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1.发明公开NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812A1
公开(公告)日：2006-12-06
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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2.发明授权NEUE CYCLOALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权NEW环烷基含有5-ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727812B1
公开(公告)日：2008-12-31
申请号：EP05715812.3
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D401/12 , C07D209/34 , C07D451/14 , C07D403/12 , C07D409/14
CPC分类号： C07D209/34 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/14 , C07D451/14
摘要： The invention relates to cycloalkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claims 1 to 6, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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3.发明授权NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799B1
公开(公告)日：2009-01-07
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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4.发明公开
公开(公告)号：EP1737839A1
公开(公告)日：2007-01-03
申请号：EP05739806.7
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , LUSTENBERGER, Philipp , THOMAS, Leo , SCHINDLER, Marcus , ROTH, Gerald Jürgen , RUDOLF, Klaus , LOTZ, Ralf R. H.
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , A61K31/4709 , A61K31/4427 , A61P3/04
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14
摘要： The invention relates to alkyne compounds of general formula (I), in which groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings cited in Claim 1. The invention also relates to medicaments containing at least one inventive alkyne. The MCH receptor antagonistic effect renders the inventive medicaments suitable for treating metabolic disorders and/or eating disorders, in particular, obesity and diabetes.
摘要翻译： 本发明涉及通式（I）的炔化合物，其中基团和残基A，B，W，X，Y，Z，R 1和R 2具有权利要求1中引用的含义。本发明还涉及药物，其至少含有 一个本发明的炔烃。 MCH受体拮抗作用使得本发明的药物适用于治疗代谢紊乱和/或进食障碍，特别是肥胖和糖尿病。
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5.发明公开NEUE ALKIN-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 审中-公开新ALKIN CONNECTIONS MCH拮抗作用及药物含有它们的
公开(公告)号：EP1742939A2
公开(公告)日：2007-01-17
申请号：EP05729108.0
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , ROTH, Gerald Jürgen , RUDOLF, Klaus , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D405/14 , A61K31/4433 , A61P3/04
CPC分类号： C07D471/08 , C07D405/06 , C07D405/14
摘要： The invention relates to an alkyne compound of general formula (I) in which A, B, W, X, Y, Z, R1 and R2 groups and residuals have the meanings given in claim 1. Drugs containing at least one type of inventive alkyne are also disclosed. The inventive drugs exhibiting an MCH-receptor antagonistic activity are suitable for treating metabolic disturbances and/or eating disorders, in particular adiposity, bulimia, anorexia, hyperphagia and diabetes.
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6.发明公开
公开(公告)号：EP1740572A1
公开(公告)日：2007-01-10
申请号：EP05716558.1
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , THOMAS, Leo , SCHINDLER, Marcus , ROTH, Gerald Jürgen , RUDOLF, Klaus , LOTZ, Ralf R. H.
IPC分类号： C07D401/12 , A61P3/04 , C07D213/30 , C07D405/12 , C07D409/14 , C07D213/61 , A61K31/4439
CPC分类号： C07D401/14 , C07D213/30 , C07D213/38 , C07D213/61 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/14
摘要： The invention relates to alkyne compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1 and R2 are defined as cited in claim 1. The invention also relates to medicaments containing at least one inventive alkyne. As a result of the antagonistic action against the MCH-receptor, the inventive medicaments are suitable for treating metabolic disorders and/or eating disorders, in particular adiposity and diabetes.
摘要翻译： 本发明涉及通式（I）的炔化合物，其中基团A和基团A，B，W，X，Y，Z，R 1和R 2如权利要求1中所定义。本发明还涉及药物， 至少一种本发明的炔烃。 由于对MCH受体的拮抗作用，本发明药物适用于治疗代谢障碍和/或进食障碍，特别是肥胖症和糖尿病。
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7.发明公开NEUE ALKYL-HALTIGE 5-ACYLINDOLINONE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权新的含烷基5 ACYLINDOLINONE，其制备及其作为药物
公开(公告)号：EP1727799A1
公开(公告)日：2006-12-06
申请号：EP05715811.5
申请日：2005-03-05
发明人： HECKEL, Armin , ROTH, Gerald Jürgen , KLEY, Jörg , HOERER, Stefan , UPHUES, Ingo
IPC分类号： C07D209/34 , C07D401/12 , C07D405/06 , C07D405/14 , C07D403/06 , C07D401/06 , A61K31/501 , A61P25/28
CPC分类号： C07D401/06 , C07D209/34 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/14
摘要： The invention relates to alkyl-containing 5-acylindolinones of the general formula (I), where R1 to R3 are as defined in claim 1, and to tautomers, enantiomers, diastereomers, mixtures and salts thereof with valuable pharmacological properties, more particularly an inhibitory effect on protein kinases, more particularly an inhibitory effect on the activity of glycogen synthase kinase (GSK-3).
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