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公开(公告)号:EP2314694A2
公开(公告)日:2011-04-27
申请号:EP10181130.5
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: C12N15/12 , C07K14/715 , A61K38/17 , A61K39/395
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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公开(公告)号:EP2324844A3
公开(公告)日:2013-12-11
申请号:EP10181119.8
申请日:2000-10-05
IPC分类号: A61K38/17 , A61K39/395
CPC分类号: C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要: A receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
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公开(公告)号:EP2324844A2
公开(公告)日:2011-05-25
申请号:EP10181119.8
申请日:2000-10-05
IPC分类号: A61K38/17 , A61K39/395
CPC分类号: C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要: A receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的受体:APRIL-R。 还提供了嵌合分子和对APRIL-R的抗体及其使用方法。
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公开(公告)号:EP2314694A3
公开(公告)日:2013-12-11
申请号:EP10181130.5
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: C12N15/12 , C07K14/715 , A61K38/17 , A61K39/395
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
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公开(公告)号:EP1847273A1
公开(公告)日:2007-10-24
申请号:EP07106184.0
申请日:2000-10-05
CPC分类号: C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要: A receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的受体:APRIL-R。 还提供了嵌合分子和对APRIL-R的抗体及其使用方法。
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公开(公告)号:EP1806143A2
公开(公告)日:2007-07-11
申请号:EP07100908.8
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: A61K38/17 , A61K39/395 , A61P37/00 , A61P9/12 , A61P13/12
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R, Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的受体:还提供了BAFF-R,嵌合分子和对BAFF-R的抗体及其使用方法。
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公开(公告)号:EP1746106A2
公开(公告)日:2007-01-24
申请号:EP06118875.1
申请日:2001-04-27
申请人: Biogen Idec MA Inc. , Apoxis SA
IPC分类号: C07K14/705 , C12N15/12 , C12N15/62 , C07K19/00 , A61P35/00
CPC分类号: C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: A method of treating a mammal for a condition associated with undesired cell proliferation comprising administering to said mammal an effective amount an effective amount of a TACI reagent, wherein said reagent extends mean survival time of said mammal by about 10 % or more as compared to the absence of administering the TACI reagent.
摘要翻译: 一种治疗哺乳动物与不期望的细胞增殖相关的病症的方法,包括向所述哺乳动物施用有效量的有效量的TACI试剂,其中所述试剂将所述哺乳动物的平均存活时间延长约10%或更多,与 不服用TACI试剂。
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公开(公告)号:EP1806143A3
公开(公告)日:2007-07-18
申请号:EP07100908.8
申请日:2000-08-16
发明人: Mackay, Fabienne , Browning, Jeffrey , Ambrose, Christine , Tschopp, Jurg , Schneider, Pascal , Thompson, Jeffrey
IPC分类号: A61K38/17 , A61K39/395 , A61P37/00 , A61P9/12 , A61P13/12
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A receptor in the TNF family is provided: BAFF-R, Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供了TNF家族中的受体:还提供了BAFF-R,嵌合分子和抗BAFF-R的抗体及其使用方法。
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公开(公告)号:EP2325317A1
公开(公告)日:2011-05-25
申请号:EP10180786.5
申请日:2001-09-06
申请人: Biogen Idec MA Inc.
IPC分类号: C12N15/12 , C12N15/62 , C12N15/10 , C12N5/10 , C12P21/02 , C07K14/715 , C07K16/28 , C07H21/04 , C12Q1/68 , A61K38/17 , A61K48/00 , G01N33/53 , G01N33/68
CPC分类号: C07K14/70578 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/7151 , C07K16/2866 , C07K16/2878 , C07K2319/00 , Y02A50/414
摘要: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.
摘要翻译: 公开了编码BAFF-R多肽的核酸,以及对BAFF-R多肽的抗体和包含其的药物组合物。 还提供了使用本发明的核酸,多肽,抗体和药物组合物治疗致瘤和自身免疫病症的方法。
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公开(公告)号:EP1746106A3
公开(公告)日:2007-03-14
申请号:EP06118875.1
申请日:2001-04-27
申请人: Biogen Idec MA Inc. , Apoxis SA
IPC分类号: C07K14/705 , C12N15/12 , C12N15/62 , C07K19/00 , A61P35/00
CPC分类号: C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: A method of treating a mammal for a condition associated with undesired cell proliferation comprising administering to said mammal an effective amount an effective amount of a TACI reagent, wherein said reagent extends mean survival time of said mammal by about 10 % or more as compared to the absence of administering the TACI reagent.
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