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1.发明授权
公开(公告)号：EP1597240B1
公开(公告)日：2008-09-10
申请号：EP04711303.0
申请日：2004-02-14
发明人： HIMMELSBACH, Frank , SOLCA, Flavio
IPC分类号： C07D239/94 , C07D405/12 , A61K31/55 , A61P35/00
CPC分类号： C07D413/12 , C07D413/14
摘要： The invention relates to bicyclic heterocycles of general formula (I), wherein Ra, Rb, Rc, Rd, Re, and X have the definitions indicated in claim 1, the tautomers, stereoisomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof containing inorganic or organic acids having valuable pharmaceutical properties, especially an inhibiting effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, especially cancer diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the production thereof.
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2.发明公开COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELLS, OR ANGIOGENESIS 有权复方制剂用于疾病的，增殖，迁移的治疗，骨髓瘤细胞的凋亡EMBRACE或血管生成
公开(公告)号：EP1622619A2
公开(公告)日：2006-02-08
申请号：EP04729366.7
申请日：2004-04-24
发明人： HILBERG, Frank , SOLCA, Flavio , STEFANIC, Martin Friedrich , BAUM, Anke , MUNZERT, Gerd , VAN MEEL, Jacobus, C.A.
IPC分类号： A61K31/496 , A61K31/517 , A61P35/00 , A61K31/404
CPC分类号： A61K31/496 , A61K31/404 , A61K31/517 , A61K31/553 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said deseases, coomprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
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3.发明公开BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, IHRE VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权BICYCLISCHE HETEROCYCLEN，DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL，IHRE VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1597240A1
公开(公告)日：2005-11-23
申请号：EP04711303.0
申请日：2004-02-14
发明人： HIMMELSBACH, Frank , SOLCA, Flavio
IPC分类号： C07D239/94 , C07D405/12 , A61K31/55 , A61P35/00
CPC分类号： C07D413/12 , C07D413/14
摘要： The invention relates to bicyclic heterocycles of general formula (I), wherein Ra, Rb, Rc, Rd, Re, and X have the definitions indicated in claim 1, the tautomers, stereoisomers, mixtures, and salts thereof, especially the physiologically acceptable salts thereof containing inorganic or organic acids having valuable pharmaceutical properties, especially an inhibiting effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, especially cancer diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract, and the production thereof.
摘要翻译： 本发明涉及通式（I）的双环杂环，其中Ra，Rb，Rc，Rd，Re和X具有权利要求1中所述的定义，其互变异构体，立体异构体，混合物和盐，特别是生理上可接受的盐 其含有具有有价值药物性质的无机或有机酸，特别是对由酪氨酸激酶介导的信号转导的抑制作用，其用于治疗疾病，特别是癌症疾病和良性前列腺增生（BPH），肺和呼吸道疾病的用途，以及 其生产。
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4.发明授权
公开(公告)号：EP1599478B1
公开(公告)日：2007-05-09
申请号：EP03816028.9
申请日：2003-02-26
发明人： HOFFMANN, Matthias , GRAUERT, Matthias , BRANDL, Trixi , BREITFELDER, Steffen , EICKMEIER, Christian , STEEGMAIER, Martin , SCHNAPP, Gisela , BAUM, Anke , QUANT, Jens, Jürgen , SOLCA, Flavio , COLBATZKY, Florian
IPC分类号： C07D475/04 , A61K31/4375 , A61K31/4985
CPC分类号： C07D475/00
摘要： The invention relates to novel dihydropteridinones of general formula (I), wherein rests L, R1-R5 have the significance indicated in claims and a specification, in the isomers thereof, in a method for producing and using said dihydropteridinones in the form of drugs.
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5.发明公开
公开(公告)号：EP1599478A1
公开(公告)日：2005-11-30
申请号：EP03816028.9
申请日：2003-02-26
发明人： HOFFMANN, Matthias , GRAUERT, Matthias , BRANDL, Trixi , BREITFELDER, Steffen , EICKMEIER, Christian , STEEGMAIER, Martin , SCHNAPP, Gisela , BAUM, Anke , QUANT, Jens, Jürgen , SOLCA, Flavio , COLBATZKY, Florian
IPC分类号： C07D475/04 , A61K31/4375 , A61K31/4985
CPC分类号： C07D475/00
摘要： The invention relates to novel dihydropteridinones of general formula (I), wherein rests L, R1-R5 have the significance indicated in claims and a specification, in the isomers thereof, in a method for producing and using said dihydropteridinones in the form of drugs.
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6.发明授权
公开(公告)号：EP1163227B1
公开(公告)日：2005-09-28
申请号：EP00909360.0
申请日：2000-03-14
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , BLECH, Stefan , JUNG, Birgit , METZ, Thomas , SOLCA, Flavio
IPC分类号： C07D239/94 , C07D215/54 , C07D401/12 , C07D413/12 , C07D405/12 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , A61K31/517 , C07D215/54 , C07D239/94 , C07D401/14 , C07D403/12 , C07D413/12
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7.发明公开CHINAZOLINE, DIESE VERBINDUNGEN ENTHALTENDE ALS TYROSINKINASE INHIBITOREN WIRKSAME ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开喹唑啉，含有它们作为酪氨酸激酶抑制剂的有效药物，它们的使用和工艺及其
公开(公告)号：EP1322645A2
公开(公告)日：2003-07-02
申请号：EP01978279.6
申请日：2001-08-18
IPC分类号： C07D413/12 , C07D239/94 , C07D405/12 , A61K31/517
CPC分类号： C07D405/12 , A61K31/505 , C07D239/94 , C07D413/12
摘要： The invention relates to quinazolines of general formula (I), in which Ra, Rb and n are defined as referred to in Claim No. 1, to their tautomers, their stereoisomers, and to their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable pharmacological properties, in particular, an inhibitive effect on the signal transduction imparted by tyrosine kinases. The invention also relates to the use of said quinazolines for treating diseases, especially tumor diseases, disorders of the lung and of the respiratory tract, and to the production thereof.
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8.发明公开4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN 有权4-（N-苯基氨基）-CHINAZOLINE /喹啉作为酪氨酸激酶抑制剂
公开(公告)号：EP1492536A1
公开(公告)日：2005-01-05
申请号：EP03745271.1
申请日：2003-03-25
发明人： HIMMELSBACH, Frank , JUNG, Birgit , SOLCA, Flavio
IPC分类号： A61K31/517 , C07D239/94 , C07D405/12 , C07D401/12 , C07D413/12 , C07D403/12 , C07D498/08 , C07D491/08 , A61P35/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D491/08
摘要： The invention relates to the bicyclic heterocycles of the general formula (I), wherein Ra, Rb, Rc, Rd and X are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on tyrosine kinase-mediated signal transduction. The invention also relates to the use of the bicyclic heterocycles in the treatment of diseases, especially cancer diseases and of benign prostate hyperplasia (BPH), of diseases of the lung and the respiratory system, and further to the production of the bicyclic heterocycles.
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9.发明授权4- ( N-PHENYLAMINO ) -CHINAZOLINE/CHINOLINE ALS TYROSINKINASEINHIBITOREN 有权4-（N-苯基氨基）-CHINAZOLINE / CHINOLINE ALS TYROSINKINASEINHIBITOREN
公开(公告)号：EP1492536B1
公开(公告)日：2012-05-09
申请号：EP03745271.1
申请日：2003-03-25
发明人： HIMMELSBACH, Frank , JUNG, Birgit , SOLCA, Flavio
IPC分类号： C07D239/94 , C07D405/12 , C07D405/14 , C07D401/12 , C07D413/12 , C07D403/12 , C07D498/08 , C07D491/08 , A61P35/00 , A61K31/517
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D491/08
摘要： The invention relates to the bicyclic heterocycles of the general formula (I), wherein Ra, Rb, Rc, Rd and X are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on tyrosine kinase-mediated signal transduction. The invention also relates to the use of the bicyclic heterocycles in the treatment of diseases, especially cancer diseases and of benign prostate hyperplasia (BPH), of diseases of the lung and the respiratory system, and further to the production of the bicyclic heterocycles.
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10.发明公开BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权BICYCLISCHE HETEROCYCLEN，DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL，DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1315718A1
公开(公告)日：2003-06-04
申请号：EP01976107.1
申请日：2001-08-18
IPC分类号： C07D405/12 , A61K31/517
CPC分类号： C07D405/12 , A61K31/505 , A61K31/517 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The invention relates to bicyclic heterocycles of general formula (I), in which Ra to Rd and X are defined as referred to in Claims Nos. 1 to 7, to their tautomers, their stereoisomers, and to their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable pharmacological properties, in particular, an inhibitive effect on the signal transduction imparted by tyrosine kinases. The invention also relates to the use of said bicyclic heterocycles for treating diseases, especially tumor diseases, disorders of the lung and of the respiratory tract, and to the production thereof.
摘要翻译： 本发明涉及通式（I）的双环杂环，其中R a至R d和X如权利要求1至7中所定义，涉及其互变异构体，其立体异构体及其盐，特别是其生理上相容的盐 与无机或有机酸或碱反应，其具有有价值的药理学性质，特别是对由酪氨酸激酶赋予的信号转导的抑制作用。 本发明还涉及所述双环杂环化合物用于治疗疾病，特别是肿瘤疾病，肺和呼吸道疾病及其生产的用途。
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