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公开(公告)号：EP2029234A1
公开(公告)日：2009-03-04
申请号：EP07729918.8
申请日：2007-06-06
发明人： DOODS, Henri , ARNDT, Kirsten , BOUYSSOU, Thierry , MUELLER, Stephan Georg , RUDOLF, Klaus , SCHAENZLE, Gerhard
IPC分类号： A61P29/00 , A61P1/04 , A61P1/06 , A61P1/14 , A61P1/00 , A61K31/517 , A61K31/551
CPC分类号： A61K31/551 , A61K31/517
摘要： The invention relates to a method for preventing and treating visceral pain and gastrointestinal disorders such as functional bowel disorders and inflammatory bowel diseases through the use of effective amounts of a compound acting as CGRP antagonist.
摘要翻译： 本发明涉及通过使用有效量的充当CGRP拮抗剂的化合物预防和治疗内脏疼痛和胃肠病症例如功能性肠病症和炎性肠病的方法。
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2.发明公开(HETERO)ARYL COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 审中-公开（杂）与MCH拮抗作用和芳基化合物药物同这些链接
公开(公告)号：EP1943231A1
公开(公告)日：2008-07-16
申请号：EP06807530.8
申请日：2006-10-25
发明人： ROTH, Gerald Juergen , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , STENKAMP, Dirk , LUSTENBERGER, Philipp , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D237/08 , A61K31/501 , A61P3/04
CPC分类号： C07D237/08
摘要： The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
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3.发明公开2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-YL-PIPERIDINE ALS CGRP-ANTAGONISTEN 有权2-氧代-1,2,4,5-四氢-1,3-苯并二氮杂-3-基 - 哌啶ALS CGRP拮抗剂
公开(公告)号：EP1863791A1
公开(公告)日：2007-12-12
申请号：EP06723571.3
申请日：2006-03-21
发明人： MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , SANTAGOSTINO, Marco , PALEARI, Fabio , DREYER, Alexander , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/04 , C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to novel CGRP antagonists of general formula (I), in which B, R1 and R2 are defined as cited in claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts, in addition to the hydrates of their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases. The invention also relates to medicaments containing said compounds, to their use and to a method for their production.
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4.发明公开
公开(公告)号：EP1747208A1
公开(公告)日：2007-01-31
申请号：EP05740022.8
申请日：2005-05-10
发明人： BOUYSSOU, Thierry , SCHNAPP, Andreas , LUSTENBERGER, Philipp , RUDOLF, Klaus , PIEPER, Michael, P. , GRAUERT, Matthias , BREITFELDER, Steffen , SPECK, Georg
IPC分类号： C07D265/36 , C07D471/08 , A61K31/538 , A61P11/00
CPC分类号： C07D265/36 , C07D471/08
摘要： The invention relates to the compounds of general formula (1), wherein the groups n, A, B, D, L, R1, R2, R3 and R4 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of respiratory diseases.
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5.发明公开AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 有权AUSGEWÄHLTECGRP-ANTAGONISTEN，VERFAHREN ZU德仁HERSTELLUNG SOWIE德仁VERWENDUNG ALS医药有限公司
公开(公告)号：EP1737842A1
公开(公告)日：2007-01-03
申请号：EP05731650.7
申请日：2005-04-09
发明人： MUELLER, Stephan Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/14 , C07D471/10 , C07D513/04 , C07D453/04 , C07D401/04 , C07D451/04 , C07D471/04 , C07D495/04 , C07D487/08 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04 , C07D451/04 , C07D453/02 , C07D487/04 , C07D487/08
摘要： The invention relates to the CGRP antagonists of general formula (I), wherein A, X and R1 to R3 are defined as in claim 1. The invention also relates to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and to the hydrates of said salts, especially their physiologically acceptable salts with inorganic or organic acids, to drugs comprising said compounds, to their use and to a method for producing the same.
摘要翻译： 本发明涉及通式（I）的CGRP拮抗剂，其中A，X和R 1 -R 3如权利要求1中所定义。本发明还涉及其互变异构体，非对映异构体，对映异构体，水合物，混合物和盐以及 所述盐的水合物，特别是其与无机酸或有机酸的生理学上可接受的盐，包含所述化合物的药物，它们的用途及其制备方法。
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6.发明公开
公开(公告)号：EP1737823A2
公开(公告)日：2007-01-03
申请号：EP05737015.7
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan, Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , ROTH, Gerald, Jürgen , RUDOLF, Klaus , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf, R., H.
IPC分类号： C07D213/00
CPC分类号： C07D213/30 , C07D213/38 , C07D213/74 , C07D213/75 , C07D401/06 , C07D401/10 , C07D401/12 , C07D409/10 , C07D409/14 , C07D451/06
摘要： The invention relates to individual alkyne compounds with an antagonistic action against the MCH-receptor. Said compounds are suitable for producing medicaments for the treatment of metabolic disorders and/or eating disorders, in particular adiposity and diabetes.
摘要翻译： 本发明涉及对MCH受体具有拮抗作用的单独的炔烃化合物。 所述化合物适用于生产用于治疗代谢紊乱和/或进食障碍，特别是肥胖症和糖尿病的药物。
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7.发明授权NEW PYRIDONE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS 有权与MCH拮抗作用及药物的新吡啶酮衍生物，这些化合物
公开(公告)号：EP2069327B1
公开(公告)日：2013-10-16
申请号：EP07819958.5
申请日：2007-08-20
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LEHMANN-LINTZ, Thorsten , ROTH, Gerald Juergen , KLEY, Joerg , RUDOLF, Klaus , HECKEL, Armin , SCHINDLER, Marcus , LOTZ, Ralf
IPC分类号： C07D401/10 , C07D403/10 , C07D403/14 , C07D405/12 , C07D409/14 , C07D417/06 , A61K31/435 , A61K31/495
CPC分类号： C07D401/14 , C07D213/63 , C07D213/69 , C07D213/74 , C07D237/14 , C07D237/16 , C07D239/52 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/14 , C07D409/14 , C07D417/12 , C07D451/06 , C07D471/04 , C07D513/04
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公开(公告)号：EP1765355B1
公开(公告)日：2013-03-06
申请号：EP05740045.9
申请日：2005-04-18
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , SCHROMM, Kurt , BUETTNER, Frank , HEINE, Claudia , SCHOLLENBERGER, Hermann
IPC分类号： A61K31/538 , A61P11/06
CPC分类号： A61K31/538
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9.发明授权
公开(公告)号：EP1761509B1
公开(公告)日：2011-05-04
申请号：EP05747842.2
申请日：2005-05-10
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , SANTAGOSTINO, Marco
IPC分类号： C07D265/28 , A61K31/538 , C07C215/30 , A61P11/00
CPC分类号： C07D265/28
摘要： The invention relates to the compounds of formula (1), wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X are defined as in the claims and in the description. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of inflammatory and obstructive respiratory diseases.
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10.发明授权AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 有权SELECTED CGRP拮抗剂，它们的生产方法及其作为药物
公开(公告)号：EP1737842B1
公开(公告)日：2010-08-18
申请号：EP05731650.7
申请日：2005-04-09
发明人： MUELLER, Stephan Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/14 , C07D471/10 , C07D513/04 , C07D453/04 , C07D401/04 , C07D451/04 , C07D471/04 , C07D495/04 , C07D487/08 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04 , C07D451/04 , C07D453/02 , C07D487/04 , C07D487/08
摘要： The invention relates to the CGRP antagonists of general formula (I), wherein A, X and R1 to R3 are defined as in claim 1. The invention also relates to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and to the hydrates of said salts, especially their physiologically acceptable salts with inorganic or organic acids, to drugs comprising said compounds, to their use and to a method for producing the same.
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