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    ANTIBODIES TO TIGIT
    1.
    发明公开
    ANTIBODIES TO TIGIT 审中-公开

    公开(公告)号：EP4249066A3

    公开(公告)日：2023-11-22

    申请号：EP23170440.4

    申请日：2015-12-22

    申请人： Bristol-Myers Squibb Company

    发明人： MAURER, Mark F. ,  CHEN, Tseng-Hui Timothy ,  DEVAUX, Brigitte ,  SRINIVASAN, Mohan ,  JULIEN, Susan H ,  SHEPPARD, Paul O. ,  ARDOUREL, Daniel F. ,  CHAKRABORTY, Indrani

    IPC分类号： C07K16/28

    摘要： The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

    ANTIBODIES TO TIGIT
    5.
    发明公开
    ANTIBODIES TO TIGIT 审中-公开

    公开(公告)号：EP4249066A2

    公开(公告)日：2023-09-27

    申请号：EP23170440.4

    申请日：2015-12-22

    申请人： Bristol-Myers Squibb Company

    发明人： MAURER, Mark F. ,  CHEN, Tseng-Hui Timothy ,  DEVAUX, Brigitte ,  SRINIVASAN, Mohan ,  JULIEN, Susan H ,  SHEPPARD, Paul O. ,  ARDOUREL, Daniel F. ,  CHAKRABORTY, Indrani

    IPC分类号： A61P35/00

    摘要： The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

    ANTIBODIES TO TIGIT
    6.
    发明公开
    ANTIBODIES TO TIGIT 审中-公开
    TIGIT的抗体

    公开(公告)号：EP3237448A1

    公开(公告)日：2017-11-01

    申请号：EP15823895.6

    申请日：2015-12-22

    申请人： Bristol-Myers Squibb Company

    发明人： MAURER, Mark F. ,  CHEN, Tseng-Hui Timothy ,  DEVAUX, Brigitte ,  SRINIVASAN, Mohan ,  JULIEN, Susan H. ,  SHEPPARD, Paul O. ,  ARDOUREL, Daniel F. ,  CHAKRABORTY, Indrani

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

    摘要： The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.

    摘要翻译： 本发明提供了结合人TIGIT（具有Ig和ITIM结构域的T细胞免疫受体）的抗体或其抗原结合片段，以及这些抗体或片段在治疗应用中的用途，例如用于治疗癌症或慢性 病毒感染。 这种治疗方法包括与其他免疫调节受体相互作用的抑制剂例如PD-1 / PD-L1相互作用的组合疗法。 本发明进一步提供编码抗体重链和/或轻链可变区的多核苷酸，包含编码抗体重链和/或轻链可变区的多核苷酸的表达载体，包含载体的细胞，以及制备抗体的方法或 片段通过从细胞中表达它们。