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    Reagent handling systems and reagent packs
    4.
    发明公开
    Reagent handling systems and reagent packs 失效
    HandhabungssystemfürReagenzien，und Reagenzienpackungen

    公开(公告)号：EP0757253A1

    公开(公告)日：1997-02-05

    申请号：EP96305015.8

    申请日：1996-07-05

    申请人： Ciba Corning Diagnostics Corp.

    发明人： Carey, Glen A. ,  Weber, David P.

    IPC分类号： G01N35/00

    CPC分类号： G01N35/1002 ,  B01F13/0016 ,  B01F15/00824 ,  B01F2215/0037 ,  G01N35/00 ,  G01N2035/00514 ,  G01N2035/00524 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/2575

    摘要： A reagent pack for keeping fluids with or without suspensions mixed or suspended upon rocking. The reagent pack has at leat one chamber (120) divided into separate sub-chambers (126a,126b) with a throat region (124) between them defined by baffles (122a,122b) for agitation of suspended reagent during rocking of the reagent pack. A continuous lid sealable to the pack has membrane sealed apertures in the lid for allowing access to the underlying chambers (120) and sub-chambers (126a,126b) by withdrawal needles. A tray is configured to hold multiple side-by-side reagent packs on respective slides that slide in and out for insertion and withdrawal of the packs. During operation, the tray and associated packs are rocked such as by being periodically inclined with respect to horizontal, providing reagent agitation. Optical annunciators proximate the tray indicate respective reagent pack activity under control of a computer which stores information on the contents of each pack tray location and correlates it to scheduled reagent use in a medical testing system. The tray is provided with a thermally conductive hinge. The tray with packs is located in an enclosure.

    摘要翻译： 用于在摇摆时混合或悬浮悬浮液的混合物用于保持液体的试剂盒。 试剂盒在一个室（120）中分离成分开的分室（126a，126b），其中在它们由挡板（122a，122b）限定的喉部区域（124）之间，用于在试剂组摇动期间搅拌悬浮试剂 。 可密封到包装上的连续盖在盖中具有膜密封的孔，用于允许通过取出针进入下面的室（120）和子室（126a，126b）。 托盘被配置为将多个并排试剂包保持在滑入和滑出的相应滑块上以插入和取出包装。 在操作期间，托盘和相关的包装件被摇摆，例如通过周期性地相对于水平倾斜，提供试剂搅动。 靠近托盘的光学信号器在计算机的控制下指示相应的试剂盒活动，该计算机存储关于每个包装托盘位置的内容的信息，并将其与医疗测试系统中的预定试剂使用相关联。 托盘设有导热铰链。 带有包装的托盘位于外壳中。

    Specimen testing apparatus
    5.
    发明公开
    Specimen testing apparatus 失效
    标本检测仪器

    公开(公告)号：EP0753735A2

    公开(公告)日：1997-01-15

    申请号：EP96305122.2

    申请日：1996-07-11

    申请人： Ciba Corning Diagnostics Corp.

    发明人： Malek, Michael L. ,  Coghlan, Gregory A. ,  Carey, Glen A.

    IPC分类号： G01N21/76 ,  G01N35/02 ,  G01J1/04

    CPC分类号： G01N21/76 ,  G01N21/13 ,  G01N2035/0448 ,  Y10T436/114165

    摘要： A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the segments. The luminometer further includes one or two detector assemblies (110,112) coupled to the housing and positioned to view and detect light emitted by cuvettes as they pass along the guide path between segments. A cuvette is advanced around the housing via the rotor and rotor segments and when the cuvette reaches a predetermined position on the housing, a reagent, such as a base, is added to the cuvette to initiate a chemiluminescent reaction within the cuvette and provide an emission of light energy in a predetermined spectral range. The luminometer has a waste aspiration probe to remove the contents of the cuvette after it passes the detector. A cuvette elevator moves a sample containing cuvette into the guide path between segments and an exit chute removes cuvettes after their contents have been aspirated. The luminometer permits continuous uninterrupted sample testing when coupled to an incubation chamber in which the cuvettes receive samples and test specific reagents before they are moved into the luminometer by the elevator.
    The luminometer has a temperature detection and control circuit coupled to the detector (PMT) (110) with thermal insulating sleeve (126). A TED (132) is coupled to the PMT thermal sleeve. The PMT comprises a lens cap (128) and a seal.

    摘要翻译： 用于确定样本组成的发光计包括用于包含在不透光外壳内的比色皿的样本的环形导向路径。 转子将间隔开的部分移动通过引导路径，反应杯定位在部分之间。 发光计还包括一个或两个检测器组件（110,112），所述检测器组件耦合到壳体并定位成当它们沿着区段之间的引导路径通过时观察和检测由比色管发射的光。 试管通过转子和转子区段在壳体周围推进，并且当试管到达壳体上的预定位置时，向试管添加诸如基座的试剂以在试管内引发化学发光反应并提供发射 的光能在预定的光谱范围内。 光度计有一个废物吸取探针，以在通过检测器后移除比色杯的内容物。 比色杯升降器将含有比色皿的样品移动到区段之间的引导路径中，并且出口溜槽在其内容物已经被抽吸之后移除比色皿。 该光度计在连接到孵育室时允许连续不间断的样品测试，在该孵育室中比色杯接收样品并且在特定试剂被电梯移入发光计之前测试特定试剂。 该发光计具有与检测器（PMT）（110）耦合的具有热绝缘套筒（126）的温度检测和控制电路。 TED（132）耦合到PMT热套筒。 PMT包括镜头盖（128）和密封件。

    Apparatus for use in automated analyzer
    6.
    发明公开
    Apparatus for use in automated analyzer 失效
    在自动分析装置中使用的设备

    公开(公告)号：EP0984284A2

    公开(公告)日：2000-03-08

    申请号：EP99203974.3

    申请日：1992-02-21

    申请人： Ciba Corning Diagnostics Corp.

    发明人： Carey, Glen A. ,  Lewis, Scott C. ,  Mann, Raymond A. ,  Whitesel, Mary Beth ,  Polaniec, James P. ,  Woyansky, George J. ,  Pabst, Stefan R. ,  Klingshirn, Frank C.

    IPC分类号： G01N35/02 ,  G01N21/76 ,  B01L3/00

    CPC分类号： B01L3/508 ,  B01L2300/0854 ,  G01N21/76 ,  G01N35/0098 ,  G01N35/021 ,  G01N35/025 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2035/00386 ,  G01N2035/00396 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0465 ,  G01N2035/0484 ,  G01N2035/0486 ,  G01N2035/1025 ,  Y10S215/01 ,  Y10S215/03 ,  Y10S215/08 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Inter alia , an apparatus for selectively dispensing reagent into first and second vertical reagent dispense axes, for use in an automated analyzer to assay a test sample, the said analyzer having an event conveyor for conveying a plurality of cuvettes along an event path which includes a vertical sample dispense axis, the said first vertical reagent dispense axis which is spaced from and downstream of the said sample dispense axis and the said second vertical reagent dispense axis which is spaced from and downstream of the said first reagent axis, the said apparatus being characterised in that it comprises:

    (a) a reagent transport and selection means for supporting a plurality of first reagent containers which contain labeled reagent and a plurality of second reagent containers which contain solid phase reagent, and for selectively positioning any one of the said first reagent containers at one of a first vertical reagent aspirating axis and a second vertical reagent aspirating axis, and for selectively positioning any one of the said second reagent containers at one of a third vertical reagent aspirating axis and a fourth vertical reagent aspirating axis;
    (b) a first reagent probe transport means for supporting a first reagent aspirating and dispense probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said first reagent dispense axis and either of the said first and third reagent dispense axes;
    (c) a second reagent probe transport means for supporting a second reagent aspirating and dispensing probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said second reagent dispense axis and either of the said second and fourth dispense axes;
    and
    (d) control means including a central processing unit operatively connected to the said reagent transport and selection means, the said first reagent probe transport means and the said second reagent transport means for selectively positioning a predetermined first reagent container at either of the said first and second reagent aspirating axes and a predetermined second reagent container at either of the said third and fourth reagent aspirating axes, for selectively positioning the said first reagent probe for aspirating reagent from a selected first reagent container at the said first reagent aspirating axis or a selected second reagent container at the said third reagent aspirating axis, or from both of the said selected first and second selected reagent containers and for dispensing aspirated reagent into a cuvette at the said first reagent dispense axis, and, for selectively positioning the said second reagent probe for aspirating reagent from a selected first reagent container at the said second reagent aspirating axis or a selected second reagent container at the said fourth reagent aspirating axis, or from both of the said selected first and second reagent containers and for dispensing aspirated reagent into a cuvette at the said second reagent dispense axis is disclosed.

    Incubation chamber in automated immunoassay analyser
    7.
    发明公开
    Incubation chamber in automated immunoassay analyser 失效
    Inkubationskammer einer automatischen immunologischen Analysevorrichtung

    公开(公告)号：EP0712000A2

    公开(公告)日：1996-05-15

    申请号：EP95306882.2

    申请日：1995-09-29

    申请人： Ciba Corning Diagnostics Corp.

    发明人： Carey, Glen A. ,  Malek, Michael L.

    IPC分类号： G01N35/02 ,  G01N33/543

    CPC分类号： B01L3/50853 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/025 ,  G01N2035/0455 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    摘要： Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument (10). The apparatus includes a cuvette ring (32) movably coupled to a magnet ring (30). In one embodiment, the magnet ring (30) and cuvette ring (32) are provided having circular shapes. A temperature controlled housing (28) is disposed about the cuvette and magnet rings to provide a rotary incubation and particle separation chamber (12). The cuvette ring (32) holds a plurality of cuvettes each of which may have a different assay disposed therein. The cuvette ring (32) advances the cuvettes around the circumference of the incubation chamber. A plurality of discrete processing centers for aspiration and dispensing fluid samples, reagents and wash fluids are disposed at predetermined positions about the incubation chamber (12). The cuvette ring (32) moves cuvettes in both clockwise and counter clockwise directions around the incubation chamber (12) to position particular cuvettes at particular ones of the plurality of discrete processing centers to thus accomodate different protocols of each of the assays. By controlling the manner in which the cuvette ring (32) moves within the incubation chamber (12), a plurality of different protocol assays each of which require different incubation times, can be simultaneously processed in the analyzer instrument.

    摘要翻译： 用于在自动免疫分析仪器（10）内运输和处理多种方案测定的方法和装置。 该装置包括可移动地联接到磁环（30）的比色皿环（32）。 在一个实施例中，提供具有圆形形状的磁环（30）和比色杯环（32）。 温度控制的壳体（28）围绕比色皿和磁体环设置，以提供旋转孵育和颗粒分离室（12）。 试管环（32）容纳多个比色皿，每个比色杯可以在其中设置不同的测定。 比色皿环（32）将孵育室周围的比色杯推进。 多个用于抽吸和分配液体样品，试剂和洗涤液的离散处理中心设置在围绕孵育室（12）的预定位置处。 试管环（32）围绕孵育室（12）沿顺时针和逆时针方向移动试管，以将特定的比色杯定位在多个离散加工中心中的特定的比色皿上，从而适应每个测定的不同方案。 通过控制比色皿环（32）在孵育室（12）内移动的方式，可以在分析仪器中同时处理多个不同的方案测定，每种方法都需要不同的孵育时间。

    Apparatus for use in automated analyzer
    8.
    发明公开
    Apparatus for use in automated analyzer 失效
    在自动分析装置中使用的设备

    公开(公告)号：EP0984284A3

    公开(公告)日：2000-05-31

    申请号：EP99203974.3

    申请日：1992-02-21

    申请人： Ciba Corning Diagnostics Corp.

    发明人： Carey, Glen A. ,  Lewis, Scott C. ,  Mann, Raymond A. ,  Whitesel, Mary Beth ,  Polaniec, James P. ,  Woyansky, George J. ,  Pabst, Stefan R. ,  Klingshirn, Frank C.

    IPC分类号： G01N35/02 ,  G01N21/76 ,  B01L3/00

    CPC分类号： B01L3/508 ,  B01L2300/0854 ,  G01N21/76 ,  G01N35/0098 ,  G01N35/021 ,  G01N35/025 ,  G01N35/1002 ,  G01N35/1065 ,  G01N2035/00386 ,  G01N2035/00396 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0465 ,  G01N2035/0484 ,  G01N2035/0486 ,  G01N2035/1025 ,  Y10S215/01 ,  Y10S215/03 ,  Y10S215/08 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Inter alia, an apparatus for selectively dispensing reagent into first and second vertical reagent dispense axes, for use in an automated analyzer to assay a test sample, the said analyzer having an event conveyor for conveying a plurality of cuvettes along an event path which includes a vertical sample dispense axis, the said first vertical reagent dispense axis which is spaced from and downstream of the said sample dispense axis and the said second vertical reagent dispense axis which is spaced from and downstream of the said first reagent axis, the said apparatus being characterised in that it comprises: (a) a reagent transport and selection means for supporting a plurality of first reagent containers which contain labeled reagent and a plurality of second reagent containers which contain solid phase reagent, and for selectively positioning any one of the said first reagent containers at one of a first vertical reagent aspirating axis and a second vertical reagent aspirating axis, and for selectively positioning any one of the said second reagent containers at one of a third vertical reagent aspirating axis and a fourth vertical reagent aspirating axis; (b) a first reagent probe transport means for supporting a first reagent aspirating and dispense probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said first reagent dispense axis and either of the said first and third reagent dispense axes; (c) a second reagent probe transport means for supporting a second reagent aspirating and dispensing probe for selective vertical movement between an upper position and a lower aspirating and dispense position and for selective horizontal movement between the said second reagent dispense axis and either of the said second and fourth dispense axes; and (d) control means including a central processing unit operatively connected to the said reagent transport and selection means, the said first reagent probe transport means and the said second reagent transport means for selectively positioning a predetermined first reagent container at either of the said first and second reagent aspirating axes and a predetermined second reagent container at either of the said third and fourth reagent aspirating axes, for selectively positioning the said first reagent probe for aspirating reagent from a selected first reagent container at the said first reagent aspirating axis or a selected second reagent container at the said third reagent aspirating axis, or from both of the said selected first and second selected reagent containers and for dispensing aspirated reagent into a cuvette at the said first reagent dispense axis, and, for selectively positioning the said second reagent probe for aspirating reagent from a selected first reagent container at the said second reagent aspirating axis or a selected second reagent container at the said fourth reagent aspirating axis, or from both of the said selected first and second reagent containers and for dispensing aspirated reagent into a cuvette at the said second reagent dispense axis is disclosed.