摘要:
Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12). A corresponding system for operating the 15 device and method for processing of a sample using the device is also disclosed.
摘要:
Analyzing the pressure profile generated during a predetermined period of time prior to the end of an aspiration or dispensing process and comparing a pressure reading to predetermined values to determine if the aspiration or dispensing pipette was free of clogs.
摘要:
The invention relates to an automated system for processing vessels containing biological samples, the system including vessel holders, a transport medium for transporting the vessel holders between the components of the system, a work cell for processing, a storage module for empty vessel holders, wherein the storage module is connected to the transport medium, a robotic manipulator for engaging and/or disengaging the vessels with empty vessel holders, an empty vessel holder transfer unit for introducing empty vessel holders into or retrieving them from the storage module, and an empty vessel holder detection unit, including an empty vessel holder detector for discriminating between filled and empty vessel holders as well as a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the storage module by the empty vessel holder transfer unit. The invention further provides a corresponding method.
摘要:
Fluid storage containers and analysis cartridges for use in assay processes are presented. In addition, systems comprising such storage containers and analysis cartridges and methods of using such containers and cartridges are presented as well. In specific embodiments, fluid storage containers are configured to be coupled to analysis cartridges in a first stage and a second stage.
摘要:
A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration. The blood coagulation analyzer (1) includes a detecting section for detecting a transmitted light intensity from a first measurement sample prepared from a blood and a PT measurement reagent; a dFbg acquisition means for acquiring, based on the light detected from the first measurement sample, a dFbg value reflecting a Fbg in the blood; a determination means for determining whether the dfbg value is within a predetermined range or not; a detecting section for detecting a transmitted light intensity from a socend measurement sample prepared from the blood and a Fbg measurement reagent when the dFbg value is outside the predetermined range; and a Fbg acquisition means for acquiring, based on a transmitted light intensity from the second measurement sample detected, a Fbg concentration in the blood sample.
摘要:
Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.
摘要:
An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.
摘要:
Disclosed are methods and systems adapted to provide mixing of a liquid reagent in an automated clinical analyzer. The methods include aspirating an air separator (e.g., an air slug) into the interior of a probe. A relatively small volume of reagent liquid is also aspirated into the probe adjacent to the air separator; the volume of liquid reagent being entirely contained within the probe. The volume of liquid reagent may be repeatedly aspirated and dispensed at a relatively high frequency to accomplish reagent mixing in the reagent container. Improved sample and reagent mixing may be promoted using a similar method. Systems carrying out the methods are provided, as are other aspects.