公开(公告)号：EP1210425B1

公开(公告)日：2007-04-25

申请号：EP00957502.8

申请日：2000-08-16

申请人： Biogen Idec MA Inc. ,  Apotech R&D S.A.

发明人： MACKAY, Fabienne ,  BROWNING, Jeffrey ,  AMBROSE, Christine ,  TSCHOPP, Jurg ,  SCHNEIDER, Pascal ,  THOMPSON, Jeffrey

IPC分类号： C12N15/12 ,  C07K14/715 ,  A61K38/17 ,  A61K39/395

CPC分类号： C07K14/7151 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  C07K2319/00

摘要： Receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.

公开(公告)号：EP1210425B2

公开(公告)日：2015-06-17

申请号：EP00957502.8

申请日：2000-08-16

申请人： Biogen MA Inc. ,  Apotech R&D S.A.

发明人： MACKAY, Fabienne ,  BROWNING, Jeffrey ,  AMBROSE, Christine ,  TSCHOPP, Jurg ,  SCHNEIDER, Pascal ,  THOMPSON, Jeffrey

IPC分类号： C12N15/12 ,  C07K14/715 ,  A61K38/17 ,  A61K39/395

CPC分类号： C07K14/7151 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  C07K2319/00

公开(公告)号：EP2073833A2

公开(公告)日：2009-07-01

申请号：EP07868490.9

申请日：2007-10-18

申请人： Biogen Idec MA Inc. ,  UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： BROWNING, Jeffrey ,  TING, Jenny P-y.

IPC分类号： A61K38/17 ,  A61M3/00 ,  A61K39/395 ,  A61P25/00

CPC分类号： A61K38/1793 ,  C07K14/70578 ,  C07K2319/30

摘要： The invention relates to the treatment of demyelinating disorders, e.g. multiple sclerosis, using a soluble lymphotoxin beta receptor (LTβR) as an inhibitor of the lymphotoxin pathway.

公开(公告)号：EP0954333B1

公开(公告)日：2006-06-28

申请号：EP97913798.1

申请日：1997-10-24

申请人： Biogen Idec MA Inc.

发明人： BROWNING, Jeffrey ,  HOCHMAN, Paula, Susan ,  RENNERT, Paul, D. ,  MacKAY, Fabienne

IPC分类号： A61K39/395 ,  A61K38/17 ,  A61K38/55 ,  C07K19/00

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7151 ,  C07K16/241 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30 ,  Y02A50/401 ,  Y02A50/414

摘要： Compositions and methods comprising "lymphotoxin- beta receptor blocking agents" which block lymphotoxin-ss receptor signalling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.

公开(公告)号：EP1210425A2

公开(公告)日：2002-06-05

申请号：EP00957502.8

申请日：2000-08-16

申请人： BIOGEN, INC. ,  Apotech R&D S.A.

发明人： MACKAY, Fabienne ,  BROWNING, Jeffrey ,  AMBROSE, Christine ,  TSCHOPP, Jurg ,  SCHNEIDER, Pascal ,  THOMPSON, Jeffrey

IPC分类号： C12N15/12 ,  C07K14/715 ,  A61K38/17 ,  A61K39/395

CPC分类号： C07K14/7151 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  C07K2319/00

摘要： Receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.

公开(公告)号：EP1317283B1

公开(公告)日：2011-07-06

申请号：EP01968799.5

申请日：2001-09-12

申请人： Biogen Idec MA Inc.

发明人： BROWNING, Jeffrey ,  BURKLY, Linda ,  JAKUBOWSKI, Aniela ,  ZHENG, Timothy

IPC分类号： A61K39/395 ,  A61K38/17 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/73

摘要： The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.

公开(公告)号：EP1141248B1

公开(公告)日：2011-12-07

申请号：EP99967350.2

申请日：1999-12-16

申请人： Biogen Idec MA Inc.

发明人： BROWNING, Jeffrey ,  MIATKOWSKI, Konrad ,  MEIER, Werner

IPC分类号： C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  A61K38/17

CPC分类号： C12P21/00 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00 ,  C12P21/02

摘要： The invention relates to methods for the expression of high yields of the form protein-immunoglobulin fusions having high affinity binding to its ligand, by culturing hosts transformed with DNA encoding the desired fusions in a cultutre system at a low temperature thereby minimizing the amount of misfolded or misbridged protein forms. Said host cells may be transformed mammalian, insect, yeast or bacterial cells. The protein-immunoglobulin fusion may comprises a member of the TNF or TNF-receptor family, such as lymphotoxin-beta or lymphotoxin-beta receptor. The invention also relates to pharmaceutical composition comprising said protein-immunoglobulin fusions.

公开(公告)号：EP0672143B1

公开(公告)日：2008-06-04

申请号：EP94907045.2

申请日：1993-12-02

申请人： Biogen Idec MA Inc. ,  The Regents of the University of California

发明人： BROWNING, Jeffrey ,  WARE, Carl F.

IPC分类号： C12N15/19 ,  C12P21/02 ,  C07K14/00 ,  A61K38/00 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/525 ,  A61K38/00

摘要： This invention relates to lymphotoxin- beta , a lymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. This invention also relates to complexes formed between lymphotoxin- beta and other peptides such as lymphotoxin- alpha and to complexes comprising multiple subunits of lymphotoxin- beta . These proteins and complexes are useful in holding LT- alpha formed within the cell on the cell surface where the LT- alpha /LT- beta complex may act as an inflammation regulating agent, a tumor growth inhibiting agent, a T cell inhibiting agent, a T cell activating agent, an autoimmune disease regulating agent, or an HIV inhibiting agent. Furthermore, the antitumor activity of the LT- alpha /LT- beta complex may be delivered to tumor cells by tumor infiltrating lymphocytes (TILs) transfected with the gene for LT- beta .