公开(公告)号：EP4435410A1

公开(公告)日：2024-09-25

申请号：EP23163380.1

申请日：2023-03-22

申请人： Siemens Healthineers AG

发明人： Huang, Yiwei ,  Paulicka, Peter

IPC分类号： G01N21/76 ,  G01N21/25

CPC分类号： G01N21/76 ,  G01N21/253 ,  G01N2201/041520130101

摘要： The present invention relates to a multiplexing detection device comprising an optical filter, a high sensitivity optical detector, a collimating lens, a terminal mirror, a cuvette holder designed to hold a cuvette, wherein said cuvette is a reaction vessel for a non-excited chemiluminescence reaction emitting photons which are collected, transmitted through the optical filter and detected by the high sensitivity optical detector; and a synchronization module, which is designed to synchronize the operation of the optical detector and initiation of the chemiluminescence reaction. Also provided is a corresponding method for detecting a molecular interaction between at least one target molecule and an interactor molecule, the use of the device for a multiplex detection of a molecular interaction and a system for multiplex detection.

公开(公告)号：EP3700420B1

公开(公告)日：2024-09-25

申请号：EP18871316.8

申请日：2018-10-26

IPC分类号： A61B5/083 ,  A61B5/093 ,  A61B5/097 ,  G01N21/01 ,  G01N33/497 ,  B01L3/00 ,  G01N1/28 ,  G01N21/64 ,  G01N21/03 ,  G01N21/69 ,  G01N21/76 ,  A61B5/00 ,  G01N21/51 ,  G01N21/65 ,  A61B5/145 ,  A61B5/1468 ,  G01N33/49 ,  H04M1/72409

CPC分类号： A61B5/6893 ,  A61B5/0071 ,  A61B5/097 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/1468 ,  G01N33/49 ,  G01N21/0303 ,  G01N2021/038920130101 ,  G01N2021/03620130101 ,  G01N2021/65120130101 ,  G01N2021/648220130101 ,  G01N21/69 ,  G01N21/76 ,  G01N21/51 ,  G01N21/645 ,  G01N1/2813 ,  B01L3/5055 ,  H04M1/72409

公开(公告)号：EP4025911B8

公开(公告)日：2024-08-28

申请号：EP20797166.4

申请日：2020-09-04

IPC分类号： G01N33/543 ,  G01N21/00

CPC分类号： G01N33/5432 ,  G01N21/554 ,  G01N21/76 ,  G01N21/64

公开(公告)号：EP4244604B1

公开(公告)日：2024-07-10

申请号：EP21730653.9

申请日：2021-05-12

IPC分类号： G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N33/543

CPC分类号： G01N21/69 ,  G01N21/76 ,  G01N2201/022120130101 ,  B01L3/502761 ,  B01L2300/064520130101 ,  B01L3/502715 ,  B01L2300/06920130101 ,  B01L2300/16120130101 ,  B01L2400/040620130101 ,  G01N33/5438

公开(公告)号：EP3629009B1

公开(公告)日：2024-07-03

申请号：EP19197840.2

申请日：2019-09-17

IPC分类号： G01N21/64 ,  G01N21/76

CPC分类号： G01N21/6456 ,  G01N21/76 ,  G01N2021/647820130101

公开(公告)号：EP4025911B1

公开(公告)日：2024-06-26

申请号：EP20797166.4

申请日：2020-09-04

IPC分类号： G01N33/543 ,  G01N21/00

CPC分类号： G01N33/5432 ,  G01N21/554 ,  G01N21/76 ,  G01N21/64

公开(公告)号：EP3814757B1

公开(公告)日：2024-06-12

申请号：EP19827329.4

申请日：2019-06-27

IPC分类号： G01N33/18 ,  B08B3/14 ,  B08B9/08 ,  G01N21/45 ,  G01N21/76 ,  G01N21/77 ,  G01N21/78

CPC分类号： G01N33/1826 ,  B08B3/14 ,  B08B9/08 ,  G01N21/76 ,  G01N2021/777920130101 ,  G01N21/78 ,  G01N33/184

公开(公告)号：EP3123151B1

公开(公告)日：2018-11-28

申请号：EP15767906.9

申请日：2015-03-24

申请人： Siemens Healthcare Diagnostics Inc.

发明人： LI, Jay J. ,  LEDDEN, David J. ,  COWDEN, Eric Scott ,  LU, Donglai

IPC分类号： G01N21/76 ,  G01N33/542 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/5308 ,  G01N21/76 ,  G01N33/542 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/582 ,  G01N2800/32 ,  G01N2800/325

摘要： A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in accordance with the presently disclosed and claimed inventive concept(s). For example, each of the first, second, and third antibodies/binding fragments may be a polyclonal antibody/binding fragment or a monoclonal antibody/binding fragment.

公开(公告)号：EP2972354B1

公开(公告)日：2018-10-03

申请号：EP14779477.0

申请日：2014-03-11

申请人： Geneweave Biosciences Inc.

发明人： REY, Diego Ariel ,  ROY, Shaunak ,  TEIXEIRA, Leonardo M. ,  GRISWOLD, Ryan C. ,  MATTHEWS, Damian S. ,  OLSON, Kenneth G. ,  RICHARDSON, Bruce J. ,  STELLMACHER, Rick V. ,  YEE, Victor H.

IPC分类号： G01N33/53 ,  G01N33/542 ,  C12P19/34

CPC分类号： C12Q1/6897 ,  B01L3/502 ,  B01L3/50825 ,  B01L3/52 ,  B01L3/523 ,  B01L3/54 ,  B01L3/545 ,  B01L7/00 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2400/0478 ,  B01L2400/06 ,  B01L2400/0683 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/06 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/66 ,  G01J1/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/13 ,  G01N21/76 ,  G01N21/763 ,  G01N2035/00346 ,  G01N2035/0405 ,  G01N2333/195

摘要： Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

公开(公告)号：EP3324175A1

公开(公告)日：2018-05-23

申请号：EP17175746.1

申请日：2013-04-23

申请人： Siemens Healthcare Diagnostics Inc.

发明人： JASPERSE, Jeffrey R. ,  DESMARAIS, Normand P.

IPC分类号： G01N21/76

CPC分类号： G01N21/76 ,  G01N21/645 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6476 ,  G01N2201/0245 ,  G01N2201/0634 ,  G01N2201/0636 ,  G01N2201/0666

摘要： Disclosed is a sample analyzer, comprising: an illuminator; a support positioned to support a sample vessel containing an assay sample proximate the illuminator, such that the illuminator causes luminescence of the assay sample; a detector positioned along an optical axis extending from the illuminator, through the assay sample, to the detector, so as to detect luminescence of the assay sample; a shuttle disposed between the illuminator and the assay sample; and a reflector disposed on the shuttle. The apparatus is configured with an illumination mode and a measurement mode, wherein during the illumination mode the shuttle positions the reflector off the optical axis, and the illuminator is operated to illuminate the assay sample, wherein during the measurement mode the shuttle positions the reflector onto the optical axis such that luminescence from the assay sample is reflected off the reflector back through the assay sample towards the detector along the optical axis. Further disclosed is a method of analyzing an assay sample, using the sample analyzer.