of various diseases.
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公开(公告)号：EP2001846A1
公开(公告)日：2008-12-17
申请号：EP07723650.3
申请日：2007-03-22
IPC分类号： C07D209/42 , C07D405/12 , A61K31/40 , A61K31/535 , A61P15/00
CPC分类号： C07D405/12 , C07D209/42
摘要： The invention relates to compounds of the general formula (I) and to their preparation and use as a medicament.
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5.发明公开SULFONSUBSTITUIERTE CHINAZOLINDERIVATIVE ALS IMMUNMODULATOREN ZUR BEHANDLUNG VON ENZÜNDLICHEN UND ALLERGISCHEN ERKRANKUNGEN 有权SULFONSUBSTITUIERTE CHINAZOLINDERIVATIVE作为免疫调节剂用于治疗ENZÜNDLICHEN和过敏性疾病
公开(公告)号：EP2321284A1
公开(公告)日：2011-05-18
申请号：EP09800010.2
申请日：2009-07-18
发明人： BUCHMANN, Bernd , KOSEMUND, Dirk , NGUYEN, Duy , VON BONIN, Arne
IPC分类号： C07D239/94 , A61K31/517 , A61P37/02 , A61P37/08
CPC分类号： C07D239/94
摘要： The present invention relates to sulfone substituted quinazoline derivatives of the formula (1), a method for the production thereof, and the use as a medicine for the treatment of various diseases associated with inflammatory, allergic, and/or proliferative processes.
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公开(公告)号：EP2001843A2
公开(公告)日：2008-12-17
申请号：EP07723652.9
申请日：2007-03-22
IPC分类号： C07D209/04 , C07D209/42 , C07D405/12 , A61K31/5377 , A61P15/16
CPC分类号： C07D405/12 , C07D209/04 , C07D209/42
摘要： The invention relates to compounds of general formula (I), to their production and to their use as a medicament.
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公开(公告)号：EP1365768B1
公开(公告)日：2008-05-07
申请号：EP02706750.3
申请日：2002-02-27
发明人： HEGELE-HARTUNG, Christa , FRITZEMEIER, Karl-Heinrich , YAMANOUCHI, Hiroshi , PETERS, Olaf , KOSEMUND, Dirk , MUELLER, Gerd , TORNUS, Ingo , SCHUBERT, Gerd , RING, Sven
IPC分类号： A61K31/57 , A61K31/565 , A61K31/00 , C07J63/00
CPC分类号： A61K31/00 , A61K31/05 , A61K31/122 , A61K45/06
摘要： The present invention discloses the use of ERSS-selective ligands for production of medicaments for regulating fertility without additional use of a progestin. ERSS-agonists are used for treatment of infertility and ERSS-antagonists for contraception.
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8.发明公开PRODRUGS ERbeta-SELEKTIVER SUBSTANZEN, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 审中-公开前体药物ERbeta选择性的物质，方法及其他们和药物组合物含
公开(公告)号：EP1957515A2
公开(公告)日：2008-08-20
申请号：EP06829357.0
申请日：2006-11-27
发明人： MÜLLER, Gerd , KOSEMUND, Dirk , WYRWA, Ralf
CPC分类号： C07J41/0033
摘要： The invention relates to a prodrugs of 9α-substituted estratrienes of general formula (I), wherein the Z group is linked to a steroid, (I). The invention also relates to a methods for the production thereof, pharmaceutical compositions which contain said compounds, and to the use thereof. Said inventive compounds of general formula (I) do not bond with the oestrogen receptor alpha and/ or beta but they bond with carboanhydrases and inhibitors of said enzymes.
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9.发明公开METASUBSTITUIERTE THIAZOLIDINONE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 审中-公开间位取代的噻唑烷酮，生产和使用AS DRUGS
公开(公告)号：EP1824834A1
公开(公告)日：2007-08-29
申请号：EP05813723.3
申请日：2005-12-12
发明人： SCHULZE, Volker, Klaus , EIS, Knut , WORTMANN, Lars , KOSEMUND, Dirk , PRIEN, Olaf , SIEMEISTER, Gerhard , HESS-STUMPP, Holger , EBERSPÄCHER, Uwe , ISLAM, Imadul
IPC分类号： C07D277/20 , C07D417/12 , A61K31/427 , A61K31/426
CPC分类号： C07D277/14 , C07D277/20 , C07D417/12 , C07D417/14
摘要： The invention relates to thiazolidinones of general formula (I), to the production thereof and to their use as inhibitors of the polo-like kinase (Plk) for treating different diseases.
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