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公开(公告)号：EP3221363B1
公开(公告)日：2020-05-06
申请号：EP15816276.8
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61P35/00
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公开(公告)号：EP3484920A2
公开(公告)日：2019-05-22
申请号：EP17742626.9
申请日：2017-07-13
发明人： SCHEBYE, Xiao Min , SELBY, Mark J. , HAN, Michelle Minhua , BEE, Christine , DENG, Andy X. , CHUNTHARAPAI, Anan , DEVAUX, Brigitte , LI, Huiming , SHEPPARD, Paul O. , KORMAN, Alan J. , ARDOUREL, Daniel F. , DEYANOVA, Ekaterina , HUANG, Richard , CHEN, Guodong , KUHNE, Michelle , TRUONG, Hong-An
IPC分类号： C07K16/28
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公开(公告)号：EP3737700A1
公开(公告)日：2020-11-18
申请号：EP19702762.6
申请日：2019-01-11
发明人： SCHEBYE, Xiao Min , SELBY, Mark J. , HAN, Michelle Minhua , BEE, Christine , DENG, Andy X. , CHUNTHARAPAI, Anan , DEVAUX, Brigitte , LI, Huiming , SHEPPARD, Paul O. , KORMAN, Alan J. , ARDOUREL, Daniel F. , DEYANOVA, Ekaterina , HUANG, Richard , CHEN, Guodong , KUHNE, Michelle , TRUONG, Hong-An
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4.发明公开
公开(公告)号：EP3377532A2
公开(公告)日：2018-09-26
申请号：EP16805668.7
申请日：2016-11-17
发明人： WANG, Changyu , LONBERG, Nils , KORMAN, Alan, J. , SELBY, Mark, J. , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , HUANG, Haichun , WONG, Susan, Chien-Szu , LI, Huiming , BARNHART, Bryan, C. , YAMNIUK, Aaron, P. , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V. , RAJPAL, Arvind
CPC分类号： A61K39/39558 , A61K2039/507 , A61K2039/572 , A61P35/04 , C07K16/2818 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , G01N33/574 , G01N33/6863
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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5.发明公开ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF 审中-公开抗生素GEGEN GLUCOCORTICOIDINDUZIERTEN TUMORNEKROSEFAKTORREZEPTOR（GITR）UND VERWENDUNGEN DAVON
公开(公告)号：EP3151921A2
公开(公告)日：2017-04-12
申请号：EP15742414.4
申请日：2015-06-03
发明人： WANG, Changyu , LONBERG, Nils , KORMAN, Alan J. , SELBY, Mark J. , SRINIVASAN, Mohan , HENNING, Karla , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , HUANG, Haichun , WONG, Susan , LI, Huiming
CPC分类号： C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6863 , G01N33/6872 , G01N2333/70578 , G01N2333/7151
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
摘要翻译： 本文提供了结合糖皮质激素诱导型TNF受体（GITR）的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如治疗癌症。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。
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公开(公告)号：EP3221363A2
公开(公告)日：2017-09-27
申请号：EP15816276.8
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
摘要翻译： 本发明提供以高亲和力结合人分化簇73（CD73）并且抑制CD73的活性并且任选地介导抗体依赖性CD73内化的分离的单克隆抗体，特别是人抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和表达本发明抗体的方法。 还提供了包含本发明抗体的免疫缀合物，双特异性分子和药物组合物。 本发明还提供了使用本发明的抗体抑制表达CD73的肿瘤细胞生长的方法，包括治疗各种癌症的方法。
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公开(公告)号：EP3740506A1
公开(公告)日：2020-11-25
申请号：EP19706784.6
申请日：2019-01-15
发明人： SCHEBYE, Xiao Min , SELBY, Mark J. , HAN, Michelle Minhua , BEE, Christine , DENG, Andy X. , CHUNTHARAPAI, Anan , DEVAUX, Brigitte , LI, Huiming , SHEPPARD, Paul O. , KORMAN, Alan J. , ARDOUREL, Daniel F. , DEYANOVA, Ekaterina , HUANG, Richard , CHEN, Guodong , KUHNE, Michelle , TRUONG, Hong-An , PATAH, Poliana , JACKSON, Jeffrey R. , FLEMING, Ronald A.
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
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公开(公告)号：EP3725808A1
公开(公告)日：2020-10-21
申请号：EP20164125.5
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
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9.发明公开
公开(公告)号：EP3610924A1
公开(公告)日：2020-02-19
申请号：EP19184566.8
申请日：2015-06-03
发明人： WANG, Changyu , LONBERG, Nils , KORMAN, Alan J. , SELBY, Mark J. , SRINIVASAN, Mohan , HENNING, Karla , HAN, Michelle Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , HUANG, Haichun , WONG, Susan , LI, Huiming
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：EP3304079A1
公开(公告)日：2018-04-11
申请号：EP16731700.7
申请日：2016-06-02
发明人： WANG, Xi-tao , ADELAKUN, Olufemi, A. , LEWIN, Anne, C. , KORMAN, Alan, J. , SELBY, Mark, J. , WANG, Changyu , HUANG, Haichun , HENNING, Karla, A. , LONBERG, Nils , SRINIVASAN, Mohan , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , WONG, Susan, Chien-Szu , LI, Huiming
IPC分类号： G01N33/566 , C07K16/28
摘要： Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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