LIQUID DISTRIBUTION AND METERING
    1.
    发明授权

    公开(公告)号:EP2552589B1

    公开(公告)日:2018-12-26

    申请号:EP11720608.6

    申请日:2011-03-26

    申请人: Biosurfit, S.A.

    IPC分类号: B01L3/00

    摘要: Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12). A corresponding system for operating the 15 device and method for processing of a sample using the device is also disclosed.

    Storage and supply of vessel holders

    公开(公告)号:EP2887071B1

    公开(公告)日:2018-12-05

    申请号:EP13198403.1

    申请日:2013-12-19

    IPC分类号: G01N35/04 G01N33/00

    摘要: The invention relates to an automated system for processing vessels containing biological samples, the system including vessel holders, a transport medium for transporting the vessel holders between the components of the system, a work cell for processing, a storage module for empty vessel holders, wherein the storage module is connected to the transport medium, a robotic manipulator for engaging and/or disengaging the vessels with empty vessel holders, an empty vessel holder transfer unit for introducing empty vessel holders into or retrieving them from the storage module, and an empty vessel holder detection unit, including an empty vessel holder detector for discriminating between filled and empty vessel holders as well as a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the storage module by the empty vessel holder transfer unit. The invention further provides a corresponding method.

    BLOOD COAGULATION ANALYZER AND METHOD OF ANALYZING BLOOD COAGULATION

    公开(公告)号:EP2259069B1

    公开(公告)日:2018-09-12

    申请号:EP09726460.0

    申请日:2009-03-26

    摘要: A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration. The blood coagulation analyzer (1) includes a detecting section for detecting a transmitted light intensity from a first measurement sample prepared from a blood and a PT measurement reagent; a dFbg acquisition means for acquiring, based on the light detected from the first measurement sample, a dFbg value reflecting a Fbg in the blood; a determination means for determining whether the dfbg value is within a predetermined range or not; a detecting section for detecting a transmitted light intensity from a socend measurement sample prepared from the blood and a Fbg measurement reagent when the dFbg value is outside the predetermined range; and a Fbg acquisition means for acquiring, based on a transmitted light intensity from the second measurement sample detected, a Fbg concentration in the blood sample.

    METHODS AND SYSTEMS PROVIDING REAGENT MIXING

    公开(公告)号:EP2556360A4

    公开(公告)日:2017-12-13

    申请号:EP11766600

    申请日:2011-04-05

    IPC分类号: G01N1/00 B01F11/00 G01N35/10

    摘要: Disclosed are methods and systems adapted to provide mixing of a liquid reagent in an automated clinical analyzer. The methods include aspirating an air separator (e.g., an air slug) into the interior of a probe. A relatively small volume of reagent liquid is also aspirated into the probe adjacent to the air separator; the volume of liquid reagent being entirely contained within the probe. The volume of liquid reagent may be repeatedly aspirated and dispensed at a relatively high frequency to accomplish reagent mixing in the reagent container. Improved sample and reagent mixing may be promoted using a similar method. Systems carrying out the methods are provided, as are other aspects.